Silk Fibroin Microspheres： Preparation and Application for Controlled Drug Delivery

Silk fibroin （SF）, a natural protein polymer, has several unique properties such as aqueous processability, biocompatibility, and biodegradability. Due to these advantageous properties, it is promising for applications in various fields, especially drug delivery. In this paper, the simple preparation of SF microspheres was discussed via self-assembly. Some of SF＇s physicochemical properties and morphology were also investigated. The results show that the morphology, size and size distribution of silk microspheres depend upon various processing parameters, especially including volume ratios among SF, ethanol and polyvinyl alcohol （PVA）. Regular silk microspheres were obtained in PVA solution when adjusting the volume ratios of silk to ethanol from 20：1 to 20： 9. We also found that SF microspheres with various appearances were formed by addition of different PVA solution concentrations under a constant silk solution to ethanol volume ratio. From the Fourier transform infrared spectroscopy（FTIR） of silk microspheres, it was found that introducing ethanol into the SF solution induced conformational change from random coil to β-sheet. Additionally, under the observation of scanning electron microscopy （ SEM）, the shape of self-assembled silk microspheres was determined to be spherical. Finally, SF＇s potential as drug delivery carriers was discussed in the experimental results.     

三维SHPB装置设计及原理研究

针对一维SHPB实验设备无法进行三维预应力不等值情况下的冲击实验问题,在确保中国矿业大学(北京)原有一维SHPB实验装置中动力发射系统及子弹不改变的前提下,设计了可以进行对试件进行三维施压的正方形输入杆、输出杆、吸收杆及输入杆中与子弹接触部位由圆变方的过渡杆装置,采用应力波基础理论分析和数值模拟的方法,得到了过渡杆中的应力波传播规律,研究结果表明:应力波在圆变方扩散杆中传播时,由于强度吸收现象,过渡杆越长,波幅下降的程度就越低,当长度达到500 mm时,应力波在其中的弥散现象已经很小,能够满足整个实验系统的准度要求.      

A multi-path routing algorithm of LEO satellite networks based on an improved ant colony system

Geography rectangle is used to reduce signaling overhead of the LEO satellite networks.Moreover,a multi-path routing algorithm based on an improved ant colony system （MPRA-AC） is proposed.Matrix indicating the importance of the link between satellites is introduced into MPRA-AC in order to find the optimal path more quickly.Simulation results show that MPRA-AC reduces the number of iterations to achieve a satisfactory solution.At the same time,the packet delivery ratio of LEO satellite networks when running MPRA-AC and DSR-LSN （dynamic source routing algorithm for LEO satellite networks） is compared.The packet delivery ratio is about 7.9％ lower when running DSR-LSN.Moreover,because of the mechanism of active load balancing of MPRA-AC,simulation results show that MPRA-AC outperforms DSR-LSN in link utilization when data packets are transmitted in the networks.     

深空通信中基于中继选择的文件传输协议

针对深空通信传播时延大、误码率高以及链路间歇性中断的问题,提出一种基于中继选择的深空文件传输协议。该协议将文件传输过程分为跳到跳发送和端到端重传2个阶段。在发送阶段,提出一种中继选择算法,通过分析天体运动规律选择合适的中继节点,并结合深空链路信道特点,分析链路丢包率和信道增益的关系,选择最优中继链路逐跳进行传输,降低丢包率进而减少重传次数;在重传阶段,目的端对数据包进行校验和检查,丢失的数据包通过端到端链路进行重传,保证文件的可靠传输。仿真结果表明,当端到端误码率大于10－5时,所提协议能有效减少重传次数,进而降低传输时延。在误码率为10－3时,与空间数据系统咨询委员会（consultative committee for space data systems,CCSDS）提出的文件传输协议（CCSDS file delivery protocol,CFDP）相比,该协议的传输时间缩短了40％,能较好地适应深空通信环境。     

穆斯堡尔效应对Fe(OH)_2在空气中氧化产物的研究

Fe(OH)_2的制备、颜色以及它的氧化产物,有各种不同的论述。本文通过穆斯堡尔效应的实验测定,确定了氧化程度不同,所生成的产物不同。     

SHPB技术研究混凝土动态力学性能存在的问题和改进

根据实验和理论分析,目前分离式Hopkinson压杆装置(SHPB)间接测量混凝土材料动态应力—应变关系时主要存在三方面问题,分别是应力应变不均匀的限制、大尺寸SHPB压杆产生的应力波弥散及数据处理时应力波波头选取的影响。上述问题使得用传统SHPB方法在研究混凝土材料动态力学性能时的可靠性和精确性大大降低。因此,该文对上述问题的解决和改善进行了初步探讨。     

钢坯切轧中咬入和轧制稳定性的研究

简介采用连铸板坯经1150初轧机切轧成方坯的切轧工艺、孔型设计及切分的基本原理;对轧制过程中轧件的运动状态及其对咬入和轧制稳定性的影响进行了分析。     

Transdermal Delivery of Piroxicam by Surfactant Mediated Electroporation

A lipophilic, nonsteroidal antiinflammation drug, piroxicam, was administered by skin electroporation using short, high-voltage pulses. The transdermal delivery of piroxicam during the electroporation was buffered due to the higher partition in skin lipids than in aqueous environments, which is called entrapment. Entrapment is the main resistance to transdermal delivery of lipophilic drugs. Two types of surfactants were used to enhance the skin electroporation. Tween 80 （0.2 g/L） and sodium dodecyl sulphate （SDS, 3 mg/mL） improve the solubility and diffusion rate of the drug in the hydrophobic local transport regions and reduce the entrapment of piroxicam in the skin. The transdermal delivery rate of piroxicam is increased 30- to 50-fold. However, the entrapment of piroxicam in the skin still occurred when Tween 80 was added. The SDS provides higher and more stable transdermal delivery rates of piroxicam than Tween 80, and also reduces the entrapment of piroxicam in the skin.     

一种可用于分类型属性数据的多变量决策树算法

针对绝大部分多变量决策树只能联合数值型属性,而不能直接为带有分类型属性数据集进行分类的问题,提出一种可联合多种类型属性的多变量决策树算法(CMDT).该算法通过统计各个分类型属性的属性值在各个类别或各个簇中的频率分布,来定义样本集合在分类型属性上的中心,以及样本到中心的距离.然后,使用加权k-means算法划分决策树中的非终端结点.使用这种结点划分方法构建的决策树可用于数值型数据、分类型数据以及混合型数据.实验结果表明,该算法建立的分类模型在各种类型的数据集上均获得比经典决策树算法更好的泛化正确率和更简洁的树结构.     

全毫米波异构网络混合回程及缓存协助内容传递方案

针对部分流行多媒体文件重复下载产生的额外流量消耗引起的网络阻塞问题,提出了一种混合自回程及缓存(hybrid self-backhaul and cache,HSBC)协助的内容传递方案。在同信道和全毫米波部署的异构网络中,基于配置因子η,部分小基站(small base station,SBS)配备缓存并按照流行度等级存储多媒体内容,而无缓存配备的SBS通过多天线宏基站的自回程为用户提供请求内容,毫米波技术的引入有效缓解了网络频谱稀缺问题。利用实际天线阵列方向图模型,研究了系统的覆盖概率、平均面积吞吐量和平均延迟。结果表明,HSBC协助系统相较传统自回程(traditional self-backhaul,TSB)协助系统获得的性能增益很大程度上取决于系统参数。据此,提出了一种自适应TSB-HSBC-SBS协助内容传递模型。当缓存SBS的当前比率因子小于阈值时,选择TSB-SBS协助模型;否则使用HSBC-SBS协助模型。