徐州市经济发展现状及对策研究

本文评价了影响徐州市经济发展的自然和人文诸条件,深入分析了徐州市经济发展的现状和存在问题。并有针对性地提出解决问题的途径。     

一维周期调制磁场中二维电子气的热学输运特性

在线性响应理论的框架内讨论了一维调制磁场中二维电子气的热电系数Ｓμｖ，热传导系数ｋμｖ及热阻系数（ｋ＾－１）μｖ等热力学输运特性。结果表明，由于磁场调制部分的存在，使二维电子气的热力学输运系数中除了通常ＳｄＨ振荡特性外，还表现出与磁场调制周期相关的新的振荡特性，即Ｗｅｉｓｓ振荡。     

我国海上油田集输设施费用测算方法探讨

本文对我国海上油田开发的可行性研究和经济评价中如何测算集输设施费用问题,用实际资料结合经济计量学方法,提出了三种测算式供实测选用,并建议用以油轮为主的测算式供今后推广。     

氯接触池中溶质输移与消毒过程的数值模拟

为使饮用水处理中氯接触池达到较高的掺混和消毒效率 ,提出一种数学模拟方法。采用二维水流动量方程和连续方程、自由氯的反应过程一阶动力学方程和细菌数量衰减过程的 Chick- Watson公式等组成的模型 ,计算了氯接触池中溶质输移与消毒过程。对 3种涡粘性湍流模型与 3种差分格式的不同组合下计算所得到的多组模拟结果进行了分析 ,并与试验数据进行了比较。研究表明 :通过数值方法对池内的水流紊动结构及自由氯输运、反应和细菌生灭等过程进行计算模拟 ,与仅依据不同设计方案所得滞留曲线进行评价的做法相比 ,更有利于比较内部细节的设计 ,方便地判定不同设计方案的运行效率     

Aspartate 338 contributes to the cationic specificity and to driver-amino acid coupling in the insect cotransporter KAAT1

To investigate the peculiar ionic specificity of KAAT1, an Na⁺- and K⁺-coupled amino acid cotransporter from Lepidoptera, a detailed analysis of membrane topology predictions was performed, together with sequence comparison with strictly Na⁺-dependent mammalian cotransporters from the same family. The analysis identified aspartate 338, a residue present also in the other cotransporter accepting K⁺ (CAATCH1), but absent in most mammalian transporters that have, instead, an asparagine in the corresponding position. Mutation of D338 in KAAT1 led either to non-functional transporters (D338G, D338C), or to an altered ionic selectivity (D338E, D338N), observable in uptake experiments and in electrophysiological properties. In particular, in D338E, the transport activity, while persisting in the presence of Na⁺, appeared to be completely abolished in the presence of K⁺. D338E also showed uncoupling between transport-associated current and uptake. The opposite mutation in the -aminobutyric acid transporter rGAT-1 (N327D) resulted in complete loss of function. In conclusion, aspartate 338 in KAAT1 appears to be important in allowing K⁺, in addition to Na⁺, to drive the transport mechanism, although other residues in different parts of the protein may also play a role in the complete determination of ionic selectivity.Received 23 September 2003; received after revision 11 November 2003; accepted 25 November 2003     

Ectoprotein kinase-mediated phosphorylation of FAT/CD36 regulates palmitate uptake by human platelets

Glycoprotein IV (FAT/CD36) has been shown to be phosphorylated by a cAMP-dependent, platelet membrane-bound ectokinase. In this study, we demonstrate that ectophosphorylation of FAT/CD36 regulates initial palmitate uptake. This is the first time that short-term regulation of the activity of a long-chain fatty acid carrier could be shown. Phosphorylation of FAT/CD36 was paralleled by a significant decrease in initial palmitate uptake by morphologically and functionally intact platelets. Maximum inhibition of palmitate uptake was achieved at 0.5 nM extracellular ATP, being significantly decreased to 72% compared to the control. Inhibition of palmitate uptake was abolished by co-incubation with the specific protein kinase A inhibitor peptide PKI or with β,γ-methylene-ATP, and was reversible upon addition of alkaline phosphatase. An extracellular ATP concentration above 5 μM completely prevented the ectophosphorylation-mediated inhibition of palmitate uptake. We conclude that FAT/CD36-mediated palmitate uptake by human platelets is short-term regulated via cAMP-dependent ectophosphorylation of FAT/CD36. Received 18 July 2002; received after revision 29 August 2002; accepted 19 September 2002 RID="*" ID="*"Corresponding author.     

Receptor binding, internalization, and retrograde transport of neurotrophic factors

This review deals with the receptor interactions of neurotrophic factors, focusing on the neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic factor (GDNF) family, and the ciliary neurotrophic factor (CNTF) family. The finding that two proteins, p75^NTR and Trk, act as receptors for NGF in neurons generated the discovery of other neurotrophic factors/receptor families and has enhanced our understanding of the development, survival, regeneration, and degeneration of the nervous system. The kinetics of binding, the structure of the ligand-receptor complex, and the mechanism of retrograde transport of the neurotrophins are discussed in detail and compared to information available on the GDNF and CNTF families. Each neurotrophic factor family, i.e., NGF, GDNF, and CNTF, has a set of receptors with specificity for individual members of the family and a common receptor without member specificity that, in some families, generates the cellular signal and retrograde transport.     

一种基于内容的视频信息检索技术的研究

在多媒体技术迅速发展的今天,作为多媒体信息中最复杂的视频信息,用传统的文件检索方法已无法满足用户的查询要求,而新的基于内容的检索技术将更好地满足视频信息的查询和检索．文章从基于内容的检索中用户的查询要求出发,将视频流划分成多个视频段,用对象和事件来表达每个视频段的视频内容,并在考虑时态特性的基础上,提出新的索引结构和查询算法,以有效地支持基于内容的检索和查询。     

双辊薄带下不锈钢铸轧过程的耦合数值模拟

采用有限元法模拟了双辊铸轧不锈钢过程的流热耦合问题;分析了铸轧速度对熔池内流场、温度场的影响以及流场与温度场之间的相互影响;给出了凝固过程中熔池与铸轧辊之间的热流密度变化趋势及随铸轧速度的变化规律,并把此模拟的结果与试验的结果相比较,吻合较好;通过熔池内温度场及温度梯度分析了熔池内凝固的发展及其对热流密度变化的影响·此模拟结果可以为控制铸轧过程的稳定提供有效的数据     

头肩视频图像的运动物体自动提取

介绍、比较区域分割、运动分割和物体分割的概念及其在视频序列图像分割中的应用。分析说明各种运动状态下帧差图像与相应帧灰度图像的关系。提出了基于帧差图像边缘与灰度图像边缘之间强相关性的运动物体边界自动跟踪、提取算法。利用运动物体边界的闭包分割、提取运动物体。提出了多层次运动物体描述的思想。