Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

"藏汇于国"到"藏汇于民"的外汇投资渠道探讨

为了更好地落实藏汇于民,必须拓展外汇投资渠道,使藏汇于民成为可能。文章主要探讨当前可能的主要外汇投资渠道,并就在外汇投资活动中需要注意的事项给予说明。     

利玛窦与西方数学的传播

利玛窦构建了良好的知识结构,具有很深的数学功底;他注意理论与实际的结合,学以致用,为他到中国传播西方的数学奠定了坚实的基础;他以数学赢取民心支持,在中国不仅传播了欧氏几何,而且还传播了大量非欧几何等数学知识;他一方面激活了正在走向衰落的中国传统数学,开创了中西数学文化融合的新纪元,另一方面他也激励了一大批中国数学家的成长、成才,推动了中国近现代数学的萌芽发展.     

论企业技术创新的评价

讨论了企业技术创新的评价方法，引入事实评价与价值评价标准，对企业技术创新进行技术评价和社会评价。认为只有当企业技术创新的技术评价和社会评价均为可行时，技术创新方案才原则上可以采用。     

丙酮缩二甲醇的合成及应用

介绍了丙酮缩二甲醇的合成方法及其主要用途,概要地报道了合成丙酮缩乙二醇及以此为原料合成丙酮缩二甲醇的新工艺。     

船舶二维图形交换研究

船舶图形在不同的CAD系统中交换，共享是现代船舶工业发展的需求，主要论述了如何在2个船用CAD软件（CADDS5和TRIBON M1）之间进行二维图形信息的交换。     

化工传热过程计算方法的分析

通过分析比较化工传热过程计算中的平均温度差法(MTD法)和传热单元数法(NTU法),找出了它们之间的内在联系,结合这两种方法的优点,组合成了一种新的计算方法,应用于化工传热过程的计算,可使计算过程大为简便,同时又可评价换热设备流动型式的合理性。     

The Frontier Movement and The American Values and Beliefs

This paper briefly accounts the background of American values and beliefs. It analyses the essence of the American ideals and points out that the American values are exaggerated and glamorized by the American upper class. They are in a sense, a dose of anaesthetic and a kind of hypocrisy.     

The Response of Debris-Flow Events to Solar Proton Flares （Ⅰ）

By analyzing the observation data from Dongchuan Debris Flow Observation and Research Station and historical data from year 1965 to 1990 gotten from National Astronomical Ob-servatories/Yunnan Observatory,the responding of debris flow in Jiangjia Ravine to Solar Proton Flare is studied. The following conclusion can be drawn. Solar Proton Flare,as one of most im-portant astronomical factors,affects the activity of debris flow in Yunnan. Generally,from 1965 to1990,the more active Solar Pro-ton Flare is,the greater the probability of high frequency and large runoff of debris flow is. On the contrary,the less active Solar Pro-ton Flare is,the greater the probability of low frequency,small runoff,and low sediment transport of debris flow is.     

强伪凸函数的某些性质

强伪凸函数是凸函数的重要推广函数之一。文中在给出强伪凸函数定义的基础上讨论了它的一些性质,另外还给出了它与强凸函数之间的关系。