试谈以学生为中心的化学教学设计

对以学生为中心的化学教学设计的内涵和特征作了初步的探讨，并分析盐类水解的化学程序启发教学设计，是如何充分体现了以学生为中心。     

建筑群与外部空间的整体意识：（Ⅰ）汽车站的总体设计

通过建筑外部空间理论的研究，提出建筑总体设计中的整体意识．以汽车站总体设计为例，阐述Ｎ空间的局部Ｐ化、锐角空间的钝化、不规则空间的几何化、化整为零等设计方法．     

组合夹具CAD中子组装模块参数化设计的研究

本文提出了组合夹具CAD子组装模块的概念,进行了参数化设计的探讨。文中重点叙述了参数化设计的方法及其优越性,并对设计中的具体问题,如夹具元件的确定,参数的输入、模块的生成等,做了深入的介绍。     

辽河油田L46块开发前期油藏工程研究

首先分析了辽河油田Ｌ４６块的地质特征，然后分析和介绍了开发前的油藏工程，主要包括前期准备井的部署原则，实施要求，指出该块必须采用注水补充能量的开发方式进行开发，给出了合理的井冈井距、即合理井距为３００ｍ，采用正方形并网，确定了油井产能为平均单井产油１０ｔ／ｄ，最后予测了年产原油６．６×１０４ｔ／ｄ，采油速度为２．２０％．     

绳状绞边装置的模糊优化设计

就绳状绞边装置的设计问题，根据模糊数学的基本理论提出了一种模糊优化设计方法，建立了该问题的模糊优化设计的数学模型，并对实例进行了计算与分析．     

羰基簇合物途径制备的碳载Pt-Co催化剂阴极抗甲醇性能

通过Pt和Co羰基簇合物途径制备了碳载Pt—Co(Pt-Co／C)复合催化剂．其金属粒子的平均粒径小．相对结晶度很低．与商业化的E-TEK Pt／C催化剂相比,该催化剂具有较好的抗甲醇性能和电催化氧还原活性．     

Transformation of the salt-tolerant gene of<Emphasis Type="Italic">Avicennia marina</Emphasis> into tobacco plants and cultivation of salt-tolerant lines

Salt-tolerant gene, CSRG1, which was isolated from a kind of salt-tolerant mangroves, Avicennia marina, constructed the transgenic plasmid, pGAM189/CSRG1. CSRG1, GUS, Kmr and Hyg^r could be transferred into tobacco genome by the ameliorated leaf discs method of agro-bacterium-mediate transformation. Thirteen stable resistant lines were obtained when fifty transgenic explants were selected through 50 mg/L hygromycin and 150 mg/L kanamycin. Assessments of PCR amplification, Southern blot analysis and GUS histochemical staining showed that CSRG1 has been integrated into the genome of the eleven transgenic lines (frequency of transformation was 22%). Northern bolt analysis revealed that CSRG1 had expressed in transgenic lines. The assessments of salt-tolerant ability and photosyn-thetic rates indicated that the survival rate of the transgenic lines is 80%—90% and the transgenic lines could increase by 30%—40% in plant height, even when they were cultivated in MS medium containing 2% NaCl and the total seawater (salinity 24). It is supposed that the special physiologic metabolic pathway formed by the products of CSRG1 can really endow the tobacco plants with the high salt-tolerant ability, not only to Na^ stress, but also to the comprehensive stress of various ions.     

Strategies for the design of inhibitors of aldose reductase, an enzyme showing pronounced induced-fit adaptations

Aldose reductase is involved in the polyol pathway, catalyzing the reduction of glucose to sorbitol. However, due to pronounced binding site adaptations, the enzyme can operate on a broad palette of structurally diverse substrates ranging from small aliphatic and aromatic aldehydes up to steroid-type ligands. A comparative analysis of the presently accessible crystal structures of aldose reductase complexes reveals four binding-competent protein conformations. Additional relevant conformers are detected through molecular dynamics simulations. They indicate an equilibrium of several conformers which is shifted towards the binding-competent geometries upon ligand binding. Such a manifold system with several alternative binding site conformers requires some tailored concepts in virtual screening. We followed two strategies, both successfully suggesting new micromolar inhibitors. In a first attempt, we concentrated on one preferred conformer and performed a virtual screening, assuming that the binding pocket of aldose reductase adopts only this conformation. In a second approach, we followed a ligand superpositioning method. Ligands were extracted in their bound conformations from three different crystal structures, all accommodating the ligands with different active site conformations. After merging these ligands into one supermolecule, mutual alignments were computed, taking candidate ligands from a screening database. The latter strategy also retrieved several structurally new inhibitors of micromolar potency.     

《服装结构设计》网络教学课件系统的研发

为适应服装专业远程教育的需要,针对《服装结构设计》课程,通过对多媒体教学系统的研究,利用网页设计工具,开发了基于Web的《服装结构设计》网络课件系统。     

对数凸度设计在十字万向传动轴中的应用

十字万向传动轴被广泛地应用在各类机械传动中,十字轴轴承是其重要的部件．轴承滚针的凸度设计,决定了滚动体与滚道间的接触压力分布,影响其性能和寿命．根据轴承结构对接触压力分布的影响,在滚针凸度设计时必须考虑滚针倒角半径和越程槽宽度的因素,并应用相应的数值计算方法．结果表明,使用这种方法设计的滚针轴承,其接触压力分布不会出现“边缘效应”,也不会在接触的中心部分出现应力集中。