Butyrate-induced reactivation of the fetal globin genes: A molecular treatment for theβ-hemoglobinophaties

The inherited -hemoglobinopathies (sickle cell disease and thalassemia) are the result of a mutation in the adult () globin gene. The fetal globin chain, encoded by the globin genes, can substitute for the mutated or defective globin chain, but expression of the globin gene is developmentally inactivated prior to birth. Reinducing expression of the normal fetal globin genes is a preferred method of ameliorating sickle cell disease and the thalassemias. Stimulation of as little as 4–8% fetal globin synthesis in the bone marrow can produce >20% fetal hemoglobin in the peripheral circulation, due to enhanced survival of red blood cells containing both sickle and fetal hemoglobin, compared to those containing sickle hemoglobin alone. Butyric acid and butyrate derivatives are generally safe compounds which induce fetal hemoglobin production by stimulating the promoter of the fetal globin genes. An initial trial with the parent compound, delivered as Arginine Butyrate, has demonstrated rapid stimulation of fetal globin expression to levels that have been shown to ameliorate these conditions. Phase 1 trials of an oral butyrate derivative with a long plasma half-life have just begun. These agents now provide a specific new apporach for ameliorating these classic molecular disorders and merit further investigation in larger patient populations.     

Tissue-specific induction of intestinal glutathione S-transferases by αβ-unsaturated carbonyl compounds

Summary Glutathione S-transferase activity in rat intestinal mucosa was increased by the injection of -unsaturated carbonyl compounds such as phorone and diethylmaleate, but that in the liver and kidney was not. Since the administration of cycloheximide completely blocked the increase of the enzyme activity by phorone, the increase of the activity may be due to de novo synthesis rather than enzyme activation.     

洛仑兹力公式中的速度V的含义

本文利用具体实例证明了洛仑兹力公式中的速度v是电荷相对于观察者的速度。     

受集中弯矩矩形板的位移和边界值

给出了由任一点集中弯矩引起的弯曲矩形板的位移公式和由该载荷引起的弯曲矩形板的边界值。最后给出了算例。     

焦化废水中几种含氮杂环化合物缺氧降解机理

对焦化废水 几种主要的含氮杂环有机物（吡啶,吲哚,喹啉,异喹啉,2－甲基喹啉）在缺氧条件下的降解试验研究结果表明,几种受试物质在缺氧条件下均可降解,其中吡啶的降解速度远大于其余四种物质,有机物定量结构－生物降解性关系（QSBR）研究表明缺氧条件下上述物质的反硝化速率常数与分子连接性指数1X之间有较好的相关性。     

反铁磁质的体静磁波

通过计算和分析得到在垂直磁晶磁矩的外磁场下反铁磁质的体静磁波的频率与波矢的大小无关,只取决于波矢的方向,以及静磁波的频率在外磁场大小变化的情况下取值变化的规律。     

关于Pelczynski性质(v)

:给出了Banach空间上每一个无条件算子成为完全连续算子或紧算子的充分必要条件 ,并且讨论了具有这种性质的Banach空间的结构     

ILASⅡ v2.0读者定长数据批录入的具体方法

探讨了ILASⅡv2.0系统定长数据接收模块提供的读者定长数据批录入功能的使用方式,阐述了将Excel格式数据转换成ILASⅡ可以接收的数据格式的方法,并将读者信息批量导入系统数据库。其步骤为:确定读者数据格式、制作读者数据源文件Excel表格、转换ILASⅡ数据格式、备份ILASII数据库、ILASII数据导入、照片批量导入。     

CD44v6和p16在宫颈上皮内瘤变及宫颈癌中的表达及意义

目的探讨CD44v6和p16表达产物在宫颈上皮瘤样病变及宫颈癌中表达的意义。方法对正常宫颈鳞状上皮、宫颈上皮内瘤变（CIN）和宫颈癌组织共95例,采用免疫组织化学SP法,对宫颈癌变过程中CD44v6和p16蛋白进行研究,将结果进行统计分析。结果CD44v6蛋白在CIN中的表述高于正常宫颈上皮（P〈0.01）,在宫颈癌中的表达也高于正常宫颈上皮（P〈0.01）,且高于CIN中的表达（P〈0.01）,p16蛋白在CIN中的表达高于正常宫颈上皮（P〈0.01）,在宫颈癌中的表达也高于正常宫颈上皮（P〈0.01）;CD44v6和p16两种蛋白在CIN和宫颈癌中的表达无明显差异。结论CD44v6和p16蛋白的表达与宫颈癌的发生有关,提示这两种蛋白有可能作为高危人群早期筛查的一种免疫组化指标。     

奇异值分解与神经网络结合的卫星云图云团移动预测

云团运动和发展演变的预测是暴雨等灾害性天气监测预报的重点和难点问题,针对当前云团预测中缺乏有效的非线性、非平稳预测手段,提出了奇异值分解SVD(singular value decomposition)与径向基网络相结合的云团预测途径.首先用SVD对云图进行分解,提取主要的云团结构特征,然后用提取出的云图奇异特征值和左右奇异向量作为模式识别因子,选择特定区域和季节的云图时滞序列采样,并用前后时段样本云图的奇异值和奇异矢量作为云图预测模型的输入、输出,通过对径向基网络的学习训练和误差迭代收敛,建立了云团运动的非线性预测模型.试验结果表明,该方法能合理地描述云团运动的基本特征和演变趋势.