Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

关于极限的几个定理

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球电流壳磁场的计算

计算的结果表明，球壳内的磁场是均匀的，可用此方法在一定范围内获得均匀磁场．     

Solving the State Equation of a System by Walsh Function

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原子结构中的物理理论

本文较系统地介绍了有关原子结构方面的一些基础理论,由定性到定量,并应用量子力学知识描绘了原子结构状态。     

强伪凸函数的某些性质

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OFDM系统中的峰值平均包络功率比上下界的分析

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基于多尺度随机模型具有有效性和高度并行算法这一优势，提出如何用三阶树多尺度模型来表示1-D Reciprocal过程；并如何获得多尺度模型的参数。这就为具有Markov统计特性的信号或过程建立起一般的三阶树多尺度随机模型，为更有效的解决实际问题提供了理沦基础，同时，给出了一类定义在单位区间上的随机过程三阶树多尺度表示的仿真示例。     

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