全文获取类型
收费全文 | 9888篇 |
免费 | 397篇 |
国内免费 | 880篇 |
专业分类
系统科学 | 1085篇 |
丛书文集 | 281篇 |
教育与普及 | 32篇 |
理论与方法论 | 16篇 |
现状及发展 | 127篇 |
综合类 | 9615篇 |
自然研究 | 9篇 |
出版年
2024年 | 37篇 |
2023年 | 93篇 |
2022年 | 125篇 |
2021年 | 157篇 |
2020年 | 188篇 |
2019年 | 156篇 |
2018年 | 146篇 |
2017年 | 216篇 |
2016年 | 228篇 |
2015年 | 273篇 |
2014年 | 468篇 |
2013年 | 402篇 |
2012年 | 643篇 |
2011年 | 623篇 |
2010年 | 472篇 |
2009年 | 591篇 |
2008年 | 628篇 |
2007年 | 822篇 |
2006年 | 705篇 |
2005年 | 606篇 |
2004年 | 473篇 |
2003年 | 458篇 |
2002年 | 366篇 |
2001年 | 284篇 |
2000年 | 260篇 |
1999年 | 244篇 |
1998年 | 195篇 |
1997年 | 184篇 |
1996年 | 173篇 |
1995年 | 153篇 |
1994年 | 124篇 |
1993年 | 126篇 |
1992年 | 105篇 |
1991年 | 109篇 |
1990年 | 102篇 |
1989年 | 73篇 |
1988年 | 67篇 |
1987年 | 49篇 |
1986年 | 27篇 |
1985年 | 9篇 |
1981年 | 1篇 |
1955年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 343 毫秒
11.
王佐芳 《山东理工大学学报:自然科学版》2005,19(4):107-110
最佳资金结构的确定,关系到股份制企业资金成本的高低和财务风险的大小.如何通过筹资发挥财务杠杆的作用,确定最佳资金结构是股份制企业筹资决策的关键.针对这一问题,比较详细地介绍了每股利润分析法、比较资金成本法在确定最佳资金结构中的运用. 相似文献
12.
《科学通报(英文版)》2008,(19)
The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors. 相似文献
13.
Architecture, engineering, and construction (AEC) global project teamwork is communication intensive and relies heavily on synchronous and asynchronous information and collaboration technologies (ICT). We explore in this paper how an asynchronous ICT, called ThinkTank, reshaped the work practice of design-construction global teams, and how the interaction with this ICT reshaped the purpose and benefits of its use. ThinkTank is a web-based asynchronous collaboration and discussion forum. We introduce the influence diffusion model (IDM) that formalizes the process of identifying the influence of people, messages, and terms mathematically. Discovering who the influence leaders in project teams are can be beneficial and critical from a corporate management perspective, since they can guide or motivate the team towards successful actions and outcomes. We present the ThinkTank-IDM integrated system and its validation with a testbed of 53 AEC global team project archived in ThinkTank over 8 years. 相似文献
14.
《科学通报(英文版)》2006,(5)
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) IS A VERY IMPORTANT TOPIC FOR MANY SCIENTIFIC FIELDS AND CAN BE TERMED AS QUANTITATIVE SEQUENCE ACTIVITY MODELS(QSAM)[1] WHEN REFERRED TO THE RESEARCH ON RELATION- SHIPS BETWEEN STRUCTURES AND ACTIVITIES OF BIOLOGICAL MOLECULES, SUCH AS PROTEINS, AND NUCLEIC ACIDS. HOW- EVER, IT IS VERY DIFFICULT TO ESTABLISH A QSAM MODEL,… 相似文献
15.
本文提出了流体力学解析边界拟合坐标系方法,及建立在这种坐标系基础上对流动方程进行摄动处理的方法,并列举几种流动建立了解析边界拟合坐标系中的方程。 相似文献
16.
田至美 《首都师范大学学报(自然科学版)》1993,(3)
拟定了贫困地区经济发展中主导产业选择的五条原则,并提出了选择主导产业的一种方法,即先通过列表评分法求出各产业的优势度,再利用层次分析法确定各产业在合理发展工业中所占的相对地位,最后将两种结果相互参照确定主导产业部门。 相似文献
17.
本文从椭偏光合矢量旋转角速度Ω的表达式出发,对只有沿椭圆长、短轴方向的椭偏光合矢量间的相位差才为的难点给出了证明 相似文献
18.
19.
20.
讨论了Sasakian空间形式中具有平行平均曲率向量的C-全实子流形,得到了紧致的C-全实子流形的一个刚性结果. 相似文献