Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension

Hypoxic pulmonary hypertension, an important pathophysiological process in the development of a vari-ety of clinical cardiac and pulmonary diseases, has critical influence on the proceeding and prognosis of the dis- eases[1]. It is important to clarify the pathogenesis of the diseases. The discoveries of endogenous gas signal mole-cules, nitric oxide (NO) and carbon monoxide (CO), have been moving the research of hypoxic pulmonary hyper-tension to a very new phase. Our foregoing experiments …     

高血压病的运动疗法

采用文献研究方法 ,对高血压病运动疗法的机制进行了研究分析 ,针对不同年龄组的高血压患者 ,制定了运动处方 ,同时提出每周 3次的中低强度运动可以取得更为理想的降压效果     

创造性人格特征的研究

采用献研究法和问卷调查法，对创造性人才的人格特征进行了剖析，提出了创造性人才普遍具备的人格特征，为探索创造性人才的培养途径及学校教育的培养模式提供了理论基础。     

洛汀新对原发性高血压左室肥厚并发室性心律失常影响研究

选择 8 6例原发性高血压的患者 ,按心脏超声心动图分为左室肥厚组 (A组 )和非左室肥厚组 (B组 )进行比较室性心律失常的发生率 ,并采用血管紧张素转换酶抑制剂洛汀新进行治疗观察 .结果表明 :A组室性心律失常发生率与B组有极显著性差异 (P <0 .0 0 1) ,而治疗前与治疗后室性心律失常的检出率及Lown’s分级危险性为显著性差异 (P <0 .0 1) .洛汀新具有较好的应用前景     

Increased Na+-H+ exchanger activity in the ileal brush-border membrane of spontaneously hypertensive rats

In the present study, we have examined the intestinal Na⁺ transport, through the Na⁺-H⁺ exchanger, in ileal brush-border membrane vesicles (BBMV) isolated from spontaneously hypertensive rats (SHR), and normotensive Wistar Kyoto (WKY) rats as a control group. Na⁺ uptake into ileal BBMV was stimulated in the presence of a proton gradient (pH 5.5 inside/pH 7.5 outside) in SHR and WKY rats, resulting in a transient accumulation (overshoot) in both groups of rats. No overshoot was observed in the absence of a pH gradient. The magnitude of the accumulation was significantly higher in SHR than in WKY rats. Uptake of Na⁺ at equilibrium was identical in the presence and the absence of a proton gradient and was not changed in SHR. The use of amiloride inhibited pH gradient-driven Na⁺ uptake in a dose-dependent manner with a Ki of 90 μM and 100 μM for SHR and WKY rats, respectively. The relationship between proton gradient-driven Na⁺ uptake and external Na⁺ concentration was saturable and conformed to Michaelis-Menten kinetics in both SHR and WKY rats. Lineweaver-Burk analysis of the pH gradient-driven Na⁺ uptake indicated values of V_max that were significantly increased in SHR compared to WKY rats (11.4±0.55 nmol/mg/8 s vs. 4.96±0.78 nmol/mg/8 s for SHR and WKY rats, respectively). In contrast, similar K_m values for Na⁺ were found between SHR and WKY rats (4.0±0.2 mM vs. 4.9±0.6 mM for SHR and WKY rats, respectively). These studies show derangement in ileal BBMV Na⁺ transport of SHR, which is characterized by increased Na⁺-H⁺ exchanger activity. Received 18 December 1996; received after revision 3 February 1997; accepted 7 February 1997     

非胆系疾患胆囊壁增厚的机理及临床意义——附22例报告

研究近期超声发现22例非胆系疾病的胆囊壁增厚,以探讨胆囊壁增厚的发病机理及临床意义。     

3598名本科大学生高血压普查及分析

对我校3598名18～22岁的本科大学生高血压调查,受检率91.42％,其中男2701人,女897人。结果高血压20例,患病率0.56％,男19例,女1例,发现男显著高于女。临界高血压51例,男患病率1.74％,女0.45％,男显著高于女,工科生2.04％,文科0.43％,工科学生极显著的高于文科。本文资材提示患病率高可能与学习比较紧张有关系,并说明了女性患高血压的年龄比男性晚。这次普查为本校大学生开展高血压防治工作有一定的实际意义。     

依那普利对高血压病患者左心功能及血浆心钠素水平的影响

采用放免法及多普勒超声测定３４例Ⅰ～Ⅱ期高血压病患者及２０例正常人血浆心钠素水平（ＰＡＮＦＣ）及左心功能，并给高血压病人Ｅｎａｌａｐｒｉｌ治疗２周，观测它对血浆心钠素水平和左心功能的影响。结果发现。高血压病人ＰＡＮＦＣ显著升高（Ｐ＜０．０５），左心功能受损害，Ｅｎａｌａｐｒｉｌ能明显降压，同时降低血浆心钠素水平，改善左心功能，增加心排血量     

老年高血压患者血清瘦素水平的临床研究

目的 :探讨老年高血压患者血清瘦素 (Leptin)水平变化及意义。方法 :采用放射免疫测定 41例老年高血压患者和 2 5例老年非高血压患者血清瘦素与正常人对照。结果 :老年高血压组血清瘦素明显高于正常对照组 (P <0 .0 1) ,也高于老年非高血压组 (P <0 .0 5 )。结论 :老年高血压患者血清瘦素较非高血压者高 ,提示血清瘦素与高血压有显著的相关性     

主动脉夹层合并重叠综合征1例临床分析

目的探讨主动脉夹层合并重叠综合征的诊治方法.方法总结患者病历报告,并结合查阅文献,以进一步明确重叠综合征是导致主动脉夹层的主要原因.结果重叠综合征是导致主动脉夹层的主要原因.结论重叠综合征在主动脉夹层的发病中起主导作用.