基于B/S结构的在线测试系统的设计与实现

介绍了基于B/S结构的在线测试系统的基本功能和实现方法,给出了系统的应用设计,完成了系统模型的实现.系统具有良好的学生测试和自动评价功能,利用网络数据库的优势解决了群体测试的整体评价.     

国际科技合作中知识转移风险的研究

随着科技全球化的发展和深入,国际科技合作成为各国政府和科研机构提升自身科研水平和核心竞争力的有力途径。然而,在国际科技合作中进行知识的转移与交流时,不可避免的面临着各种各样的风险,如何识别扣防范这些风险成为目前亟待解决的议题。有鉴于此,本文从知识、合作成员和环境三个维度,系统的对国际科技合作中的知识转移风险因素进行了分析,并据此进一步构建出相应的风险防范机制模型,力图为降低国际科技中的知识转移风险提供科学的理论依据。     

Molecular mechanisms of BK channel activation

Large conductance, Ca²⁺-activated potassium (BK) channels are widely expressed throughout the animal kingdom and play important roles in many physiological processes, such as muscle contraction, neural transmission and hearing. These physiological roles derive from the ability of BK channels to be synergistically activated by membrane voltage, intracellular Ca²⁺ and other ligands. Similar to voltage-gated K⁺ channels, BK channels possess a pore-gate domain (S5–S6 transmembrane segments) and a voltage-sensor domain (S1–S4). In addition, BK channels contain a large cytoplasmic C-terminal domain that serves as the primary ligand sensor. The voltage sensor and the ligand sensor allosterically control K⁺ flux through the pore-gate domain in response to various stimuli, thereby linking cellular metabolism and membrane excitability. This review summarizes the current understanding of these structural domains and their mutual interactions in voltage-, Ca²⁺ - and Mg²⁺ -dependent activation of the channel. Received 25 September 2008; received after revision 23 October 2008; accepted 24 October 2008     

爆炸荷载作用下RC单向简支板的优化设计

目前,对爆炸荷载作用下的钢筋混凝土(RC)结构和构件的设计主要采用控制其动力响应最大位移的方法,例如TM-5和ASCE的试算法,类似于静力作用下的极限状态设计法,虽然过程简单,却无法获得最优化的设计.由RC板的抗力-挠度(R-y)曲线分析可知,曲线下方面积代表板在爆炸荷载作用下可能吸收的能量,直接体现RC板抵抗爆炸荷载的能力.采用TM-5和ASCE推荐的单自由度体系简化RC简支单向板,选用双折线模型计算RC板的R-y曲线,分析不同配筋率的R-y曲线下方面积,面积最大时的配筋率即为该设计的最佳配筋率,改变板的几何尺寸,按上述方法分别得出不同设计方案的最佳配筋率.爆炸荷载作用下必须考虑应变率对混凝土和钢筋的应力影响和材料非线性,不能直接应用静力计算中的矩形等效原则简化计算,研究采用分层法迭代求解R-y双折线的特征值.研究成果和分析方法对爆炸荷载作用下的RC板的结构设计和加固设计具有较高的指导价值.     

The utility F-box for protein destruction

A signature feature of all living organisms is their utilization of proteins to construct molecular machineries that undertake the complex network of cellular activities. The abundance of a protein element is temporally and spatially regulated in two opposing aspects: de novo synthesis to manufacture the required amount of the protein, and destruction of the protein when it is in excess or no longer needed. One major route of protein destruction is coordinated by a set of conserved molecules, the F-box proteins, which promote ubiquitination in the ubiquitin-proteasome pathway. Here we discuss the functions of F-box proteins in several cellular scenarios including cell cycle progression, synapse formation, plant hormone responses, and the circadian clock. We particularly emphasize the mechanisms whereby F-box proteins recruit specific substrates and regulate their abundance in the context of SCF E3 ligases. For some exceptions, we also review how F-box proteins function through non-SCF mechanisms.     

基于S3C2410构建PDA数据采集节点系统

描述了以现代的无损检测技术为基础,以S3C2410为核心构建的PDA数据采集系统。该系统实现了无线网络节点的数据采集功能。在此基础上设计了一套PDA数据采集,其硬件结构由S3C2410、无线网络节点和通信模块等组成;系统软件分为驱动程序模块、通信协议模块等,可应用于高校的教室温度采集系统。     

Genus Baseodiscus (Nemertea: Heteronemertea): Molecular identification of a new species in a phylogenetic context

A new heteronemertean, Baseodiscus jonasii sp. nov., is described from Guadalcanal, Solomon Islands. It resembles B. delineatus in inner morphology but can be distinguished from this species by its different colour pattern and differences in the nucleotide sequence of the mitochondrial 16S rRNA gene. The monophyletic status of the genus is investigated by reconstructing the phylogeny of six specimens from four species assigned to this genus, together with 22 specimens from nine other heteronemertean genera, using parsimony and Bayesian analysis. The results imply that Baseodiscus is a monophyletic group while several other heteronemertean genera are non‐monophyletic.     

一个已加强的Hardy-Hilbert不等式的改进

利用改进的Holder’s不等式,对一个已加强的Hardy-Hilbert不等式作了进一步改进,建立了一个新的不等式.     

美国国家实验室发展经验对中国强化国家战略科技力量的启示

在探索国家战略科技力量的定义与历史演进的基础上,探讨了美国国家实验室建设发展的经验,分析了中国国家战略科技力量发展面临的使命和存在的问题,提出了中国发展国家战略科技力量的相关建议。     

南水北调中线工程向黄河相机补水政策的探讨

针对黄河流域水资源贫乏的现状,分析了南水北调中线工程向黄河相机补水的必要性和可行性,进而提出了相关的政策建议。