Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline

Summary The profile of action in animals of CQP 201-403, a novel 8-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel^®).In memory of Dr Annemarie Closse, who died 14 June 1987.     

也谈“用惠斯通电桥测电阻”实验

本文主要对杨介信、陈国英编写《普通物理实验(二、电磁学部分)》“用惠斯通电桥测电阻”实验中δR_(x0)=(R_4/R_3)δR_2的含意等五个问题,提出自己的不同看法。     

现代站立式背向滑步推铅球技术的探讨

站立式背向滑步推铅球,是近年来国内外田径大赛中出现的一项新技术。通过力学和解剖学两方面的分析,证明站立式技术具有节省体力、滑步速度快,动作加速连贯性强、有利于最后“鞭打”用力,兼有动作简单、容易掌握等特点,具有较高的实用和推广价值。     

纤维的形变和断裂——Ⅰ.拉伸角蛋白纤维形变和断裂的动态研究

作者在扫描电子显微镜样品室中拉伸角蛋白纤维,观察纤维形变和断裂的过程并摄取其照片。采用低加速电压观察和适当的样品准备技术,避免了纤维在拉伸过程中出现荷电现象。该现象是非导电材料作动态观察的主要困难。从所观察到的纤维形变和断裂形态和高聚物断裂理论讨论了角蛋白纤维的形变和断裂机理。结论如下:角蛋白纤维伸长和断裂过程中出现银纹样形态,但其断裂为脆性方式;该类纤维的拉伸断裂起始于角质细胞的内、外角质层;角质与角质和角质与皮质细胞间的物质是角蛋白纤维的力学薄弱区。     

飞机尾喷焰光辐射特性计算建模中的二个重要环节的改进

本文对使用谱带模型理论方法计算尾喷焰光辐射特性所出现的等价宽度问题进行了较为详细的讨论,研究了几种形式等价宽度的有效性,并提出了计算尾喷焰辐射的“穿截尾喷焰小气柱”方法,回避了四重积分的计算,得到了良好效果。     

有穷长半模偏序集上的一个定理

本文是对参考文献[1]第二章定理14证明的补充和改进。该定理乃指: 定理14.在任何上(或下)半模的有穷长的偏序集内,Jordan-Dedekind链条件成立。 文献[1]中,考虑上半模情形,谈到已知一个连接链:γ∶a=x_0相似文献   

Proopiomelanocortin expression in the skin during induced hair growth in mice

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti -endorphin in late but not early anagen or telogen skin. By immunocytochemistry, -endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.     

Purification of platelet-derived endothelial cell growth inhibitor and its characterization as transforming growth factor-β type 1

In 1986, Brown and Clemmons (Proc. natl Acad. Sci. USA83 (1986) 3321) showed that platelets contain a substance, platelet-derived growth inhibitor (PDGI), that inhibits in vitro endothelial cell replication. Although platelets are rich in transforming grwoth factor (TGF-), PDGI was considered not to be related to TGF-, on the basis of its reported properties (extraction from platelets at neutral pH, binding to heparin-Sepharose). However, we purified PDGI to near homogeneity and showed that on the basis of HPLC retention behavior, in vitro growth inhibitory activities with several cell types, receptor binding, and immunoneutralization of growth inhibitory activity with specific anti-TGF- type 1 antibodies, PDGI is most probably identical with TGF- type 1.     

Evaluation of the hepatotoxicological effects of a drug in an in vivo/in vitro model

Both in vivo and in vitro models have certain disadvantages for the study of the chronic hepatotoxicity of drugs. The aim of this work was to evaluate a new approach based on an in vivo/in vitro model. After chronic in vivo treatment of rats with Vincamine and Vindeburnol (an eburnamenine derivative which exhibits hepatotoxic properties in man) liver cells were isolated, and functional and metabolic disorders (metabolic utilization of fructose and protein biosynthesis) were studied to determine injury. The results showed no modification of blood parameters, but a direct relationship between the dose of Vindeburnol administered in vivo and the metabolic disorders observed in vitro, evidencing the high sensitivity and reliability of this model.