Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

The controlling factors and distribution prediction of H2S formation in marine carbonate gas reservoir, China

Generally, there are some anhydrites in carbonate reservoir, as H2S is also familiar in carbonate oil and gas reservoirs. Nowadays, natural gas with high H2S concentration is usually considered as TSR origin, so there is close relationship between H2S and anhydrite. On the contrary, some carbonate rocks with anhydrite do not contain H2S. Recently, researches show that H2S is only a necessary condition of H2S formation. The reservoir porosity, sulfate ion content within formation water, reservoir temperature, oil/gas and water interface, hydrocarbon and some elements of reservoir rock have great controlling effects on the TSR occurrence. TSR deoxidizes hydrocarbon into the acidic gas such as H2S and CO2, and the H2S formation is controlled by TSR occurrence, so the relationship among reaction room, the contact chance of sulfate ion and hydrocarbon, the reservoir temperature has great influence on the TSR reaction. H2S has relatively active chemical quality, so it is still controlled by the content of heavy metal ion. Good conditions of TSR reaction and H2S preservation are the prerequisite of H2S distribu- tion prediction. This paper builds a predictive model based on the characteristic of natural gas reservoir with high H2S-bearing. In the porosity reservoir with anhydrite, the formation water is rich in sulfate and poor in heavy metal ion. Oil and gas fill and accumulate in the gas reservoir with good preservation conditions, and they suffered high temperature later, which indicates the profitable area of natural gas with high H2S-bearing.     

铁路主要干线提速有关问题的研究

在对列车提速的必要性、原则和有限目标进行论述的基础上，就列车提速对运输技术设备的要求和运输组织方面的若干问题进行了初步探讨，分析了多速度客货列车混跑时，不同速度配比的组合方案对线路通过能力的影响，为干线提速的方案选定提供了基础     

神经网络在可靠性分析中的应用

应用人工神经网络对舰炮发生故障的发射炮弹数进行了预测。借助前馈神经网络对非线性函数的逼近能力，对发生故障的发射炮弹数进行了单步预测，并与使用灰色数列预测的结果进行了对比，验证了人工神经网络进行可靠性预测的可行性。     

变频调速在连铸改造中的应用

针对连铸生产中存在的问题,设计用变频调速系统取代直流调速系统.阐述了系统的构成和工作过程,实现PC对变频器的控制和两台变频器间的连锁控制,并给出了PC控制程序框图.实际运行结果表明:本系统安全可靠、故障率低、性能优于原直流系统.     

斜坡变形破坏的预测及防护

通过对斜坡变形破坏和影响因素的研究，探讨工程建设中斜坡变形破坏的预测及防护。     

再论从物理角度分析跳远成绩

建立2个坐标系，从力学原理分析起跳时的角度、初速度与跳远成绩的关系，同时与郑亚晨的文章的理论分析进行商榷。     

浅析篮球运动员的快速能力

快速能力是篮球运动员的最基础的竞技能力 ,因此 ,培养训练篮球运动员的快速能力是非常重要的 .快速能力主要包括 :移动速率 ;反应、判断力 ;果断性、合理性 ;攻守转换的速度等 .在训练中 ,应根据球队队员的特点进行 ,做到个性与共性的有机结合 ,使其得到最大限度的提高     

基于RBF网络的混沌时间序列的建模与多步预测

提出将RBF神经网络应用于混沌时间序列的建模与预测中 ,设计了一个三层RBF网络结构 ,说明了RBF网络用于混沌时间序列建模和预测时的基本性质。仿真结果表明 ,RBF网络模型对混沌时间序列有比较强的拟合能力和比较高的一步及多步预测精度。采用RBF网络进行混沌时间序列的建模和预测能够取得比其它方法好得多的效果。     

离心式风机导流器调节的经济性分析

全面分析和比较了G4－73型离心风机在较大负荷变化范围内分别采用轴向导流器调节和轴向导流器加双速电动机调节的运行经济性，对各种风机的节能具有重要的指导意义。