Research advances in gene therapy for Parkinson's disease

During the long period of time when people have been seeking for an effective therapeutic method for PD, the gene therapy has shown greater and greater advantages over other methods. It can be performed mainly in two ways: ex vivo and in vivo. With the former, TH gene as well as some neurotrophic factor genes (such as GDNF, BNDF genes) can be invited to some cell lines or primary cells thus forming engineered cells and then implanting them into brain. While with the latter, viral vectors including HSV-1, Ad, AAV that can be utilized to construct recombinant viruses, or non-virus vectors can be used to delived DNA into brain directly. The present review summarizes the recent research advances in the gene therapy for PD, and it is reasonable for us to predict a notable progress in prevention and treatment for PD in the next decade.     

Neuropeptide Y receptors in a protozoaStylonychia mytilus

Radio ligand binding assays(RLBA) were used to study neuropeptide Y (NPY) receptors in a protozoa Stylonychia mytilus. The experimental results showed that 2-3×10+3/mL Stylonychia cells incubated in Pringsheim solution which contained 3H-NPY could specifically bind 3H-NPY and concomitantly present saturable characteristic. This suggested that Stylonychia possessed some specific binding sites for NPY. Scatchard transformations of binding assay for the NPY receptors at 25℃ are compatible with the specific activity of 42.47 fmol/10+3 cells and the binding equilibrium constant of 0.113 nmol/L. The data of 125I-NPY binding assay to the membrane protein extract of Stylonychia indicated that there was a significant difference between the amount of total bound and nonspecific bound of 125I-NPY. This result indicated that NPY receptors were probably localized mainly on the cell membrane.     

Third-order optical nonlinearities for lanthanum (Ⅲ) complexes with 1,10-phenanthroline components

The nonlinear refractive indexes n 2 for the ethanol solutions of 1,10-phenanthroline (2.0×10 -3 mol·L -1), [bis(1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1), and [nitrato-fluoracil-bis (1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1) are first measured, the third-order nonlinear optical susceptibilities χ (3) and <γ> are calculated, and the mechanisms of the third-order optical nonlinearities enhanced by lanthanum (Ⅲ) are discussed preliminarily.     

十八烷基（2—亚硫酸）乙基二甲基铵的合成

由Ｎ,Ｎ－二甲基十八烷基胺和乙撑亚硫酸酯反应合成十八烷基（２－亚硫酸）乙基二甲基铵是一种新型的亚硫酸内酯型两性表面活性剂,经红外光谱和核磁共振谱分析,确定了该化合物的结构,该两性表面活性剂合成方法简单,原料易得,用途广泛,有发展前途。     

FMS装卸工作站研制中的工业造型设计

简单介绍了柔性加工系统的概念和组成,以及本系统中装卸工作站的要求。归纳了工业设计理论发展,充实,完善的过程,提出了现代工业设计应遵循工业设计三原则,针对不同产品,从里到外,从外到里,反复设计的观点。论述了这一设计理论在ＦＭＳ装卸工作站设计中的实践。最后说明实践成果。     

成组技术中面向对象的参数化模型

针对传统成组技术中的编码系统难以使用、编码不够精确和重用困难等问题,提出在成组技术中构造面向对象的参数化模型．该模型用类来描述零件簇,构成零件类的结构层次,生成零件描述的框架;用参数化方法从零件类实例化生成对象,以对象来表示具体的零件;查询时,以零件的特征和零件的具体参数来驱动,加速搜索的过程,并使结果更加精确;找到相同或相近零件对象后,在某个类层次上重用以前的设计．该模型的提出为成组技术的应用提供了新的途径．     

基于任务的产品工艺设计过程管理

在分析产品工艺设计流程现状的基础上,研究了现有ＣＡＰＰ系统中工艺过程设计和过程管理,提出了任务驱动型的ＣＡＰＰ思想．认为工艺设计的过程本质上是对任务完成过程的集合,通过对任务的生成、监控、设计、提交、签审、发放,正好控制工艺设计的流程,并在ＣＡＰＰ系统开发中进行了成功的尝试,为工艺设计的管理提供了一种可行的方法．     

（H,G）—变换和拟正则半群

研究一般的（Ｈ,Ｇ）型变换通过适当合成变换后生成拟正则半群;并建立了Ｇ－变换和（Ｈ,Ｇ）型变换两者之间的拟共形共轭关系．对于给定的一个拟正则半群,构造了一个不变共形结构ＧΓ,使得该半群中的每个元素在这个不变共形结构下保持Ｇ－变换不变．     

商标图象库检索的多层次结构方法

基于商标图象库应用背景和具体特征,提出一种商标图象检索的多层次方法．图象预处理阶段采用人机交互方式下３种半自动方法提取商标图象各区域对象．检索首先采用字符串匹配方法和传统数据库查询技术,动态减少图象搜索范围;在图象区域规格化下,相继用最小约束矩和基于Ｈａｕｓｄｏｒｆ距离的相似性函数度量商标相似性程度,具有平移、旋转和尺度变换下的不变性和一定的抗噪声能力．实验结果表明,该方法有效和实用．     

综合智能网络管理系统模型的设计

在对传统的网络管理系统方案（基于ＳＮＭＰｖ１或ＳＮＭＰｖ２,ＲＭＯＮ网络管理技术）进行分析的基础上,详细说明了传统网络管理系统存在的缺点,提出一种新型实用的综合智能网络管理模型,将传统的基于ＳＮＭＰ,ＲＭＯＮ网络管理技术,基于Ｊａｖａ的网络代理技术和专家系统的基本规则（ＲｕｌｅＢａｓｅｄＲｅａｓｏｎｉｎｇ,ＲＢＲ）或基于事例（ＣａｓｅＢａｓｅｄＲｅａｓｏｎｉｎｇ,ＣＢＲ）技术相结合,对网络系统实施