Suitability of urethane anesthesia for physiopharmacological investigations in various systems Part 1: General considerations

Summary The suitability of urethane anesthesia for physiopharmacological investigations is reviewed. Total dose administered and route of administration are recognized as factors having a great influence on both resting parameters and biological responses to drugs. A peculiar characteristic of urethane is represented by its ability to induce a surgical plane of anesthesia without affecting neurotransmission in various subcortical areas and the peripheral nervous system. This makes urethane a suitable general anesthetic for studying neural function in both central and peripheral nervous systems and accounts for the preservation of a number of reflex responses in urethane-anesthetized animals.     

宗教文化对泉州古城街道活力的影响分析

以泉州古城为例,利用多源数据构建街道活力与其影响因素的分析框架,建立包含街道物理环境影响因素和宗教文化影响因素的街道活力评价指标体系.分析宗教建筑对街道活力的影响,并进一步分析宗教建筑与街道的空间关系对街道活力的影响.研究结果表明：街道活力与街道两侧的寺庙宗祠的数量呈负相关,香火旺盛的寺庙宗祠会提升附近街道的活力,但与寺庙宗祠距离无显著相关关系;在寺庙宗祠入口设置广场或宽敞的步行区可以集聚人气,并在寺庙宗祠周围布置商业或与其他景点结合以形成连续的活力点,有助于提升街道活力.     

飞机主动式余度作动舵面铰链力矩飞行测量方法

现代飞机舵面大多采用主动式余度作动系统。这种系统固有的力纷争现象,导致传统的基于原位载荷校准试验的飞机结构载荷测量方法,不再适用于现代飞机操纵舵面铰链力矩飞行测量。提出了一种基于离位载荷校准试验和原位载荷验证试验的飞机舵面铰链力矩测量方法,建立了相应的载荷测量模型,分析确定了铰链力矩测量精准度的影响因素,给出了可能引起的系统误差的验证和修正方法,形成了主动式余度作动舵面铰链力矩飞行测量流程。通过多型飞机舵面铰链力矩测量试飞,验证了该方法的可行性和有效性;提高了飞机舵面铰链力矩测量的精准度,为飞机舵面设计载荷验证与优化提供了可靠的实测载荷;得到了飞机舵面各作动机构的载荷分配,实现了飞机舵面作动系统力纷争的飞行监测,确保了飞行安全。     

地方高校高等数学课程学习成绩影响因素的统计分析——以滁州学院为例

为了进一步改善高等数学课程的教学效果,提高学生的数学素养,以地方应用型高校滁州学院为例,2018—2021年连续4年从学生、教师和学校3个维度基于高等数学课程的学习效果开展问卷调查;基于收集的样本数据,围绕学生学习的内生动力、外部因素、学校管理等多个维度,运用因子分析和线性回归分析方法,对学生学习高等数学课程成绩的影响因素进行统计分析,探索出了提高大学生高等数学课程学习成绩的有效方案。这为地方高校提高高等数学课程教学效果提供了一种途径和方法,可为相关的教学改革研究提供参考。     

棉花三系配套的研究

利用棉花杂种优势,是提高产量和改进纤维品质的有效途径。推广杂种棉的关键措施是进行三系配套,实行不育化制种。我们于1985年以哈型雄性不育材料为不育“源”,以北疆推广品种“新陆早一号”和“66—241”为回交亲本,进行回交转育。经过三年的回交和定向选择,现已基本育成不育性稳定的,农艺性状接近回交亲本的四个新的雄性不育系。1987年,开始了恢复系的转育工作,并取得一定的研究结果。同时对不育系的自然授粉也进行了初步的研究,发现不育系对野蜂有某种吸引力,因而有较高的单株成铃数;这对制种工作是十分有利的。     

The in vivo expression of the globin genes of theβ cistron in γ-,δ-, andδβ-thalassemia heterozygotes

There is considerable evidence suggesting that the switch from to and chain production after birth is due, in part, to silencing of the genes by stage-specific factors which bind to their promoters and to the competition from the adult ( and ) genes for a common enhancer element located in the locus control region. As a consequence one can expect that the increased Hb F production in adults with hereditary persistence of fetal hemoglobin or -thalassemia is directed mainly by -globin genes in cis to the deletion(s) responsible for these conditions. Here we review data on heterozygotes with -, -, or -thalassemia, who also had an^AT mutation, in cis or in trans, which was used as a marker of gene expression. The results show that a deletion affecting adult genes favors the expression of genes in cis, while the deletion of a single gene does not affect the expression of the gene in cis but leads to a faster switch postnatally.     

Detection of toxic metabolites in the hemolymph ofBeauveria bassiana infectedSpodoptera exigua larvae

Highly active metabolites have been detected in the hemolymph of the lepidopteranSpodoptera exigua infected with the mycopathogen,Beauveria bassiana. A combination of phenyl sepharose and CM ion exchange chromatography was utilized to extract the active metabolites from infected hemolymph samples. The active in vivo metabolites, having a molecular mass greater than 10 KDa, were thermolabile and were inactivated by proteinase K. These metabolites were characterized by their ability to disrupt metamorphosis, killing treated larvae at the wandering or pupal stage. Additionally, injection ofS. exigua larvae with active samples caused a reduction in the number of filopodial-producing hemocytes. The biological activities and biochemical properties suggest that novel compounds are produced duringB. bassiana mycosis.     

普通物理课程与“现代化”教学之探索

本文就大学普通物理课程与现代化的两个主要矛盾:学时与内容,内容与现代化,结合教学加以探索。     

车前的离体培养和植株再生

报道了国丧外植体的愈伤组织诱导及其植株再生的研究结果,单独的外源生长素２,４－Ｄ适宜诱导外植体脱分化产生愈伤组织。再生芽的分化只需添加６－ＢＡ;当ＮＡＡ与６－ＢＡ配合添加于培养基中时,则有利于再生根的繁茂生长,从而形成完整的再生植株。     

秦淮河流域典型排涝泵站前池水质与降雨特征响应关系

为分析排涝泵站前池水质与降雨特征的响应关系,对南京市城区秦淮河沿线2个排涝泵站前池水质以及降水量开展高频在线自动监测,结合回归树方法分析了不同降雨强度、前期干旱时间条件下排涝泵站前池水质变化规律,探讨了不同类型排涝泵站前池水质的主要影响因素。结果表明:晴雨天均有生活污水汇入的A泵站前池氨氮质量浓度在大雨强下降低,中雨强下先升高后降低,小雨强下平缓上升,A泵站前池污染物质量浓度主要受降雨强度和次降水量影响;主要接收降雨径流,雨量大时有生活污水溢流汇入的B泵站,前池污染物质量浓度在大雨强下先升高后逐渐降低,中雨强下降低,小雨强下变化不大,B泵站前池水质主要受次降水量、前期干旱时间和降雨强度影响;2个泵站前池CODMn质量浓度变化与降雨的响应规律相似,但更多受到与前期干旱时间关联的地表径流冲刷作用影响;连续降雨均导致泵站前池氨氮质量浓度和CODMn质量浓度波动变化较大,而前期干旱时间越长,降雨发生后泵站前池水质越差。