Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of α-lactalbumin

Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human -lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice for 3 days. Exposure of mammary tissue to HAMLET resulted in morphological changes typical for apoptosis and in a stimulation of caspase-3 activity in alveolar epithelial cells near the HAMLET pellets but not more distant to the pellet or in contralateral glands. The effect was specific for HAMLET and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone. HAMLET also induced cell death in vitro in a mouse mammary epithelial cell line. The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissue.Received 30 January 2004; received after revision 5 March 2004; accepted 16 March 2004     

Fine mapping of the dominant glandless Gene Gl2^e in Sea-island cotton （Gossypium barbadense L.）

Gle2 is a mutant gene that controls glandless trait in cotton plants and seeds. It is an important gene resource to gossypol-free cottonseed breeding. The objective of this research was to develop SSR markers tightly linked with Gle2 by using the F2 segregating population containing 1599 plants derived from the cross of G. hirsutum genetic standard line TM-1 and G. barbadense glandless mutant line Hai-1. Genetic analysis suggested that the Gle2 was an incomplete dominant gene. Based on the backbone of genetic linkage map from G. hirsutum × G. barbadense BC1 published by our laboratory,Gle2 was lo-cated between CIR362 and NAU2251b,NAU3860b,STV033,with a genetic distance 9.27 and 0.96 cM,respectively. This result is useful for cloning Gle2 gene by map-based cloning method.     

基于超球形的多播密钥更新方法

多播安全要确保所有参加多播的成员安全地共享同一组密钥,当有成员加入或离开时需要及时更新组密钥.当组播规模很大时,更新组密钥的效率是一个重要的问题.在研究密钥更新的基础上,提出一种基于超球形的多播密钥更新模型.该模型充分利用成员之间既有独立性又有协同性的特点,解决密钥更新问题,该方法更新效率高,组管理器储存密钥总数少.算法较LKH和OFT有优势.     

IEEE802.16e跨层切换的性能分析

目的为了提高切换性能,将快速分层移动IPv6(F-HM IPv6)应用到IEEE802.16e中提出了一种新跨层切换方法。方法通过将MAC层切换和IP层切换有效结合,使MAC层切换和IP层切换交叉进行。结果该方法与现有的切换方法相比,具有更小的切换时延和服务中断时间。对不同的切换方法的数据传输时间进行了分析,不同的参数对数据传输时间有不同的影响。结论该方法具有好的切换性能。     

一类图的优美性

设￣／Ｑｎ（ｎ≥３，ｎ∈Ｎ）表示王冠Ｑｎ的回路Ｃｎ上的每相邻顶点之间都加入一个顶点后得到的图，证明了图￣／Ｑｎ都是优美图。     

乘性单调张成方案的构造

乘性单调张成方案是实现安全多方计算的重要工具．构造乘性的单调张成方案对安全多方计算至关重要．对任意的存取结构，CRAMER等给出了一种构造方法，但构造出来的乘性单调张成方案的行规模变成原来的两倍，而列规模也增加了．文章提出一种新的构造方法，在不改变列规模的前提下，该方法可以构造出行规模小于原来的2倍的乘性单调张成方案．     

借记卡安全电子支付的身份认证协议研究

为了加强借记卡处理安全电子交易（SET）协议的身份认证，在SET支付协议的基础上，提出了两种对借记卡身份进行认证的协议，使借记卡可以进行SET支付，第一种协议是在SET协议中增加个人密码的加密传输，第二种协议是采用服务器钱包模型，由服务器钱包对借记卡进行身份认证和余额检查，这两种协议可适应不同情况，较好地解决了SET协议对借记卡的支持。     

A NOTE ON A.E.CONVERGENCE OF FOURIER-LAPLACE SERIES IN L2*

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可测函数列关于谱测度几乎处处收敛的若干特征

本文把可测函数列几乎处处收敛的几个重要特征推广到谱测度的情形，并证明了它们之间的相互等价性．     

学习国内外先进经验实现全方位的管理创新

本文介绍和分析了美国及国内先进企业全方位管理创新的经验 ,值得我们在企业技术创新中学习和借鉴。