缩氨基硫脲过渡金属配合物及其抗癌活性

合成并表征了苯甲醛缩氨基硫脲（ＨＬ）和３－硝基苯甲醛缩氨在硫脲（ＨＸ）与Ｃｕ,Ｃｏ,Ｚｎ,Ｍｎ的６个配合物,用体外试管法测试了配体和配合物的抗癌活性,结果表明,配体ＨＬ和ＨＸ是通过亚氨基Ｎ原子和Ｓ原子与过渡金属离子形成配合物,这些配合物的抗癌活性均强于配体,Ｚｎ（Ⅱ）和Ｃｕ（Ⅱ）配合物对腹水癌细胞的杀死率均为１００％。     

Variable Structure Control of Multi Delay Linear Systems

ＶａｒｉａｂｌｅＳｔｒｕｃｔｕｒｅＣｏｎｔｒｏｌｏｆＭｕｌｔｉ┐ＤｅｌａｙＬｉｎｅａｒＳｙｓｔｅｍｓ⒇ＤＥＮＧＦｅｉｑｉＦＥＮＧＺｈａｏｓｈｕＬＩＵＹｏｎｇｑｉｎｇＤｅｐａｒｔｍｅｎｔｏｆＡｕｔｏｍａｔｉｃＣｏｎｔｒｏｌＥｎｇｉｎｅｅｒｉｎｇ,Ｓｏｕ...     

Identifying the conformational state of bi-liganded haemoglobin

While most researchers agree on the global features of cooperative ligand binding to haemoglobin (Hb), the internal mechanisms remain open to debate. This is not due to inaccurate measurements, but is rather a consequence of the cooperative ligand binding that decreases the equilibrium populations of the partially liganded states and makes observation of the transitions between these substates more difficult. For example, the equilibrium population of the doubly liganded tetramers is typically less than 5% of the total Hb. As a result many models with widely varying mechanisms may fit the oxygen equilibrium curve, but may not be consistent with observations of other parameters, such as ligand-binding kinetics or subunit association equilibria. The wide range of methods and models has led to divergent conclusions about the properties of specific substates. One notable debate concerns the properties of the doubly liganded forms. The simple two-state model predicts a shift in the allosteric equilibrium based on the number of ligands bound, but not on their distribution within the tetramer. From studies of dimer-tetramer equilibria of various pure and hybrid forms, it was concluded that a tetramer with two ligands bound on the same α β dimer (species 21, an asymmetric hybrid) shows an enhanced tetramer stability, similar to singly liganded Hb, relative to the other three types of doubly liganded tetramers which resemble the triply liganded forms [Ackers et al. (1992), Science 255: 54–63]. The implications of this model and the relevant experiments will be reviewed here. Received 27 April 1998; received after revision 17 July 1998; accepted 10 August 1998     

煤炭工业结构优化的战略思考

以系统的观点探讨了我国煤炭工业结构优化的内涵及特征,论述了煤炭工业结构优化的必要性,进而提出了煤炭工业结构优化的目标及实现的主要措施。     

Pasternak 地基上自由边矩形板弯曲问题的 Fourier 级数解

应用正交函数系级数展开法分析结构的理论,以带附加补充项的Ｆｏｕｒｉｅｒ级数作为挠度函数模式,求解了Ｐａｓｔｅｒｎａｋ地基上自由边矩形板的弯曲问题。文中给出了算例。     

α-淀粉酶产生菌的平板筛选法的研究与改进

用平板水解圈法筛选到若干株 α 淀粉酶产生菌,它们的平板水解圈直径大小与摇瓶酶活不相关,进一步研究了３０ ℃平板淀粉的质量分数对水解圈直径的影响以及淀粉的质量分数、温度、琼脂等多种因素对离体 α 淀粉酶水解圈直径的影响,并在此基础上建立了一种快速筛选高产菌株的简便方法。     

TiAlN 保护膜的制备及结构研究

用反应磁控溅射方法制备了ＴｉＡｌＮ薄膜,结构分析表明,当Ｔｉ的含量小于０．２５时,ＴｉＡｌＮ薄膜是Ａｌ基氮化物的闪锌矿结构,但晶格常数随Ｔｉ原子含量的增加而增大．Ｘ射线光电子能谱分析表明,ＴｉＡｌＮ薄膜有与ＡｌＮ和ＴｉＮ不同的电子结构特征．     

钢闸门面板弹塑性极限承载力计算

试验表明钢闸门的面板在进入弹塑性阶段后,仍有很大的强度储备。根据板壳理论及结构塑性极限分析定理,分别推出了钢闸门面板的弹性极限承载力及塑性极限承载力,从而给出了钢闸门面板设计公式中的弹塑性调整系数的理论值,供修订规范参考。     

浅析立体构成在室内设计中的运用

立体构成是研究三度空间的三维形态,在遵循形式美原理的基础上创造出一定美感的、全新的三维形态的过程,而室内空间中大多数造型又表现为多种形式、形体的组合,这些形体正是由立体构成中的点、线、面、体的元素来共同创造的,在室内设计的过程中结合立体构成中的形式美法则,可创作出具有一定创新性的室内空间环境。