Developing an Information System for Sustainable Natural Resource Management in Alborz Watershed, Northern Iran

This article explores the potentials of systems analysis and design of information system for sustainable natural resource management. Soft and hard system analyses were performed to better understand the information needs and design of an information system for improving decision making for achieving sustainable natural resource management. In order to analyze the complex and soft systems situations for developing an effective information system, which meets related actors’ changing needs, a conceptual model inspired by soft systems methodology (SSM) was developed. This model is based on information derived from twelve farmers who were purposely selected to represent diverse conditions and 23 agricultural extension experts across the Alborz Watershed in Mazandaran Province, located in northern Iran. Since a conceptual model resulting from SSM is not in itself sufficient as the basis for the implementation of information systems, a hard system methodology was used to structure the data handling by using unified modeling language. This research has shown the promising potentiality of using soft system analysis methodology as a preliminary step to the actual design of an information system in the natural resource management situation in the watershed system level when combined with hard system analysis methods.     

CD4<Superscript>+</Superscript> T cell-mediated immunity against prion proteins

The prion protein (PrP(C)) is essential for susceptibility to transmissible spongiform encephalopathies. A specific conformer of this protein (PrP(Sc)) is, according to the 'protein only' hypothesis, the principal or only component of the infectious agent, designated prion. Transmission of prions between species is often inefficient, resulting in low attack rates and/or prolonged incubation times and is ascribed to a 'species barrier' caused by differences in the amino acid sequence of PrP between recipient and donor. In this report, we demonstrate that these differences in amino acid sequence result in presentation of distinct peptides on major histocompatibility complex class II molecules. These peptides result in activation of specific CD4+ T cells which leads to the induction of an effective immune response against foreign PrP as demonstrated by antibody production. Therefore, CD4+ T cells represent a crucial component of the immune system to distinguish between foreign and self PrP.     

Biogenic amino acid methionine-based corrosion inhibitors of mild steel in acidic media

N,N-Diallyl methionine ethyl ester hydrochloride 5 underwent alternating copolymerization with SO_2 via the Butler cyclopolymerization protocol in dimethyl sulfoxide(DMSO) to give water-soluble cycloterpolymer 6 with a ～1:1 molar ratio of sulfide and sulfoxide groups as a result of oxygen transfer from DMSO. Half of the sulfide groups in 6, upon oxidation with H_2O_2, afforded polymer sulfoxide 7 and polymer sulfone 8. The solution properties of these polymers were determined via a viscometric technique. The thermal stability of these polymers was determined by thermogravimetric analysis. The inhibition efficiency obtained from gravimetric mass loss, potentiodynamic polarization, and electrochemical impedance spectroscopy techniques agreed well with each other. The corrosion efficiencies increase with increasing concentration of the polymers. At a polymer concentration of 175 mM, the maximum inhibition efficiency of copolymer compounds 6–8 was determined to be 92%, 97%, and 95%, respectively. The synthesized polymer compounds acted as mixed-type inhibitors. Polymer compound 7 adsorbed onto the metal surface via chemisorption and physisorption and obeyed Langmuir, Temkin, and Freundlich adsorption isotherms. Analyses by X-ray photoelectron spectroscopy and scanning electron microscopy–energy-dispersive X-ray spectroscopy indicated that the adsorbed polymers formed a thin film on the metal surface and prevented further corrosive attack.     

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA replication stress, which leads to activation of the DNA damage checkpoint and thereby to apoptosis or cell cycle arrest, whereas a second barrier is mediated by oncogene-induced senescence. The relationship between these two barriers, if any, has not been elucidated. Here we show that oncogene-induced senescence is associated with signs of DNA replication stress, including prematurely terminated DNA replication forks and DNA double-strand breaks. Inhibiting the DNA double-strand break response kinase ataxia telangiectasia mutated (ATM) suppressed the induction of senescence and in a mouse model led to increased tumour size and invasiveness. Analysis of human precancerous lesions further indicated that DNA damage and senescence markers cosegregate closely. Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression.     

Feasibility of a novel beamforming algorithm via retrieving spatial harmonics

This paper introduces an algorithm for beamforming systems by the aid of multidimensional harmonic retrieval(MHR).This algorithm resolves problems,removes limitations of sampling and provides a more robust beamformer.A new sample space is created that can be used for estimating weights of a new beamforming called spatial-harmonics retrieval beamformer(SHRB).Simulation results show that SHRB has a better performance,accuracy,and applicability and more powerful eigenvalues than conventional beamformers.A simple mathematical proof is provided.By changing the number of harmonics,as a degree of freedom that is missing in conventional beamformers,SHRB can achieve more optimal outputs without increasing the number of spatial or temporal samples.We will demonstrate that SHRB offers an improvement of 4 dB in signal to noise ratio(SNR) in bit error rate(BER) of 10~(-4) over conventional beamformers.In the case of direction of arrival(DOA) estimation,SHRB can estimate the DOA of the desired signal with an SNR of-25 dB,when conventional methods cannot have acceptable response.     

PLATFORM SELECTION FOR COMPLEX SYSTEMS:BUILDING AUTOMATION SYSTEMS

Automation systems for buildings interconnect components and technologies from the information technology industry and the telecommunications industry.In these industries,existing platforms and new platforms（that are designed to make building automation systems work） compete for market acceptance and consequently several platform battles among suppliers for building automation networking are being waged.It is unclear what the outcome of these battles will be and also which factors are important in achieving platform dominance.Taking the fuzziness of decision makers＇ judgments into account,a fuzzy multi-criteria decision-making methodology called the Fuzzy Analytic Hierarchy Process is applied to investigate the importance of such factors in platform battles for building automation networking.We present the relative importance of the factors for three types of platforms（subsystem platforms,system platforms,and evolved subsystem platforms）.The results provide a first indication that the set of important factors differs per type of platform.For example,when focusing on other stakeholders,for subsystem platforms,the previous installed base is of importance;for system platforms,the diversity of the network of stakeholders is essential;and for evolved subsystem platforms,the judiciary is an important factor.     

Magnetohydrodynamic flow over a moving plate in a parallel stream with an induced magnetic field

A viscous boundary layer flow of an electrically-conducting fluid over a moving flat plate in a parallel stream with a constant magnetic field applied outside the boundary layer parallel to the plate was investigated. The governing system of partial differential equations was transformed to ordinary differential equations using a similarity transformation. The similarity equations were then solved numerically using a finite-difference scheme known as the Keller-box method. Numerical results of the skin friction coefficient, velocity profiles, and the induced magnetic field profiles were obtained for some values of the moving parameter, magnetic parameter, and reciprocal magnetic Prandtl number. The results indicate that dual solutions exist when the plate and the fluid move in the opposite directions up to a critical value of the moving parameter, whose value depends on the value of the magnetic parameter.     

Automatic modulation classification using modulation fingerprint extraction

An automatic method for classifying frequency shift keying (FSK), minimum shift keying (MSK), phase shift keying (PSK), quadrature amplitude modulation (QAM), a...     

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10(-4) for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)). SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10(-4)), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D.     

CEACAM1 regulates insulin clearance in liver

We hypothesized that insulin stimulates phosphorylation of CEACAM1 which in turn leads to upregulation of receptor-mediated insulin endocytosis and degradation in the hepatocyte. We have generated transgenic mice over-expressing in liver a dominant-negative, phosphorylation-defective S503A-CEACAM1 mutant. Supporting our hypothesis, we found that S503A-CEACAM1 transgenic mice developed hyperinsulinemia resulting from impaired insulin clearance. The hyperinsulinemia caused secondary insulin resistance with impaired glucose tolerance and random, but not fasting, hyperglycemia. Transgenic mice developed visceral adiposity with increased amounts of plasma free fatty acids and plasma and hepatic triglycerides. These findings suggest a mechanism through which insulin signaling regulates insulin sensitivity by modulating hepatic insulin clearance.