高温直流超导量子干涉器心磁图仪的研制

研制了用于心磁测量的直流高温量子干涉器,并建立了单通道高温直流超导量子干涉器心磁图仪. 根据临床诊断标准,在磁屏蔽室内依次调节无磁床的位置,采集了人体胸前平面5×5正方格子上各点的心磁数据. 实验结果表明,健康人与心脏病患者的心脏磁场信号存在明显差异. 利用该系统,可为心脏病的临床诊断提供有价值的实验数据.     

七号信令集中监测系统的数据管理系统

七号信令网是电信网的重要组成部分,其运行质量直接影响到电信网及其各种业务的运行稳定性和实际效益。在集中监测系统框架的基础上,提出了在系统中建立多个数据库和数据仓库相结合的方案进行数据管理,并对数据管理系统的组成结构、逻辑结构、数据存储与应用做了进一步的研究。     

一种改进的混合预测冗余CORDIC算法

CORDIC作为一种计算三角函数的向量旋转的迭代算法,其硬件结构简单,易于并行化处理和VLSI实现,因而在实时信号处理方面有广泛的应用前景。本文提出了一种改进的混合预测CORDIC算法。该算法利用混合预测方法的设计思想,讨论了在具体数据格式下,混合角度集中间值的确定,并给出了算法的实现结构。由分析结果证明此算法具有高运算速度与低资源的优势,在结构上较传统冗余CORDIC算法节省近60%的冗余符号判别运算。     

Design of a CMOS Adaptive Charge Pump with Dynamic Current Matching

A novel structure for a charge pump circuit is proposed, in which the charge-pump （CP） current can adaptively regulated according to phase-locked loops （PLL） frequency synthesis demand. The current follow technology is used to make perfect current matching characteristics, and the two differential inverters are implanted to increase the speed of charge pump and decrease output spur due to theory of low voltage difference signal. Simulation results, with 1st silicon 0. 25μm 2. 5 V complementary metal-oxide-semiconductor （CMOS） mixed-signal process, show the good current matching characteristics regardless of the charge pump output voltages.     

用于语音识别的鲁棒自适应麦克风阵列算法

对现实环境中存在的混响以及非平稳干扰语音信源等因素导致的算法性能下降,提出了一种用于语音识别的鲁棒旁瓣对消算法。讨论了旁瓣对消算法在自适应麦克风阵列中的应用,分析了算法在不同的混响条件下、不同的干扰源的噪声抑制能力。该算法通过分帧处理将输入信号划分为一系列短时平稳的信号片段。根据当前帧的信噪比决定自适应滤波器的权系数更新方式。采用一定的范数约束来限制自适应滤波器权系数的误调整。实验结果表明该麦克风阵列在混响的现实环境中能够有效抑制平稳噪声源和交叠谈话背景干扰,提高了语音识别器的抗噪性能。     

带有频谱补偿的基频修改算法

针对当前多数在基于拼接的语音合成系统中使用的基频修改算法缺少对频谱进行补偿的情况,提出了一种带有频谱补偿的基频修改算法.在传统基音同步叠加(PSOLA)算法的基础上,以共振峰参数和频谱倾斜参数描述频谱特性,通过对频谱参数进行预测及修改,在修改基频的同时,有效地补偿了频谱特性.频谱参数的预测公式由各基频下的条件概率密度函数导出,频谱参数的修改通过正弦模型实现.实验表明,对于不同的汉语元音、基频修改因子和听者,在平均86.25%的情况下,该算法较传统PSOLA算法能够获得更接近自然音质的语音.     

Oxygen intervention in the regulation of gene expression: the photosynthetic bacterial paradigm

The means by which oxygen intervenes in gene expression has been examined in considerable detail in the metabolically versatile bacterium Rhodobacter sphaeroides. Three regulatory systems are now known in this organism, which are used singly and in combination to modulate genes in response to changing oxygen availability. The outcome of these regulatory events is that the molecular machinery is present for the cell to obtain energy by means that are best suited to prevailing conditions, while at the same time maintaining cellular redox balance. Here, we explore the dangers associated with molecular oxygen relative to the various metabolisms used by R. sphaeroides, and then present the most recent findings regarding the features and operation of each of the three regulatory systems which collectively mediate oxygen control in this organism.Received 26 June 2003; received after revision 30 July 2003; accepted 8 August 2003     

Angiogenesis and signal transduction in endothelial cells

Endothelial cells receive multiple information from their environment that eventually leads them to progress along all the stages of the process of formation of new vessels. Angiogenic signals promote endothelial cell proliferation, increased resistance to apoptosis, changes in proteolytic balance, cytoskeletal reorganization, migration and, finally, differentiation and formation of a new vascular lumen. We aim to review herein the main signaling cascades that become activated in angiogenic endothelial cells as well as the opportunities of modulating angiogenesis through pharmacological interference with these signaling mechanisms. We will deal mainly with the mitogen-activated protein kinases pathway, which is very important in the transduction of proliferation signals; the phosphatidylinositol-3-kinase/protein kinase B signaling system, particularly essential for the survival of the angiogenic endothelium; the small GTPases involved in cytoskeletal reorganization and migration; and the kinases associated to focal adhesions which contribute to integrate the pathways from the two main sources of angiogenic signals, i.e. growth factors and the extracellular matrix.Received 13 February 2004; received after revision 25 March 2004; accepted 19 April 2004     

一种适用于软件雷达系统的数据流驱动机制

针对雷达信号处理各功能模块之间显著的流水性特征 ,结合一个通用的雷达信号处理系统———由清华大学研制的通用高速实时雷达信号处理系统的实验样机DSM(dataflow ,sharedmemoryandmultiplebusinterconnec tion) ,在研究现有静态、动态数据流驱动机制特点的基础上 ,提出了一种新型的适用于软件雷达系统的进程间准动态数据流驱动机制 ,并针对一个雷达信号处理的范例程序说明了编译器数据流驱动表的生成和系统数据流驱动的过程。