具有C2v对称性二苯并噻吩衍生物的合成及光学特性

以二苯并噻吩为原料合成了中间体2,8-二溴二苯并噻吩和2,8-二甲酰基二苯并噻吩，并从这两种化合物出发，分别利用Heck反应和Wittig反应合成了具有C_2v对称性的一系列二苯并噻吩衍生物。用核磁共振、红外、质谱等光谱手段表征了新化合物的结构，对这些化合物的光物理特性进行了评价。结果表明：2，8-二［2-(吡啶-4-基)乙烯基］二苯并噻吩（I）的紫外吸收峰随着溶剂极性的增加而出现蓝移现象，而其他化合物的紫外吸收峰随溶剂极性增加往长波方向移动；化合物I具有较低的荧光量子效率；用750～920nm的飞秒激光激发时化合物I的溶液表现出明显的双光子吸收特性。     

肿瘤转移相关基因CD44v6与p53在胃癌组织中的表达和预后

目的探讨肿瘤转移促进基因CD44v6和肿瘤转移抑制基因p53在胃癌组织中的表达与预后.方法45例浸润性胃癌组织来自哈尔滨医科大学附属第二医院病理科.采用sABC方法进行CD44v6和p53免疫组织化学检测.结果CD44v6在胃癌组织中表达率为53.3%(24/45).其中低分化腺癌伴印戒细胞癌的表达率高(16/24,66 7%).p53在胃癌组织中的表达率为75.6%(34/45),而在组织学的分型方面无明显差别.结论p53是最先参与肿癌侵袭和转移的抑癌基因.CD44v6具有在不同组织学类型的胃癌中表达率不同的特点,结果表示CD4v6的表达率可判断不同组织学类型胃癌的预后.     

Psychophysiological reactivity in Type A and B women during a rapid information processing task

Summary Type A and Type B women assessed by a newly developed German questionnaire need for control (NC) were compared with respect to time-pressured information processing performance and to simultaneously recorded psychophysiological reactivity. The task was computer controlled, monetarily reinforced and subject paced. The physiological measurements included the cardiovascular parameters, ECG and finger plethysmographic amplitudes and the noncardiovascular parameters, EMG (frontal muscle), skin conductance reactivity, and respiration. NC-Type A and Type B women did not differ in performance, but the Type As showed stronger vasoconstrictive responses to the task than did the Type Bs. Other physiological intergroup differences were not seen. In addition, the Type As scored significantly higher in nervousness and irritability and marginally higher in depression, reactive aggressivity and neuroticism than did the Type Bs. This particular pattern of NC-Type A/B differences is discussed with regard to relevant differences observed by other studies between SI and JAS Type As and Bs.     

Enhancement of fibronectin expression by herbimycin A

Summary Herbimycin A specifically inrreased the level of fibronectin mRNA in Rous sarcoma virus-infected rat kidney cells, and the time course of fibronectin expression was found to be closely related to that of morphological change induced by herbimycin A.Acknowledgments. The authors wish to thank Dr Y. Uehara, National Institute of Health, Tokyo, and Dr K. Hayashi, National Cancer Center Research Institute, Tokyo, for valuable suggestions. This work was supported in part by grants from the Ministry of Education, Science and Culture and the Ministry of Health and Welfare of Japan.     

Tumor necrosis factor-α inhibits collagen synthesis in human and rat granulation tissue fibroblasts

The purpose of the study was to examine the effects of tumor necrosis factor- (TNF-) on collagen gene expression in rat and human granulation tissue fibroblast cultures. The cells were exposed to 0.1, 1, 10, or 100 ng/ml of TNF-, and the rate of collagen synthesis was measured as synthesis of protein-bound³H-hydroxyproline. Total cellular RNA was isolated from fibroblasts, and measurements of specific cellular RNAs from fibroblasts were performed by Northern blot hybridizations using³²P-labeled cDNA probes. In cultures of rat granulation tissue fibroblasts TNF- decreased³H-hydroxyproline production to about 75% of that in controls and it also decreased pro1(I) and pro1(III) collagen mRNA levels, maximally to 33% and 23% of the control levels, respectively. In cultures of human granulation tissue fibroblasts a similar inhibiting effect in the production of collagen was seen. TNF- decreased the production of³H-hydroxyproline to 56% of the control value with a dose of 100 ng/ml also having an inhibiting effect on pro1(I) collagen mRNA levels of up to 43% of the control level. However, no effect was seen on pro1(III) collagen mRNA levels.     

Enzymatic formation of potential anticancer and antiviral inosine analogues

Theoretically, inosine analogues should act as effective inhibitors of tumor cell proliferation and viral replication. To acquire a broad spectrum of new candidate inosine analogues, a rapid, facile, quantitative and stereoselective method for deaminating potential antitumor and antiviral adenine analogues previously synthesized in our laboratory was developed. A novel 5-adenylic acid deaminase, with relaxed substrate requirements, fromAspergillus species was utilized to deaminate four hexofuranosyladenine nucleosides and five adenine nucleoside dialdehydes to their corresponding inosine analogues. The fastest rates of deamination for the hexofuranosyl nucleosides were for the compounds where the vicinal hydroxyl groups on the sugars are oriented in the erythro configuration. For rapid deamination of the adenine nucleoside dialdehydes, theR configuration at the proximal carbon atom is preferred, while the nature of the group on the distal carbon atom has no significant effect on the rate or extent of deamination.     

基于机器视觉的指针式仪表检测

本文提出了一种基于机器视觉的变电站指针式仪表检测算法。该算法基于YOLO v3神经网络,引入Res2Net残差模块以及采用特征层融合的方式,采用更少的模块和网络层数获取更高的特征提取效率,通过增加SPP（空间池化金字塔,Spatial Pyramid Pooling）模块融合多重感受野,使用GIoU（Generalized Intersection over Union）损失函数代替原有的损失函数。此外,针对数据集的不同,采取k-means++聚类算法重新选择锚点框的尺寸。实验结果证明,在保证精度的前提下,相对于Faster R-CNN和原始的YOLO v3网络,速度分别提升了73.7%和45.8%。     

波浪在圆弧型浮式多孔介质防波堤绕射的解析

为研究圆弧型浮式多孔介质防波堤的防浪效果,给出了圆弧型浮式多孔介质防波堤对波浪绕射计算的解析方法。假定防波堤刚性垂直薄壁、空间固定、水深恒定。假想存在一个圆柱面,把流场划分为内外区域,在每个区域上将速度势用特征函数展开,然后在它们的公共边界上进行匹配。匹配的原则是公共边界上速度连续、压力连续,从而可得到关于未知系数的一组线性代数方程组,解出未知系数,即可求得流域中任意一点的速度势和波高。数值结果给出了不同入射波波长及防波堤不同垂向沉深和不同孔隙率时防波堤周围波幅的等高线图。结果表明,圆弧型浮式多孔介质防波堤的防浪效果与入射波波长和防波堤的垂向沉深及孔隙率密切相关。     

环Z_4+vZ_4上的斜循环码

文章研究了环Z4+vZ4上的斜循环码,其中v2=v,利用斜多项式环R[x;θ]的结构性质给出了斜循环码的生成多项式,并讨论了环Z4+vZ4上的斜循环码与循环码和准循环码的关系;确定了在欧几里得内积和厄米特内积下环Z4+vZ4上偶长度的斜循环码的对偶码的生成多项式。     

基于线谱对高效矢量量化的0.6 kb/s语音编码算法

为了提高通信系统的抗干扰和抗攻击能力,尽可能降低语音编码速率.提出了一种O.6 kb/s语音编码算法.算法基于3帧联合,对多帧联合参数采用高效矢量量化,在降低语音编码速率的条件下保证语音编码质量.其中,对线谱对参数采用预测多模式多级矢量量化码本结构.在码本设计过程中,提出了多模式渐进闭环设计,对各类码本联合优化,并联合优化预测器和量化器,可以有效提高线谱对参数量化质量.在译码方,采用多带混和谐波激励提高合成语音清晰度.测试结果表明,该语音编码算法合成语音PESQ(perceptualevaluation of speech quality)得分可以达到2.7,汉语诊断押韵测试DRT(diagnostic rhyme test)得分可以达到89.7.