Nafion化学修饰钨丝圆盘预富集─石墨炉原子吸收法联用间接测定抗菌类药物头孢拉定的研究

本文研究了Ｎａｆｉｏｎ化学修饰钨丝圆盘预富集－石墨炉原子吸收法间接测定头孢拉定的方法，并探讨了测定的机理。在ｐＨ为６．９的Ｃｕ２＋液中，加入的头孢拉定与Ｃｕ２＋进行配合反应，使原来溶液中的Ｃｕ２＋量减少，于是交换到Ｎａｆｉｏｎ膜上的Ｃｕ２＋的量也相应减少，从而测得Ｃｕ２＋的吸光度信号下降。头孢拉定浓度在１．５×１０－６－１．０×１０－５ｍｏｌ／Ｌ范围内，与吸光度下降值呈良好的线性关系，平行测定十次，相对标准偏差为２．０％，最低检出限为１．０×１０－６ｍｏｌ／Ｌ。同时测得Ｃｕ２＋与头孢拉定的配合比为１∶２，条件稳定常数为６．９×１０９。实测药物中头孢拉定的含量，结果令人满意。     

In vivo Dynamic Studies of Brain Metabolism

Nuclear magnetic resonance （NMR） can noninvasively monitor intracellular concentrations and kinetic properties of numerous inorganic and organic compounds. A ^31p NMR surface coil was used in vivo to dynamically measure phosphocreatine （PCr）, adenosine triphosphate （ATP）, and intracellular inorganic phosphate （Pi） levels in mouse brain during ischemia-reperfusion to study the damage of cerebral tissues caused by ischemia and effects of herbs on cerebral energy metabolism during ischemia-reperfusion. The study provides dynamic brain energy metabolism data during different periods. The data show that some herbs more rapidly increase the PCr level during the recovery phase than in the control group.     

蒸发冷却+干式风机盘管半集中式空调系统探讨

在温湿度独立控制的原理基础之上，根据西北地区的气候特点，提出了干式风机盘管与蒸发冷却相结合的半集中式空调系统，并对该系统的设计过程进行了分析．实例表明，它不仅解决了目前蒸发冷却空调系统中存在的风管尺寸大、难以分室控制等问题，还比直流式全新风系统节省能耗21．9％以上．     

卷取张力控制新方法

介绍了一种新的卷取机张力控制方法,其关键技术在于取消传统动态力矩补偿,同时满足无冲击张力给定和升速过程中恒张力指标要求.采取的一系列措施后,这种新的方法已成功应用于高精度生产轧机.     

三相绕线式异步电动机无级起动控制的一种方法

三相绕线式异步电动机转子回路外接并联阻抗 ,可以改善起动性能 ,简化控制电路 ,适用于重复短时工作制负载的起动控制。讨论了阻抗参数的计算方法。     

Protein folding revisited. A polypeptide chain at the folding – misfolding – nonfolding cross-roads: which way to go?

The structure-function paradigm claims that a specific function of a protein is determined by its unique and rigid three-dimensional (3D) structure. Thus, following its biosynthesis on the ribosome, a protein must fold to be functional. This idea represents one of the cornerstones of modern biology. Numerous cases when, due to the effect of environmental factors or because of genetic defects (mutations), a polypeptide chain has lost its capability to gain a proper functional 3D structure (i.e. became misfolded), seem to confirm this concept. Consequences of such misfolding are well known and represent lost of function, aggregation, development of conformational disorders and cell death. However, the recent revelation of countless examples of intrinsically disordered proteins has cast doubt on the general validity of the structure-function paradigm and revealed an intriguing route of functional disorder. Thus, in a living cell, a polypeptide chain chooses between three potential fates – functional folding, potentially deadly misfolding and mysterious nonfolding. This choice is dictated by the peculiarities of amino acid sequence and/or by the pressure of environmental factors. The aim of the present review is to outline some interesting features of these three routes.Received 5 March 2003; received after revision 28 March 2003; accepted 31 March 2003     

电控单体泵电磁阀内阻尼油膜的挤压流动分析

电磁阀是决定所有电控燃油喷射系统性能的关键部件,其阻尼系统参数影响电磁阀的动态响应特性。为此运用平行平板间缝隙流动基本理论对存在于电磁阀衔铁和电磁铁之间的阻尼油膜进行了简化分析。计算结果与有限元方法对比,两者的相对误差只有2%。在此基础上进行了仿真分析,研究了各结构参数对衔铁阻尼特性的影响,为衔铁的设计和参数的匹配提供了依据。     

1Cr18Ni9Ti不锈钢的双频电磁约束成形工艺参数优化

根据高频磁场利于感应加热、低频磁场利于熔体成形的特点，针对不锈钢(1Cr18Ni9Ti)密度大、熔点高和约束成形的熔体高度低等成形困难的特点，提出了利用低频磁场约束成形、高频磁场在不影响成形磁场的条件下辅助加热的不锈钢双频电磁约束成形方法，以便温度场和成形力场的最佳耦合．通过实验和理论分析，设计了不锈钢双频电磁约束成形的成形感应器和预热感应器，并确定了感应器间的距离和屏蔽罩的放置方式，研究了预热感应器对温度场的影响规律，从而建立了不锈钢的双频电磁约束成形系统．在对熔体的稳定成形分析的基础上，利用双频电磁成形系统成功抽拉出圆形不锈钢样件．     

核磁共振成像用磁体的计算机辅助设计

核磁共振成像用的磁体要求在一定的磁场强度下保持大范围的均匀度。本文给出球形空芯磁体和环形空芯磁体的计算机辅助设计方法。     

磁性研磨感应器电磁线圈的两种计算

对用电压线圈法和电流线圈法计算电磁线圈参数两种方法进行了比较,并建议电磁感应器的电磁线圈应尽量采用电流线圈.