高校物流实验室建设探析

分析了高校建设物流实验室的必要性和总体目标,对物流实验室实训方案设计的基本思路、具体实训课程计划等问题进行了探讨,总结了高校物流实验室建设存在的误区和需要注意的问题。     

铁路电气化工程开通方案研究

文章介绍了电气化铁路施工完成后开通应具备条件、开通组织机构和试运行组织机构。结合近年来本单位在铁路电气化施工中的开通经验，全面分析了牵引变电所和接触网送电开通方案，以确保电气化铁路一次送电成功。     

Optimum design of equivalent accelerated life testing plans based on proportional hazards-proportional odds model

The optimum design of equivalent accelerated life testing plan based on proportional hazards-proportional odds model using D-optimality is presented.The defined equivalent test plan is the test plan that has the same value of the determinant of Fisher information matrix.The equivalent test plan of step stress accelerated life testing(SSALT) to a baseline optimum constant stress accelerated life testing(CSALT) plan is obtained by adjusting the censoring time of SSALT and solving the optimization problem for each case to achieve the same value of the determinant of Fisher information matrix as in the baseline optimum CSALT plan.Numerical examples are given finally which demonstrate the equivalent SSALT plan to the baseline optimum CSALT plan reduces almost half of the test time while achieving approximately the same estimation errors of model parameters.     

浅谈高速公路施工中强夯路基监理

由于高速公路建设要求高、工期短、点多面广范围大,在施工中需要不断创新,运用新技术、新工艺成为必然。近年来,强夯路基技术在高速公路中广泛使用,并且取得了一定的效果。文章结合广东某高速公路强夯法的施工监理进行探讨。     

论图书馆员职业发展规划及其完善

职业发展的规划和完善对于图书馆员及图书馆发展至关重要。而当前的图书馆员在职业发展规划上存在职业意识薄弱、职业层级单一、职业竞争力不强、职业教育管理缺失等诸多问题。因此,需从上述几个方面来加强图书馆员的职业规划。     

浅谈北京地铁六号线星火路站车站主体结构施工

文章主要论述了北京地铁六号线星火路站车站主体结构的施工方案。     

形象进度图法编制桥梁工程施工进度计划

文章提出了工程进度计划编制常用方法横道图和网络计划图的优缺点,介绍了形象进度计划图法的编制方法,并以此法举例编制大桥进度计划,指导大桥开工后的施工组织安排。     

青海省高校健美操教学对全民健身的影响与现状分析

本文通过文献资料法、调查法、逻辑分析等方法,通过对健美操教学与全民健身的关系进行论述,从体育学、社会学、心理学等多角度对健美操教学对全民健身的影响与优势进行新的审视,重点探讨和提出了健美操教学在全民健身中的作用,其目的是让人们更加明确地认识到健美操教学在全民健身中的重要性、独特性以及在教学中应注意的问题,旨在推动健美操运动在学校乃至社会各界更为广泛的开展.     

武汉市"十一五"规划战略环境评价实践

以武汉市"十一五"规划战略环境评价为例,探讨了我国城市国民经济和社会发展规划战略环境评价的技术路线、指标体系与评价方法.研究表明,对城市空间布局、产业布局、产业结构以及城市交通的环境适宜性进行综合评价是这类规划战略环境评价的重要特征;互动式的评价模式能使环境因素及时、有效地纳入到决策过程中;指标体系是预测评价的基础,指标的选择除考虑科学性、代表性外还应强调可获得性、可量化性及可考核性.     

Digoxin and ouabain increase the synthesis of cholesterol in human liver cells

Digoxin and ouabain are steroid drugs that inhibit the Na⁺/K⁺-ATPase, and are widely used in the treatment of heart diseases. They may also have additional effects, such as on metabolism of steroid hormones, although until now no evidence has been provided about the effects of these cardioactive glycosides on the synthesis of cholesterol. Here we report that digoxin and ouabain increased the synthesis of cholesterol in human liver HepG2 cells, enhancing the activity and the expression of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of the cholesterol synthesis. This effect was mediated by the binding of the sterol regulatory element binding protein-2 (SREBP-2) to the HMGCR promoter, and was lost in cells silenced for SREBP-2 or loaded with increasing amounts of cholesterol. Digoxin and ouabain competed with cholesterol for binding to the SREBP-cleavage-activating protein, and are critical regulators of cholesterol synthesis in human liver cells. Received 10 January 2009; received after revision 11 February 2009; accepted 6 March 2009