Synthesis of 2,4-dibromo-5-fluorobenzonitrile

2,4-Dibromo-5-fluorobenzonitrile has been synthesized for the first time (81.5% yield). It may be used in synthesizing 2,4-dibromo-5-fluorobenzoic acid, the intermediates of fluoroquinolones. The ammoxidation procedure for preparation of the nitrile has been described in detail. Zheng Qiong: born in 1945, Associate professor     

硝酸洗涤剂对磷钼酸铵沉淀组成的影响

本文通过实验证实,磷钼酸铵沉淀与硝酸洗涤剂之间发生离子交换作用。经用稀硝酸洗涤后,部分沉淀的组成由(NH_4)_3PO_4·12MoO_3·nH_2O转变成为(NH_4)_2HPO_4·12MoO_3·nH_2O。并由此提出化学式(NH_4)_2HPO_4·12MoO_3·nH_2O不能代表磷钼酸铵沉淀的初始组成。     

D-Amino acids in mouse tissues are not of microbial origin

Summary Neutral free D-amino acid contents in the serum, kidney, liver, brain, small intestine and urine in germ-free mice and those in specific pathogen-free mice were compared. No significant difference was found. This strongly suggests that the free D-amino acids which were shown to be present in mice in our previous work^{1, 2} did not originate from the enteric microbial flora.     

新取代苯并冠醚的合成

以聚磷酸为催化剂和反应溶剂，合成了卤代乙酰型取代苯并冠醚Ａ、Ｂ、Ｃ和乙酰型取代冠醚Ｄ，四种合成产物由ＩＲ，ＭＳ和元素分析鉴定了结构。     

M(II)..甲酰基甲酸缩氨基硫脲二元配合物稳定性

M( II) - -甲酰基甲酸缩氨基硫脲具有杀茵活性。为了深入对具有杀茵活性配合物性质的研究 ,我们合成了甲酰基甲酸缩氨基硫脲 (缩写为 H2 A) ,应用 p H电位滴定法测定了 H2 A的质子化常数和二元配合物 M( II)- - H2 A( Cu2 ,Zn2 ,Co2 ,Ni2 ,Mn2 )稳定常数 ,并讨论了其稳定性     

潘二矿煤系高岭岩脱除Fe_2O_3工艺的研究

本文通过对潘二矿煤系高岭岩脱杂工艺实验，认为较佳脱杂效果的工艺条件为焙烧温度430℃，浸出温度120℃，盐酸浓度20％，浸出时间120min。     

酸性红BG染料的合成研究

利用2，5-二氨基苯磺酸为原料合成2-氨基-5-乙酰氨基苯磺酸，并进一步经2-氨基-5-乙酰氨基苯磺酸重氮盐与γ酸的偶合反应合成了酸性红BG（CIAcidRed37），并对影响反应的因素进行了讨论．     

山梨酸的合成

采用另一条合成路线，即以巴豆醛和丙酮为原料，先生成巴豆烯叉丙酮，再经氧化而得山梨酸。该法工艺要求低，原料易得。对其工艺进行了试验研究，并对影响产率的各种因素进行初步探讨。在选一条件下，产率为60.2％。     

Acute toxicity of folic acid in mice

Summary The toxicity of folic acid (PGA) was studied in different inbred strains of mice. LD₅₀ values of PGA by the i.p. route showed a unique toxicity pattern. In some strains, convulsions, ataxia and weakness were observed. Histopathological study in strains S/RVCri, BDF₁, DBA/2 and DBA/2fNCri showed acute renal tubular necrosis.Acknowledgment. The authors thank Ms N. Hasgekar for her technical assistance     

2-氯丙酸法制备甲基丙二酸二乙酯

以２－氯丙酸为原料，经氰化、水解、酯化制得甲基丙二酸二乙酯，总收率４１％。