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151.
Metabonomic analysis of hepatitis B virus-induced liver failure: identification of potential diagnostic biomarkers by fuzzy support vector machine
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Yong MAO ;Xin HUANG ;Ke YU ;Hai-bin QU ;Chang-xiao LIU ;Yi-yu CHENG 《浙江大学学报(自然科学英文版)》2008,(6):474-481
Hepatitis B virus (HBV)-induced liver failure is an emergent liver disease leading to high mortality. The severity of liver failure may be reflected by the profile of some metabolites. This study assessed the potential of using metabolites as biomarkers for liver failure by identifying metabolites with good discriminative performance for its phenotype. The serum samples from 24 HBV-indueed liver failure patients and 23 healthy volunteers were collected and analyzed by gas chromatography-mass spectrometry (GC-MS) to generate metabolite profiles. The 24 patients were further grouped into two classes according to the severity of liver failure. Twenty-five eommensal peaks in all metabolite profiles were extracted, and the relative area values of these peaks were used as features for each sample. Three algorithms, F-test, k-nearest neighbor (KNN) and fuzzy support vector machine (FSVM) combined with exhaustive search (ES), were employed to identify a subset of metabolites (biomarkers) that best predict liver failure. Based on the achieved experimental dataset, 93.62% predictive accuracy by 6 features was selected with FSVM-ES and three key metabolites, glyeerie acid, cis-aeonitie acid and citric acid, are identified as potential diagnostic biomarkers. 相似文献
152.
Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers
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Ming-zhu HUANG Jian-zhong SHENTU Jun-chun CHEN Jian LIU Hui-li ZHOU 《浙江大学学报(自然科学英文版)》2008,(2):114-120
This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS). An Alltima-C18 column (2.1 mm×100 mm, 3 μm) and a mobile phase consisting of 0.1% formic acid-acetonitrile (40:60, v/v) were used for separation. The analysis was performed by selected reaction monitoring (SRM) method, and the peak area of the m/z 411.3→191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25-50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%-9.09% and 1.56%-4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%-84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent. 相似文献
153.
云南在建设社会主义和谐社会进程中面临着许多不利的因素,只有以科学发展观为指导,清醒地认识这些不利因素,把这些因素作为工作和决策的出发点,确定明确发展的基本思路,采取切实有效的措施,才能真正推进社会主义和谐社会的发展。 相似文献
154.
“靓”本是一个古语词和方言词,曾一度消失于汉语普通话中。随着粤语的北上,“靓”由粤方言进入共同语中泛化使用。近十余年来,“靓”的使用在全国尤其是在粤港地区人们日常生活口语中呈现一种滥用的状态,其词义的感情色彩在逐渐发生转移。 相似文献
155.
Jianhua Liu Yong Wei 《系统科学与信息学报》2008,6(1):91-96
This article gives the algorithm of the sector in which the development coefficient is, and the steps to simultaneously calculate the development coefficient and combination coefficient of background value. Unifying the development coefficient and the background value's coefficient of combination to optimize the model together, avoiding the malpractice to separate the two in traditional method, and avoiding the error brought out by matrix multiplication because of matrix's illness and so on in the traditional way, therefore increases the precision of the model. 相似文献
156.
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158.
在复合地质条件掘进时刀盘载荷与撑靴接触界面的耦合关系严重影响硬岩掘进机(TBM)动态特性.基于并联机构理论研究TBM推进系统的力传递特性,建立刀盘、机械系统和撑靴接触刚度耦合力传递模型,讨论了刀盘在复合地质条件下掘进时刀盘载荷波动与撑靴岩石接触界面刚度之间的耦合关系.结果表明,撑靴接触界面刚度随刀盘载荷增大而非线性增大;复合地层中,刀盘载荷波动,接触界面刚度也呈现相应的波动特性;两侧撑靴接触界面岩石软硬不同时,刀盘载荷均值和波动增加,接触界面刚度均值和波动加大,且较硬一侧增加幅度大于较软一侧减小幅度. 相似文献
159.
基于响应面法(RSM),通过一系列的实验建立了薄壁蜡模壁厚方向的收缩率与压蜡参数之间的数学模型,并对模型的合理性与充分性进行了方差分析,对压蜡过程中工艺参数对尺寸收缩率的影响进行了敏感性分析.为了减小收缩率,基于遗传算法(GA)对工艺参数进行了全局优化. 相似文献
160.
The shrinking of cell-size brings significant changes to the wireless uplink of densely small cells (DSCs). A codebook design is proposed that utilizes the strong line of sight (LOS) chan- nel component existing in a DSC system for uplink of the DSC system. To further improve the uplink performance, the high-rank codebook is designed based on singular value decomposition (SVD) due to the unnecessary preservation of strict constant modulus in the DSC system. And according to the simulation result, the proposed codebook leads to significant sum-rate gain and appreciable block error rate (BLER) performance improvement in the DSC system. 相似文献