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101.
Jin Yan Cheng He Changlin Lu Chenghai Wang Xuan Bao Tieshan Tang Xiuying Huang Fangzhen Sun 《科学通报(英文版)》2001,46(6):477-480
The action of ciliary neurotrophic factor (CNTF) on intercellular free Ca2+ concentrations [Ca2+]i induced by glutamate (Glu) in primary cultured hippocampal neurons were detected with Fura2/AM, a Ca2+-sensitive fluorophore, and the morphological influence of G-protein on it was objected. Glu could induce rapid increase of [Ca2+]i in hippocampal neurons. CNTF had no significant action on [Ca2+]i in resting hippocampal neurons. However, after incubation of CNTF for 5 min, the increase of [Ca2+]i in hippocampal neurons rapidly induced by Glu was inhibited. Pretussis toxin (PTX)-sensitive G protein could block the action. These results indicate that a new non-genomic rapid sideway might exist in the upper stream of CNTF signal transduction pathway, which was related to Ca2+ signal transduction. Keywords: 相似文献
102.
对近年来视黄素受体介导视黄素抗癌作用机理的研究进展作一综述,主要有:1)视黄素受体;2)视黄素受体与细胞生长;3)视黄素受体与孤生受体的的相关性;4)视黄素受体对AP-1活性的抑制作用;5)视黄素受体介导的信号转导途径。通过研究,对于探讨视黄素受体的功能、阐明视黄素的抗癌机理、合成更多的受体选择性视黄素具有重要的现实意义。 相似文献
103.
鸟类离顶盖通路的结构和电生理特性 总被引:5,自引:0,他引:5
唐宗湘 《吉首大学学报(自然科学版)》2000,21(4):21-25
离顶盖通路是鸟类主要的视觉通路之一, 由视网膜、视顶盖、圆核和外纹体组成. 各结构之间具有区域性的对应投射;通路中的神经细胞具有不同的感受野特性, 对不同形式的刺激呈现出不同的反应模式. 参与物体运动方向和物体的朝向分析、运动物体的速度检测、颜色和物体轮廓处理、图象-背景识别、视觉指导定位、捕食和逃避反应等.离顶盖通路侧重于加工关于目标运动的特殊视觉信号,而对自身引起的视觉运动不敏感. 相似文献
104.
PPARγ配体的抗肿瘤作用 总被引:3,自引:1,他引:2
过氧化酶增殖体激活受体(PPARs)是一类核受体,PPARγ配体无论在体外还是在体内均可以抑制肿瘤细胞的生长,导致肿瘤细胞的凋亡并引起肿瘤细胞发生分化,并且PPARγ配体与维甲酸和非甾体类抗炎药联合应用可以加强其抗肿瘤作用.就PPARγ在肿瘤发生、发展中的作用,信号传导通路以及以PPARγ为靶点的药物研究进行分析。 相似文献
105.
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107.
Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible
for a wide variety of biological functions. Aldose reductase has been identified as the first enzyme involved in the polyol
pathway of glucose metabolism which converts glucose into sorbitol. Glucose over-utilization through the polyol pathway has
been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose
reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications.
Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to
explain the difference in the potency of enzyme inhibition. The aim of this review is to provide a comprehensive summary of
previous studies to aid the development of aldose reductase inhibitors that may have less toxicity problems than the currently
available ones.
Received 4 December 2006; received after revision 12 February 2007; accepted 20 April 2007 相似文献
108.
109.
Dreschers S Dumitru CA Adams C Gulbins E 《Cellular and molecular life sciences : CMLS》2007,64(2):181-191
Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen. 相似文献
110.
Huntington’s disease: from huntingtin function and dysfunction to therapeutic strategies 总被引:3,自引:0,他引:3
Borrell-Pagès M Zala D Humbert S Saudou F 《Cellular and molecular life sciences : CMLS》2006,63(22):2642-2660
Huntington’s disease (HD) is a neurodegenerative disorder that usually starts in middle age and is characterized by involuntary
movements (chorea), personality changes and dementia, leading to death within 10–20 years. The defective gene in HD contains
a trinucleotide CAG repeat expansion within its coding region that expresses a polyglutamine repeat in the protein huntingtin.
Together with the characteristic formation of aggregates in HD, aberrant protein interactions and several post-translational
modifications affect huntingtin during disease progression and lead to the dysfunction and death of selective neurons in the
brains of patients. The exact molecular mechanisms by which mutant huntingtin induces cell death are not completely understood
but may involve the gain of new toxic functions and the loss of the beneficial properties of huntingtin. This review focuses
on the cellular functions in which huntingtin is involved and how a better understanding of pathogenic pathways can lead to
new therapeutic approaches.
Received 24 May 2006; received after revision 5 July 2006; accepted 23 August 2006 相似文献