New testing methodology for the quantification of rock crushability: Compressive crushing value (CCV)

Crushing is a size reduction process that plays a key role in both mineral processing and crushing-screening plant design. Investigations on rock crushability have become an important issue in mining operations and the manufacture of industrial crusher equipment. The main objective of this research is to quantify the crushability of hard rocks based on their mineralogical and mechanical properties. For this purpose, the mineralogical, physical, and mechanical properties of various hard rocks were determined. A new compressive crushing value (CCV) testing methodology was proposed. The results obtained from CCV tests were compared with those from mineralogical inspections, rock strength as well as mechanical aggregate tests. Strong correlations were found between CCV and several rock and aggregate properties such as uniaxial compressive strength (UCS), the brittleness index (S₂₀), and aggregate impact value (AIV). Furthermore, the relationship between the mineralogical properties of the rocks and their CCVs were established. It is concluded that the proposed testing methodology is simple and highly repeatable and could be utilized as a pre-design tool in the design stage of the crushing process for rock quarries.     

Parasite fauna of the grey mullet Mugil cephalus L. 1758, and its relationship with some ecological factors in Lower Kızılırmak Delta located by the Black Sea,Turkey

Parasites of the grey mullet Mugil cephalus collected from Lower K?z?l?rmak Delta in Turkey were investigated. Trichodina puytoraci, Trichodina lepsii, Ligophorus mediterraneus, Ligophorus cephali, Gyrodactylus sp., Microcotyle mugilis, Ascocotyle (Phagicola) longa, Haplosplanchnus pachysomus, Diplostomum spathaceum, Tylodelphys clavata, Posthodiplostomum sp., Neoechinorhyncus agilis and Ergasilus lizae were identified. Overall infection prevalence (%), mean intensity and mean abundance values were 99.61%, 458.10 ± 75.72 and 456.30 ± 75.44, respectively. Infection indices of parasite species in relation to season, lakes/lagoons and some physicochemical parameters of water such as temperature, salinity, dissolved oxygen and nitrate are determined and discussed. Posthodiplostomum sp. is a new parasite record for mugilids and Diplostomum spathaceum is the first record in M. cephalus, in the present study. Moreover, Ligophorus mediterraneus, Ligophorus cephali and Ergasilus lizae are new records for Turkish parasite fauna of fish and Mugil cephalus is a new host record for Neoechinorhyncus agilis in Turkey.     

The effects of low concentrations of actinomycin D upon nucleic acid synthesis in different cell types

Résumé L'effet des concentrations faibles de l'actionmycine D sur le pourcentage de cellules dans la phase S pendant un contact de longue durée a été étudié dans 4 souches de cellules. Les résultats montrent que le blocage qui a lieu à la fin de G₁ n'est que temporaire pour les cellules L-strain, mais qu'il dure plus longtemps pour HEp/2, les fibroblasts de la souris et les cellules du rein du singe.     

Enpony and Enchresy

Zusammenfassung Es wird vorgeschlagen, die Freie-Energie-Funktionen vonHelmholtz undGilbert Lewis alsEnponie undEnchresie zu bezeichnen.     

UDP-glucose ceramide glucosyltransferase activates AKT,promoted proliferation,and doxorubicin resistance in breast cancer cells

The UDP-glucose ceramide glucosyltransferase (UGCG) is a key enzyme in the synthesis of glycosylated sphingolipids, since this enzyme generates the precursor for all complex glycosphingolipids (GSL), the GlcCer. The UGCG has been associated with several cancer-related processes such as maintaining cancer stem cell properties or multidrug resistance induction. The precise mechanisms underlying these processes are unknown. Here, we investigated the molecular mechanisms occurring after UGCG overexpression in breast cancer cells. We observed alterations of several cellular properties such as morphological changes, which enhanced proliferation and doxorubicin resistance in UGCG overexpressing MCF-7 cells. These cellular effects seem to be mediated by an altered composition of glycosphingolipid-enriched microdomains (GEMs), especially an accumulation of globotriaosylceramide (Gb3) and glucosylceramide (GlcCer), which leads to an activation of Akt and ERK1/2. The induction of the Akt and ERK1/2 signaling pathway results in an increased gene expression of multidrug resistance protein 1 (MDR1) and anti-apoptotic genes and a decrease of pro-apoptotic gene expression. Inhibition of the protein kinase C (PKC) and phosphoinositide 3 kinase (PI3K) reduced MDR1 gene expression. This study discloses how changes in UGCG expression impact several cellular signaling pathways in breast cancer cells resulting in enhanced proliferation and multidrug resistance.     

Measurement of fibrinolysis in rat system by one-dimensional diffusion method

Zusammenfassung Feststellung, dass die eindimensionale Diffusions-Methode eine sensitive, einfache und reproduzierbare Technik zur Bestimmung der Veränderungen der fibrinolytischen Aktivität bei Ratten ist.     

Effet de quelques anesthésiques sur le flux sanguin de la muqueuse gastrique,chez le Rat

Summary Effects of ether, nembutal or urethane anaesthesia on gastric secretion and mucosal blood flow (MBF) are studied in the Rat; these 3 anaesthetics alter neither volume nor total acidity of juice, but free acidity and proteolytic activity are more importance after ether anaesthesia; MBF is highest in nembutal anaesthetized rats; therefore nembutal is the best anaesthetic for studies of digestive physiology or pharmacology.     

Patient Safety Culture,Evidence-Based Practice and Performance in Nursing

Evidence-based practice is a problem-solving approach in which the best available and useful evidence is used by integrating research evidence, clinical expertise, and patient values and preferences to improve health outcomes, service quality, patient safety and clinical effectiveness, and employee performance. This study aimed to identify the effects of nurses’ patient safety culture perceptions and their evidence-based nursing attitudes on the hospital’s patient safety level and employee performance. A cross-sectional design was employed in this study. Participants included nurses working in a state hospital in Burdur, Turkey, and 218 nurses responded to the research instrument (participation rate: 55.7%). Data were collected through face to face interviews that were conducted from February 20–May 20, 2016. The results of the analyses revealed that evidence-based nursing attitudes and hospital safety culture dimensions explained 29.2% of the total variance in the hospital patient safety level, while evidence-based nursing attitudes and hospital safety culture dimensions explained 15.5% of the total variance in nurse performance. The “evidence-based nursing related beliefs and expectations” aspect of the evidence-based nursing attitude dimension, and the “management support for patient safety” aspect of the patient safety culture dimension were significant predictors of nurses’ performance. The present findings add to the increasing interest in improving evidence-based practice and service quality in order to achieve better patient outcomes.     

Expectations,use and judgmental adjustment of external financial and economic forecasts: an empirical investigation

A survey of 124 users of externally produced financial and economic forecasts in Turkey investigated their expectations and perceptions of forecast quality and their reasons for judgmentally adjusting forecasts. Expectations and quality perceptions mainly related to the timeliness of forecasts, the provision of a clear justifiable rationale and accuracy. Cost was less important. Forecasts were frequently adjusted when they lacked a justifiable explanation, when the user felt they could integrate their knowledge into the forecast, or where the user perceived a need to take responsibility for the forecast. Forecasts were less frequently adjusted when they came from a well‐known source and were based on sound explanations and assumptions. The presence of feedback on accuracy reduced the influence of these factors. The seniority and experience of users had little effect on their attitudes or propensity to make adjustments. Copyright © 2008 John Wiley & Sons, Ltd.     

Diagnosis of diabetes mellitus using artificial neural network and classification and regression tree optimized with genetic algorithm

Diabetes mellitus is one of the most important public health problems affecting millions of people worldwide. An early and accurate diagnosis of diabetes mellitus has critical importance for the medical treatments of patients. In this study, first, artificial neural network (ANN) and classification and regression tree (CART)-based approaches are proposed for the diagnosis of diabetes. Hybrid ANN-GA and CART-GA approaches are then developed using a genetic algorithm (GA) to improve the classification accuracy of these approaches. Finally, the performances of the developed approaches are evaluated with a Pima Indian diabetes data set. Experimental results show that the developed hybrid CART-GA approach outperforms the ANN, CART, and ANN-GA approaches in terms of classification accuracy, and this approach provides an efficient methodology for diagnosis of diabetes mellitus.