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41.
运用时窗复杂度序列来分析睡眠脑电,减少了非平稳性及状态空间的不均匀性造成的脑状态信息的丢失,在一定程度上克服了复杂度的自身的局限,有助于不同睡眠期状态特征的提取.另外本文采用ICA、小波变换等方法对脑电进行预处理,实验表明它们能有效地去除脑电中的一些生理干扰,有利于提高复杂度算法在睡眠分期应用中的精确度. 相似文献
42.
Malaguarnera L 《Cellular and molecular life sciences : CMLS》2006,63(24):3018-3029
The enzyme chitotriosidase (ChT), the human analogue of chitinases from non-vertebrate species, is one of the most abundant
and indicative proteins secreted by activated macrophages. Its enzymatic activity is elevated in serum of patients suffering
from Gaucher’s disease type 1 and in some other inherited lysosomal storage disorders, as well as in diseases in which macrophages
are activated. The last decade has witnessed the appearance of a substantial number of studies attempting to unravel its cellular
functions, which have yet not been fully defined. A great deal of progress has been made in the study of the physiological
roles of ChT. This review is looks at the key areas of investigations addressed to further illuminate whether ChT activation
might have different functional meanings in various diseases.
Received 7 June 2006; received after revision 24 July 2006; accepted 21 September 2006 相似文献
43.
44.
Zisapel N 《Cellular and molecular life sciences : CMLS》2007,64(10):1174-1186
Sleep is a neurochemical process involving sleep promoting and arousal centers in the brain. Sleep performs an essential restorative
function and facilitates memory consolidation in humans. The remarkably standardized bouts of consolidated sleep at night
and daytime wakefulness reflect an interaction between the homeostatic sleep need that is manifested by increase in sleep
propensity after sleep deprivation and decrease during sleep and the circadian pacemaker. Melatonin, the hormone produced
nocturnally by the pineal gland, serves as a time cue and sleep-anticipating signal. A close interaction exists between the
sleep-wake, melatonin, core temperature, blood pressure, immune and hormonal rhythms leading to optimization of the internal
temporal order. With age the robustness of the circadian system decreases and the prevalence of sleep disorders, particularly
insomnia, increases. Deviant sleep patterns are associated with increased risks of morbidity, poor quality of life and mortality.
Current sleep pharmacotherapies treat insufficient sleep quantity, but fail to improve daytime functioning. New treatment
modalities for sleep disorders that will also improve daytime functioning remain a scientific and medical challenge. 相似文献
45.
Deboer T 《Cellular and molecular life sciences : CMLS》2007,64(10):1227-1235
Sleep is investigated in many different ways, many different species and under many different circumstances. Modern sleep
research is a multidisciplinary venture. Therefore, this review cannot give a complete overview of all techniques used in
sleep research and sleep medicine. What it will try to do is to give an overview of widely applied techniques and exciting
new developments. Electroencephalography has been the backbone of sleep research and sleep medicine since its first application
in the 1930s. The electroencephalogram is still used but now combined with many different techniques monitoring body and brain
temperature, changes in brain and blood chemistry, or changes in brain functioning. Animal research has been very important
for progress in sleep research and sleep medicine. It provides opportunities to investigate the sleeping brain in ways not
possible in healthy volunteers. Progress in genomics has brought new insights in sleep regulation, the best example being
the discovery of hypocretin/orexin deficiency as the cause of narcolepsy. Gene manipulation holds great promise for the future
since it is possible not only to investigate the functions of different genes under normal conditions, but also to mimic human
pathology in much greater detail. 相似文献
46.
From Creutzfeldt-Jakob disease (CJD) to variant CJD through Gerstmann-Str?ussler-Scheinker syndrome, kuru and fatal familial insomnia, the journey leading to current understanding of the basic aspects of human prion diseases has been full of unexpected, but often dramatic and always fascinating twists. Recent progress in modeling prion diseases and characterization of the various prion protein forms reveal that such a wide spectrum of the diseases is associated with the chameleon-like conformational features of prions. 相似文献
47.
Delhommeau F Pisani DF James C Casadevall N Constantinescu S Vainchenker W 《Cellular and molecular life sciences : CMLS》2006,63(24):2939-2953
Myeloproliferative disorders (MPDs) are clonal haematopoietic malignancies involving the abnormal proliferation of myeloid
lineages. The World Health Organisation (WHO) classification of haematopoietic malignancies distinguishes MPDs from myelodysplastic/
myeloproliferative disorders and systemic mastocytosis. These malignancies frequently involve constitutive tyrosine kinase
activity, resulting from either oncogenic fusion protein production or from point mutations. Chronic myelogenous leukaemia
is the model used for studies of the consequences of such molecular defects. However, the heterogeneity of the clinical course
of MPDs should be seen in a more rationale conceptual framework, including the many molecular events associated with these
diseases. This review focuses on the various tyrosine kinase-related molecular mechanisms underlying both MPDs and rare diseases
with myeloproliferative features. We pay particular attention to the newly identified JAK2 V617F mutation in polycythaemia
vera, essential thrombocythaemia and idiopathic myelofibrosis and deal with disease heterogeneity and putative additional
molecular mechanisms.
Received 9 June 2006; received after revision 28 July 2006; accepted 11 September 2006 相似文献
48.
49.
G. Zoccoli T. Cianci P. Lenzi C. Franzini 《Cellular and molecular life sciences : CMLS》1992,48(3):228-230
The present study considers in rabbit: i) the relationship between muscle blood flow (BF) increase and fiber-type composition during shivering; ii) the influence of the vigilance states (Quiet Wakefulness, QW; Synchronized Sleep, SS; Desynchronized Sleep, DS) on this relationship. The results show that muscle BF increase during shivering is proportional to the slow-twitch oxidative (SO) fiber component in QW and SS; in DS the proportionality is lost. This is in accordance with the disappearance of shivering, together with all thermoregulatory effector responses, in this sleep state. Another muscle circulation pattern occurring at low ambient temperature, the relationship between BF increase and muscle depth, also disappears in DS. This confirms that the integrative control of muscle circulation, like other integrative mechanisms, is impaired during DS. 相似文献
50.
Franciosi S 《Cellular and molecular life sciences : CMLS》2001,58(7):921-930
α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptors are one type of ionotropic glutamate receptor involved
in rapid excitatory synaptic transmission. AMPA receptors have been increasingly implicated in long-term potentiation, and
recent evidence suggests that they may play a role in disorders affecting the nervous system. The finding that early in postnatal
development AMPA receptors are not expressed has lately been the focus of much attention. Resolving the factors involved in
AMPA receptor expression suggests that their induction is a developmentally regulated process with the possibility that alterations
in receptor expression may be correlated with pathology in neurological disorders. This paper provides an overview of factors
involved in AMPA receptor induction as well as of their role in plasticity and neuronal pathologies.
Received 5 December 2000; received after revision 12 January 2001; accepted 2 February 2001 相似文献