基因疗法研究的新进展

指出基因疗法是分子生物学与医用分子遗传学结合的产物,介绍了基因疗法临床应用研究进展,展望了基因疗法的前景,特别强调了上海复旦大学新近取得的基因研究重大突破在推动基因疗法快速发展中的作用。     

Stratigraphy and paleontology of the marine Jurrassic strata in Vietnam

Marine Jurassic strata in Vietnam have yielded characteristic ammonites and occur in: (1) west Quang Binh Province located in the eastern margin of the Nam Theun Basin (the main part of which is located in Middle Laos); (2) the Nong Son Basin situated in the north of the Kon Tum Geoblock; (3) the Da Lat Basin, the largest Jurassic basin in Vietnam, extending from the southern margin of the Kon Tum Geoblock to southeast of Ho Chi Minh City. In the first two, Lower Jurassic marine beds occupy the lower part of the section and grade up into Middle Jurassic red beds. In central Da Lat Basin the section consists completely of marine strata containing many ammonite levels dated from Early Sinemurian to Bajocian, whereas the marginal basin section is like the first two areas. Based particularly on biostratigraphical evidence, a marine transgression is considered to have entered the Indochina Block as early as the Late Hettangian. During the early transgression the fauna was distinctly endemic, showing the separate character of the basins, but since the Late Sinemurian, communication between the Da Lat and other basins was established; the marine regime in Da Lat Basin ended around the Late Bathonian.     

海洋生物工程的巨大潜力及开发动态

论述了海洋在粮食、牧业、药业等方面开发的巨大潜力,介绍了世界上一些国家海洋生物工程的开发动态,提出了我国应采取的对策与建议。     

Vidalols A and B,new anti-inflammatory bromophenols from the Caribbean marine red algaVidalia obtusaloba

Chemical studies of the Caribbean red algaVidalia obtusaloba have resulted in the isolation of two new bromophenolic metabolites, vidalols A and B (1, 2). The new compounds were discovered as part of an organized effort to isolate new naturally-occurring anti-inflammatory agents with a focus upon those which may function through the inhibition of phospholipase A₂.     

不曾想走的路：我与中国科学院

在对个人经历的回顾中,作者顺次介绍了1951—1991年间中国科学院的一些大事以及若干人物,并对中国科学院、中国科学院学部的几次定位,"大跃进"运动对中国科学院的冲击,高端权力对科学工作的非理性干预等进行了分析和反思。     

船舶柴油机废气利用系统热经济分析与优化

借助多产品热能系统的热经济辅助方程，对船舶柴油机废气的单位Yong成材进行了分析，同时通过一实例，对船舶柴油机废气利用系统进行了热经济分析和优化设计。     

Is chlamydial heat shock protein 60 a risk factor for oncogenesis?

Heat shock protein 60 (HSP60) plays an important role in the protein folding of prokaryotic and eukaryotic cells. Most of the papers published on chlamydial HSP60 concern its role in immune response during infection. In the last decade, exposure to Chlamydia trachomatis has been consistently associated with the development of cervical and ovarian cancer. Moreover, it has been suggested that chlamydial HSP60 may have an anti-apoptotic effect during persistent infection. We hypothesize that the accumulation of exogenous chlamydial HSP60 in the cytoplasm of actively replicating eukaryotic cells may interfere with the regulation of the apoptotic pathway. The concomitant expression of viral oncoproteins and/or the presence of mutations may lead to the ability to survive apoptotic stimuli, loss of replicative senescence, uncontrolled proliferation and, finally neoplastic transformation.Received 15 August 2004; received after revision 1 October 2004; accepted 7 October 2004     

基于BP神经网络的海洋声学仪器信号识别方法

分析了几种常用海洋声学仪器信号的基本特征,提出一种基于误差反向传播(back propagation,BP)神经网络,以实现对信号特征参数进行分类、识别的方法.该方法采用短时傅里叶变换提取信号特征参数,运用Levenberg-Marquardt算法训练BP神经网络.以实测海洋声学仪器信号的特征参数进行训练后,采用实测和仿真样本对BP神经网络的识别能力进行测试.实验结果表明,BP神经网络能够有效地区分不同海洋声学仪器的信号,识别准确率达到95%以上,且虚警率低于5%.该研究成果可用于识别海域中不同海洋声学仪器,检测海洋中声学仪器的工作状态.该识别方法对于其他海洋声信号的识别研究也有一定的参考价值.     

中国近代生物学期刊的成型和初具规模时期

目的厘清中国近代生物学期刊在抗日战争前的发生和发展状况,为中国科学史研究提供新线索。方法文献分析与考证法。结果中国近代生物学期刊从最早创办的《生物学杂志》(前身为武昌高等师范学校创办的《博物学会杂志》)至抗日战争爆发,共创办了近60种期刊,以西文发表的原始调查报告及研究论文为主,并出现了《中国科学社生物学研究所丛刊》《静生生物调查所汇报》《中国生理学杂志》等世界名刊。结论中国生物学期刊的成型期是20世纪20年代中期,初具规模时期是20世纪20年代末至抗日战争。在此期间,生物学能够产生世界名刊的主要原因是:能够依托高水平的科研机构,立足本土,并采用当时世界科学界主流语言———西文。