Progress in crystallization of major histocompatibility complex class I in vertebrates

The major histocompatibility complex(MHC)of proteins that exists in all vertebrates is encoded by a cluster of genes associated with the immune response and related functions.MHC is divided into MHC I,II,and III;MHC I is involved in antigenic presentation,binding T cell receptors,and leading ultimately to specific cellular immune responses.The complicated functions of MHC I are determined by the nature of the complex.The crystal structure of MHC I has been solved for many animals,revealing the relationship between spatial structure and function.MHC I consists of an a heavy chain and a b2m light chain,both ligated non-covalently to a complex when a peptide is bound to the antigenic-binding groove.The a heavy chain is divided into an extracellular domain,a transmembrane domain,and an intracellular domain.The extracellular domain consists of sub-regions a1,a2,and a3.The a1 and a2 together form the antigenic-binding groove and bind antigenic peptides with 8–10 amino acid residues.MHC I can form a stable spatial structure;however,it should be noted that there are differences in the structure of MHC I among animal species,including anchored amino acids in binding peptides,binding sites,molecular distance,crystallization conditions,etc.Here,progress in determination of the crystal structure of human,mouse,chicken,non-human primate,and swine MHC I is described in detail.     

树计划技术──工作分解结构进度计划模拟分析与优化

综合工作分解结构(WBS)概念、项目管理网络计划技术(CPM/PERT)、MonteCarlo模拟方法、直接搜索算法和计算机技术等, 本文创建一种新的项目管理技术─-项目管理树计划技术, 研讨活动树模型、时间参数算法、模拟寻优、项目进度计划优选等有关概念和方法。     

论藏族传统绘画作品的"经验断代分类法"

藏传绘画不仅是藏族艺术的珍贵遗产，也是研究藏族化的重要形象资料和活的“标本”。目前，国内外学对传统绘画作品进行断代研究主要以经验断代分类法和自然科学手段断代分类。章中作结合多年的研究与教学实践经验，对西藏传统绘画作品的“经验断代分类法”进行了探讨。     

预应力砼建筑结构的设计与PRCS的使用

本文介绍了应用“预应力砼建筑结构设计系列软件（ＰＲＣＳ）”进行结构的预应力筋方案设计与优化的方法．     

近3000年来中国气候变化及对社会经济发展的影响综述

本文对近3000年来气候变化以及重大自然灾害发生的规律性，尤其是近五百年的小冰期的气候特点进行了总结和分析，并对气候变化对社会经济影响的研究成果加以概括，在此基础上提出了自己的观点和设想，以期对人类的生产生活产生一定的指导意义．     

论贵州农业资源环境特征与农业的可持续发展

在分析贵州农业资源与农业生态环境特征的基础上,阐述了贵州农业经济现状与持续发展所面临的困难,揭示出贵州农业经济结构与农业资源环境结构之间不相适应的矛盾。从而影响着贵州农业资源的高效利用和转化效率。为实现农业的可持续发展,贵州应将农业生产的持续性、农村经济的持续性和生态环境的持续性三者有机地统一。并提出了贵州农业可持续发展的目标与途径。     

A Robust Algorithm in Active Queue Management

A variable structure based control scheme was proposed for Active Queue Management （AQM） by using sliding model algorithm and reach law method. This approach aims to address the tradeoff between good performance and robustness with respect to the uncertainties of the round-trip time and the number of active connections. Ns simulations results show that the proposed design significantly outperforms the peer AQM schemes in terms of fluctuation in the queue length, packet throughput, and loss ratio. The conclusion is that proposed scheme is in favor of the achievement to AQM objectives due to its good transient and steady performance.     

构造地质

研究区正置ＮＥ向牟平──即墨断裂带上，褶皱复杂，断裂十分发育。ＮＥ向深断裂控制了区内４个花岗岩体分布；ＮＥ向及Ｅ—Ｗ向深断裂控制了中生代盆地展布。胶东群变质岩，元古代重熔花岗岩及交代花岗岩内的ＮＮ向、ＮＮＥ向相关剪切带中发育的蚀变糜棱岩化花岗岩带或断裂空间，是蚀变岩型金矿化及石英脉型金—银矿化的定位空间。Ｅ—Ｗ向深断裂旁侧的产于Ｋ１Ｌ１含炭岩系中先挤压后扭张的构造空间是新类型金矿产出空间。     

过程成象技术现状与展望

对过程成象 ( PT)系统的基本原理及系统组成、基本特点和应用进行了分析。简要分析了各类 PT技术的发展现状和存在的问题。阐述了其优点和工业应用前景。