纸箱包装机连续高速纸板供给机构的设计探讨

纸板供给是高速纸箱包装机的瓶颈之一,为了满足80箱/min纸箱包装机的供板需求,提出垂直与水平相结合的解决方案。垂直输送技术比较成熟,实际应用比较普遍,为了提高水平输送速度,提出采用纸板水平短距离移动机构和对辊输送机构相配合的设计方案,对各部件工作原理及结构原理进行分析,论述设计的合理性和实用性,实现快速输送。     

面向快递业服务质量评估的组合评价方法研究

针对快递业发展现状以及在服务质量方面存在的问题,通过市场调研和数据分析,采用科学的分析方法,构建快递业服务质量评价指标体系。在该体系上应用层次分析法、民意调查法、专家定见法等获取各项的指标权重,对查询的快递企业用模糊综合评价法进行服务质量的分析评价,以获取快递型企业的服务满意度,以此提升整体服务绩效。     

基于坡面径流输沙模型的湘中红壤丘陵区土壤有机碳流失模拟研究

坡面径流是泥沙和土壤有机碳(soil organic carbon,SOC)流失的主要动力.本研究以典型湘中红壤丘陵区坡耕地(翻耕和免耕)为研究对象,通过野外径流小区模拟降雨试验,对已建立的以径流率为变量的对数线性回归坡面径流输沙模型进行修正,并结合泥沙中SOC的富集特性,建立湘中红壤丘陵区的坡面SOC流失模型.研究结果表明:坡面SOC流失模型能够有效地应用于湘中红壤丘陵区次降雨过程中坡面SOC流失的模拟中,且具有较好地模拟效果,SOC流失率模拟平均误差在30%左右,决定系数在0.85以上;同时模拟结果表明,泥沙和SOC流失过程在坡面径流侵蚀影响下呈现波动状态,表现为产流开始后10min泥沙和SOC流失呈增加趋势,其后在波动中逐渐趋于平稳;通过比较翻耕和免耕条件坡面径流输沙和SOC流失模型,结果显示侵蚀性降雨条件下,翻耕方式泥沙和SOC流失率大于免耕方式.非侵蚀性降雨条件下,翻耕方式泥沙和SOC流失状况与免耕方式一致.     

糖复合物的生物应用

糖类化合物是一类很重要的生物大分子,它在细胞膜表面通过形成各种复合物参与许多重要的生理活动。主要讨论了近几年糖类复合物在药物靶向传递及肿瘤成像/检测等方面的研究进展,综述了叶酸、寡糖等作为靶向基团的药物靶向传递体系,同时探讨了各种糖类复合物在细胞成像及生物检测方面的应用,指出了未来糖化学的发展前景。     

优先队列在物流配送管理中的应用研究

针对物流企业在配送管理业务流程中的要求与特点，提出了采用优先级队列来实现分拣配货的动态调度观点，并对涉及动态调度过程中的相关数据结构与算法进行了设计，采用此技术可以提高企业的经济与社会效益．     

带二维装箱约束的需求可拆分车辆路径问题模型及算法研究

车辆配送计划时通常会考虑货物易损、易碎的可能性,以及如何充分利用有限的运输资源对货物进行配送以满足顾客的需求。在车辆有限、货物易损坏、顾客需求可进行拆分等环境下,实现车辆配送总路径最短,即考虑二维装箱约束的客户需求可拆分的车辆路径问题。对问题进行详细定义,建立了2L-SDVRP模型。将遗传算法与BLF算法的结合求解模型;并用数值案例验证算法有效性。     

Preparation and cellular uptake of PLGA particles loaded with lamivudine

Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with lamivudine and coated with bovine serum albumin (BSA) were prepared via a double emulsion method. The influences of experiments parameters such as volume of inner aqueous phase, concentration of organic phase and ultrasonication time on the particle size and drug entrapment efficiency were investigated, obtaining PLGA particles with a diameter of ~260 nm and drug entrapment efficiency of ~35%. The particles were observed by scanning electron microscopy and transmittance electron microscopy, showing a core-shell structure. BCA assay found that 58 mg BSA was present on/in 1 g LPB particles. The loaded lamivudine showed a burst release at beginning and sustained release until 24 h in physiological conditions. Low pH could accelerate the release of lamivudine from PLGA particles, making the PLGA particles potential intelligent intracellular drug carriers. The PLGA particles were readily internalized into the human liver cells within a short time and increased gradually with the prolongation of incubation time regardless of the loading of lamivudine. The particles either resided within lysosomes or transferred to cytoplasm, but could not enter into the cell nucleus. The cell viability was not significantly influenced in the presence of the particles regardless of lamivudine encapsulation, suggesting that this kind of particles may be a good candidate for the intracellular anti-hepatitis B drug delivery.     

Enhancement of the efficiency of PEI/liposome transfection by magnetofectins formed via electrostatic self-assembly

One of the major challenges for successful gene therapy is improving the transfection efficiency of non-viral vectors. Magnetic nanoparticles (MNPs) have been developed as enhancers of non-viral vehicles. We prepared MNPs and modified them with polyethyleneimine (PEI), citric acid (CA) or carboxylmethyl-dextran (CMD). Both positively charged MNPs (MNPs@PEI) and negatively charged MNPs (MNPs@CA, MNPs@CMD) could spontaneously form transfection complexes (magnetofectins) with plasmid DNA and PEI/liposome via electrostatic self-assembly. Our results showed as-prepared magnetofectins apparently enhanced PEI/liposome transfection efficiency and/or gene expression level into COS-7 cells with reduced transfection time from 4 h to 15 min under a magnetic field in vitro. Meanwhile, the effect of magnetofection was cell line-dependant. These results suggest that charged MNPs could improve transfection efficiency for non-viral vectors by simply mixing with them and by exerting a magnetic force. Thus such MNPs provide a convenient platform for further applications of gene delivery.     

固载蛋白类药物的壳聚糖基管式膜的制备及体外缓释性能研究

以壳聚糖为载体,牛血清白蛋白(BSA)为模型药物,配制一定浓度的壳聚糖/药物溶液,将该溶液涂渍在硅胶导尿管表面,成功制备了壳聚糖基管式膜材料.考察了不同pH条件下该材料对蛋白类药物的缓释性能,并初步探讨了缓释机理.结果表明,固载蛋白类药物的壳聚糖膜材料在三种不同pH介质中对BSA均有明显的缓释作用,且在中性介质中效果最好,缓释时间超过36h,BSA缓释总量达6.0mg.该载体生物相容性好,对缓解病人术后因导尿管留置引发的尿路感染及其它副作用具有潜在的应用前景.     

受约束悬臂输流管振动的最优控制

使用压电片作为控制执行元件,对具有线性弹簧支承和三次非线性运动约束的悬臂输流管道的振动进行了最优控制·考虑压电片通上电流而产生伸缩后对管道施加的控制力矩,推导出了受控输流管系统的运动微分方程,并利用Galerkin方法对其进行了离散化处理·根据可同时使管道振动变形和控制输入能量达到最小的最优控制原则设计出了最优控制器,同时还对管道受控前后的运动响应进行了数值仿真,以验证该控制方案的有效性·通过比较发现,提出的最优控制方案不但能控制输流管的周期运动,而且对该系统的混沌运动也能进行有效控制·