水上运动员身心反应与细胞免疫功能的测定

在赛前大运动量训练状态下, 对 30 名有比赛任务的赛艇、 皮划艇男女运动员进行 SCL- 90 身心应急反应测评与外周血T 淋巴细胞亚群进行测定, 并与以同等运动量随队训练 32名男女运动员对照,结果发现: ( 1) 赛前训练组其 SCL-90 总分,阳性项目数和躯体焦虑、 抑郁、 恐惧、 强迫等症状明显高于对照组( p < 0.05~ 0.01) ; ( 2) 赛前训练组 T 淋巴细胞亚群中 CD₃, CD₄ , CD₄ / CD₈明显低于对照组( p< 0.05~ 0.01) , CD₈高于对照组( P < 0.01) ,这一细胞免疫功能低下主要影响因素可能是由于赛前训练中社会心理因素所致.     

一种基于神经网络的无线TCP性能改进机制

传统TCP拥塞控制机制由于无法区分拥塞丢包与无线误码丢包,使其在无线环境中传输性能急剧恶化。从避免无线误码丢包出发,提出一种利用传统拥塞控制机制得到的参数（往返时间、重传数据量、拥塞窗口等）,基于无线环境的误码情况和神经网络算法进行TCP段尺寸调整的TCP性能改进方案。仿真结果表明,基于神经网络的TCP改进机制性能得到明显改善。     

一种基于成长型神经网络的曲面重建快速算法

文章使用成长型神经网络来实现曲面的快速重建,在重建过程中采用线性组合的方式分裂节点;使用一种简化的方法计算节点的Voronoi区域面积,以用来分配新增节点的计数器值;最后对生成的曲面进一步综合优化。实验结果表明,使用该算法能够快速获得形状良好的曲面。     

Interactions of the cell adhesion molecule nectin with transmembrane and peripheral membrane proteins for pleiotropic functions

Cell adhesion molecules (CAMs) have been implicated in the control of a wide variety of cellular processes, such as cell adhesion, polarization, survival, movement, and proliferation. Nectins have emerged as immunoglobulin-like CAMs that participate in calcium-independent cell-cell adhesion by homophilic and heterophilic trans-interactions with nectins and nectin-like molecules. Nectin-based cell-cell adhesion exerts its function independently or in cooperation with other CAMs including cadherins and is essential for the formation of intercellular junctions, including adherens junctions, tight junctions, and puncta adherentia junctions. Nectins cis-interact with integrin α_vβ₃ and platelet-derived growth factor receptor and facilitate their signals to regulate the formation and integrity of intercellular junctions and cell survival. Nectins intracellularly associate with peripheral membrane proteins, including afadin and Par-3. This review focuses on recent progress in understanding the interactions of nectins with other transmembrane and peripheral membrane proteins to exert pleiotropic functions. Received 27 June 2007; received after revision 14 August 2007; accepted 12 September 2007     

Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-Cadherin

Formation of appropriate neural circuits depends on a complex interplay between extracellular guiding cues and intracellular signaling events that result in alterations of cytoskeletal dynamics and a neurite growth response. Surface-expressed cell adhesion molecules (CAMs) interact with the surroundings via the extracellular domain and bind to the cytoskeleton via their intracellular domain. In addition, several CAMs induce signaling events via direct interactions with intracellular proteins or via interactions with cell surface receptors. Thus, CAMs are obvious candidates for transmitting extracellular guidance cues to intracellular events and thereby regulating neurite outgrowth. In this review, we focus on two CAMs, the neural cell adhesion molecule (NCAM) and N-cadherin, and their ability to mediate signaling associated with a neurite outgrowth response. In particular, we will focus on direct interaction between NCAM and N-cadherin with a number of intracellular partners, as well as on their interaction with the fibroblast growth factor receptor (FGFR). Received 23 May 2008; received after revision 14 July 2008; accepted 21 July 2008     

The translocation motif of hepatitis B virus improves protein vaccination

Cell-penetrating peptides (CPPs) have been shown to improve antigen loading of dendritic cell vaccines. Here we asked whether fusion of a CPP to a protein improves its immunogenicity when this fusion protein is directly applied as vaccine. We used the cell-penetrating translocation motif (TLM) derived from the hepatitis B virus, because no size limitation of cargos has been observed. Increased immunogenicity was observed when TLM was fused to ovalbumin (TLM-ova). TLM-ova was found to be superior to ova in inducing proliferation and cytotoxicity of ova-specific CD8+ T cells in vitro and in vivo. Using ovalbumin-expressing thymoma cells (EG7-ova), an improved anti-tumor immune response was observed for TLM-ova vaccination versus vaccination with ova. Moreover, TLM-ova vaccination induced a higher titer of anti-ovalbumin IgG2a antibodies compared to ova. These data demonstrate that CPP-protein vaccines can improve cellular as well as humoral immune responses. Received 16 November 2005; received after revision 12 December 2005; accepted 10 January 2006 †These authors contributed equally to this work     

竹材细胞壁晶区变化规律的研究

对不同生长期的毛竹进行定期采样,应用偏振光显微镜及图像处理技术研究毛竹横截面维管束结晶区的变化规律。结果表明:毛竹生长初期,厚壁细胞结晶比例的变化呈现线性增加;进入中龄期,毛竹开始木质化,纤维素比例降低,竹材厚壁细胞壁结晶比例减少;到了后期毛竹木质化降低,毛竹结晶比例变化趋于缓慢并基本保持不变。     

GaAs太阳电池减反射膜的设计

利用实际测量的光谱响应结果来对GaAs单结太阳电池减反射膜进行设计优化.先初步设计单结GaAs太阳电池SiN减反射膜厚度,然后太阳电池片样品进行光谱响应测量.利用实际测量的光谱响应结果推算电池样品在AM1.5条件下的无反射时光谱响应,根据计算的结果来对GaAs单结太阳电池减反射膜厚度进行设计优化.优化结果表明83nm为GaAs单结太阳电池单层减反射膜厚度的最优值.     

基于推覆分析的柱尺寸对隔震框架结构抗震性能影响

现有隔震结构的研究主要集中于隔震支座,较少考虑上部结构力学特性对整个隔震建筑抗震性能的影响。本文设计了符合规范要求的隔震RC框架结构并依次增大柱尺寸,研究柱尺寸对隔震结构抗震性能的影响。本文利用SAP2000对四个隔震模型分别使用倒三角加载模式和均匀分布加载模式进行Pushover分析,并使用能力谱法评估隔震结构抗震性能。研究结果表明在相同的顶点位移时,隔震结构承受的剪力更小,因而抗震性能比普通结构更优越;通过分析隔震结构塑性铰开展及层间位移变化情况,增大柱尺寸使隔震结构破坏减轻,改善了隔震结构尤其是结构首层的抗震性能;随着柱尺寸越来越大,层间位移减小幅度递减,即抗震性能改善效果减弱。因此,柱尺寸600mm基础上增加10%的方案对隔震结构抗震性能提升最为明显。     

羊胎盘活细胞素微量元素和氨基酸组成的分析

通过ICP和HPLC对羊胎盘活细胞素的微量元素和氨基酸组成进行了定量分析,证明它含有14种微量元素,其中8种是人体必需的微量元素;含有16种氨基酸,其中必需氨基酸7种,约占氨基酸的33．5％。表明羊胎盘活细胞素的有效成分种类齐全,含量高,具有良好的营养价值,值得进一步开发应用。