Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry （LC-MS/MS） assay for determination of risperidone （RIS） in human serum using paroxetine as an internal standard （IS）. An Alltima-C18 column （2.1 mm×100 mm, 3 μm） and a mobile phase consisting of 0.1% formic acid-acetonitrile （40：60, v/v） were used for separation. The analysis was performed by selected reaction monitoring （SRM） method, and the peak area of the m/z 411.3→191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25-50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%-9.09% and 1.56%-4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%-84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets （test versus reference products） in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent.     

高性能混凝土的强度影响因素的探讨

讨论了混凝土的骨料级配对混凝土强度的影响，认为优良的骨料级配可以配制出工作性较好、强度较高的高性能混凝土。通过混凝土受压试件的尺寸效应，讨论了高性能混凝土需重点解决的力学性能，探讨了混凝土坍落度与流动度的关系。     

PCM部分与全蓄冷空调系统的经济技术分析

对蓄冷材料为高温相变材料的部分与全蓄冷空调系统方案提出了经济技术分析的模型，并根据该模型对中国科技大学专家楼的蓄冷空调方案进行了计算．结果表明，部分蓄冷空调方案目前优于全蓄冷方案．该分析方法也适用于冰水蓄冷系统．     

通过GPIB接口实现数字存储示波器与微机之间通讯

利用ＧＰＩＢ接口总线实现微机与数字存储示波器ＰＭ３３５０数据传输。讨论了联机过程中有关问题，给出了控制程序的流程图。     

柔性的比较性定义和性质

对柔性问题的研究和实际运用面临的一个主要困难是可操作性．为解决柔性操作性问题，在给出柔性基本性质的基础上，提出了柔性的比较性定义，给出了该定义及其性质的数学描述，并结合一些模型解释了柔性定义及性质的应用．     

ATM交换的性能测试基准

为了响应１９９５年ＡＴＭ论坛关于开展测量基准研究的决定，本文提出了几个比较ＡＴＭ交换机性能的度规，并论述了几个与流量管理有关的度规．     

Data Location Mechanism in Agent-Based Autonomic Storage Systems

This paper introduces agent-based methodology to build a distributed autonomic storage system infrastructure, and an effectively negotiation mechanism based on agent is applied for data location. We present Availability-based Data Allocation （ADA） algorithm as a data placement strategy to achieve high efficient utilization of storage resources by employing multiple distributed storage resources. We use Bloom filter in each storage device to track the location of data. We present the data lookup strategy that small size of read request is handled directly, and large size of read request is handled by cooperation with storage devices.The performance evaluation shows that the data location mechanism is high available and can work well for heterogeneous autonomic storage systems.     

钢结构焊接缺陷及角焊缝超标浅析

论述了钢结构焊接缺陷的几种类型,分析了钢结构的焊缝缺陷对结构构件性能及变形的影响。     

关于高校教师绩效评价问题的软思考

提出了采用软系统方法论的调查学习范式研究高校教师绩效评价问题的观点,针对高校教师绩效评价问题的不良结构系统特性,分析了高校教师劳动的特殊性以及表现出来的价值观冲突,采用根定义的方法构建了高校教师绩效评价体系模型。     

检察院业务、办公计算机网络管理信息系统

介绍了检察院各部门工作的特点和工作流程.阐述了检察院工作管理和信息处理自动化的必要性,并且较详细的给出了系统的设计方案.