拓扑替康治疗卵巢癌的研究

拓扑替康(Topotecan,TPT)是新一代的半合成、水溶性的喜树碱衍生物.它是一种细胞核内DNA拓扑异构酶Ⅰ特异性抑制剂,化学名称为9-二甲基氨基10-羟基盐酸喜树碱.自合成以来已有大量临床报道显示TPT对卵巢癌有较好的疗效.现将TPT在治疗卵巢癌中的研究进展作一综述.     

产业集聚对经济增长的门槛效应分析

采用31个省市自治区2000—2017年的面板数据,以对外贸易为门限变量,运用面板门限模型探讨了产业集聚与经济增长之间的非线性关系.结果表明:产业集聚与经济增长之间的关系存在对外贸易门限效应,对外贸易门限值约为8.35％左右;从全国情况来看,当对外贸易水平处在低于门限值的区制时,产业集聚对经济增长的影响较大,而当对外贸...     

单模压缩奇偶相干态的四次方压缩特性

用单模压缩算子作用在单模奇偶相干态上即可得到单模压缩奇偶相干态.本文研究了这类量子态的四次方压缩特性,结果表明单模压缩奇偶相干态存在很强的四次方压缩特性,并且压缩程度随着压缩参量r的增大而增强.     

基于多产品或客户供应链订购聚集效应研究

对于供应链中多种产品或多个客户的订购策略,建立了3种订购策略的模型(单独订购策略、联合订购策略、搭载订购策略),并分别构建了3种订购策略的总成本函数.通过对3种订购策略聚集效应的分析,得出:搭载订购策略的聚集效应明显优于联合订购策略,而联合订购策略的聚集效应优于单独订购策略;当附加订购成本在总订购成本中占有较大的比重时,搭载订购策略可使总成本最小,其聚集效应明显;当附加订购成本在总订购成本中占有较小的比重时,则搭载订购策略变得不可行,联合订购策略会使总成本更小.     

邻近建筑对超高层建筑风振响应的干扰效应

在同济大学TJ-2边界层风洞中进行了上海环球金融中心气动弹性模型的风洞试验,分析了距离较远且高度约为环球金融中心一半的周边建筑以及距离较近且高度与环球金融中心相当的金茂大厦对环球金融中心顶部平动和转动平均位移、均方根位移和绝对最大加速度的干扰效应.结果表明:当高层密集建筑群(不考虑金茂大厦)集中在上游或上游偏一侧时,会对平均值和均方根有一定的影响,特别是扭转响应,当高层密集建筑群集中在下游时,影响很小;当金茂大厦位于环球金融中心的上游或上游稍偏一侧时,会减小环球金融中心的平动平均位移响应,表现为挡风效应,其尾流会增大环球金融中心的平动均方根位移响应,而当遮挡效应使得平均或脉动压力在形心轴两侧分布不均时会增大转动平均或均方根位移响应.与以往研究不同的是,当金茂大厦位于环球金融中心下游或下游偏一侧时,会改变环球金融中心的漩涡脱落频率,当漩涡脱落频率和结构第一阶固有频率接近时,会在该频率振动方向产生显著的涡激共振现象.当金茂大厦位于环球金融中心一侧时会产生狭道效应(穿堂风),可能会对水平和扭转的平均和均方根位移响应产生影响,视狭道方位和压力分布状况而定.     

The impact of temperature on the evolution and self-deflection of spatial optical solitons in photovoltaic photorefractive media

The temperature effects on the evolution and self-deflection of bright spatial optical solitons in photovoltaic photorefractive media were investigated by taking into account diffusion effects. The numerical results show that the evolution of the bright solitary beam depends strongly on the crystal temperature. It is also found that the bending distance of the bright solitary beam centre increases and reaches its maximum value at a characteristic temperature, and then decreases as temperature rises and approaches zero at low and high temperatures. Both the maximum value and characteristic temperature increase with the input power density. The self-deflection of bright solitary beam is further studied by a perturbation technique, and the results are found to be in good agreement with that obtained by the numerical method. The diffusion process and the dark irradiance dominate the temperature dependence of bending distance in most values of temperature besides at the characteristic temperature and in the higher temperature regime. The diffusion process will mainly dominate the temperature dependence at the characteristic temperature and the dark irradiance will dominate in the higher temperature range. Supported by the National Natural Science Foundation of China (Grant Nos. 10574051, 10174025), Natural Science Foundation of Hubei Province (Grant No. 2008CDB005) and Research Foundation for Outstanding Young Teachers, China University of Geosciences (Wuhan)     

A bionic artificial joint system and investigation of tribological performance

Joint replacement is one of the most common and successful operations in orthopaedic surgery. It consists of replacing painful, arthritic, worn or cancerous parts of the joint with artificial surfaces shaped in such a way as to allow joint movement. The polyethylene component has been implicated as the key factor affecting the lifetime of these prostheses. This paper introduces a bionic artificial joint system which aims to prolong the lifetime of such prostheses. Included are bionic system design, investigation of bionic therapeutic lubricants and analysis of the mechanical properties of hip prostheses. Possible future developments which might improve artificial joints are also discussed. Supported by the National Natural Science Foundation of China (Grant No. 50105014), Science and Technology Committee of Shanghai (Grant No. 04 QMX1442), Shanghai Leading Academic Discipline Project (Grant No. Y0102) and Graduate Innovation Fund of Shanghai University (Grant No. A.16-0109-07-002)     

平面和空间问题地基承载力理论公式的泊松比效应

结合弹性理论平面问题中均布条形荷载和空间问题中均布轴对称荷载作用下附加应力解,建立了计入不同泊松比值的地基承载力理论计算公式。利用数值结果讨论了平面和空间问题地基承载力公司的泊松比效应及涉及参数的工程意义。     

基于退化机理的混凝土桥梁耐久性环境区划

系统研究了桥梁耐久性设计的环境作用和区划.首先,从环境作用对混凝土桥梁的影响和导致的混凝土桥梁的耐久性病害出发找出不同区域混凝土桥梁耐久性退化的主要因素;其次,依托国家气象中心的气象资料对混凝土结构耐久性有显著影响的环境指标进行调查分析,获取代表城市的环境数据,对常规环境参数进行了调研;再次,借鉴现有的规范和标准,选择适当的区划参数对混凝土桥梁的工作环境进行了分类;最后,运用桌面地理信息系统软件ArcGIS绘制了全国耐久性环境区划图,得到了对应于不同环境参数的环境区划图表.     

脉冲电磁场对人血细胞膜的影响

红细胞经脉冲电磁场照射后,质膜耐低渗能力下降,最大脆性升高;电镜扫描发现人成熟红细胞变成球形;Ｔ淋巴细胞膜表面绵羊红细胞受到影响,导致淋巴细胞与绵羊红血细胞形成玫瑰花结的能力显著下降。