一种早期诊断皮下肿瘤的新方法

提出了一种采用微带六端口进行早期诊断皮下肿瘤的新方法 ,并研制了原理性的微带六端口皮下肿瘤早期诊断仪 .     

基于多级模糊法的高速公路隧道安全性评价（新修改）

根据某高速公路隧道的全面检测结果,尝试借助数学中的多级模糊综合评价方法,通过建立隧道结构构件安全状况与隧道整体结果评价之间的线性代换关系,对高速公路隧道安全性进行评价,工程应用实践表明,该评价方法以量化的形式给出评价结果,基本能客观反映隧道安全现状,可供同类工程项目借鉴参考.     

Neurotrophic regulation of synapse development and plasticity

Neurotrophic factors are traditionally thought to be secretory proteins that regulate long-tern survival and differe, ntiation of neurons. Recent studies have revealed a previously unexpected role for these factors in synaptie de velopment ami plasticity in diverse neuronal populations. Here we review experimeuts carried oul in our own laboratory in the last few years.. We have made two important discoveries.First,we were among the first to report that brain-derived. neurotrophie faclor (BDNF) facilitates hippocampal hmg-term potentiation (LTP), a form of synaptic plaslicity believed to be involved in learning and memory. BDNF modulates LTP al CAI synapses by enhaneing synaptic responses to high frequency, tetanic slimulalion. This is achieved primafily by facilitating synaptie vesicle doeking, possibly due to an in crease in the levels of the vesicle prolein synaptobrevin and synaptoplysin in the nerve terminals. Gene knockout study demonstrates thai the effects of BDNF are primarily mediated through presynaptic mechanisms. Second, we demonstrated a form of long-term, neurotrophin-mediated synaptic regulation. We showed that long-term treatment of the neuromuscu lar synapses with neurotrophin-3 (NT3) resulted in an enhancement of both spontaneous and evoked synaptic currcuts, as well as profound changes in thc number of synaptic varicosities and syuaptic vesicle proteins in motoneurons, all of which are indicative of more mature synapses. Our current work addresses the following issues:(i) activity-dependent trafficking of neurotrophin receptors, and its role in synapse-specific modulation; (ii) signal transduction mechanisms medialing the acute enhancement of synaplic transmission by neurotrophins; (iii) acute and long-tenn synaptie actions of the GDNF family; (iv) role of BDNF in late-phase LTP and in the development of hippocampal circuit.     

钢纤维混凝土在秦岭隧道衬砌中的应用研究

针对秦岭隧道工程的特点，提出了采用湿喷钢纤维混凝土作为隧道衬砌的方法．并从结构强度、变形能力和防水性能方面论证了此方法的优越性．最后给出了一个国外隧道工程的实例．     

岩溶隧道的围岩分级探讨

围岩分级是隧道建设的基础资料，对以铁路为主的隧道围岩分级历史作简要回顾。以大量的实践为基础，对勘察、设计、施工、运营各阶段的岩溶隧道问题进行了总结，对岩溶隧道的关键问题即岩溶围岩分级的可行性和必要性进行了分析，并探讨了今后的研究方向。     

张峰水库总干6号至12号隧洞工程地质评析

介绍了张峰水库总干工程概况，对张峰水库输水线路一千6号至12号隧洞围岩工程地质条件进行了分析与评价。     

浅析隧道坍方中水泥-水玻璃双液注浆施工工艺处理及应用

介绍了隧道坍方中水泥-水玻璃双液注浆施工工艺处理及其应用。     

采用钢轨棚架法处理隧道通顶塌方

本文介绍了处理隧道通顶塌方的一种施工方法——钢轨棚架法，该方法利用轻轨作为主棚架，对稳定山体及保证施工安全起到了至关重要的作用     

公路隧道交通疏散策略

针对公路隧道环境特殊、事故率高、救援困难的特点，合理地将隧道划分为若干个区域，设置相应的疏散引导信号；分析了在不同区域发生不同程度事故时的疏散路径、对应的信号状态，以及为避免横洞疏散车辆与主洞直行车辆发生冲突，确定开启疏散引导信号时间的计算公式；讨论了该公式中阈值的设定、数值的比较和利用比较结果确定疏散引导策略的方法；给出了公路隧道不同类型事故交通疏散的策略，并进行了模拟实验，结果表明控制与诱导效果良好。     

TBM掘进技术的发展与展望

比较了隧洞施工传统钻爆法及TBM法各自的特点,指出TBM法将成为长大隧洞施工的发展方向,介绍了TBM掘进技术的应用现状,并展望了其未来发展.