A new indolic antiauxin, α-(5,7-dichloroindole-3-)isobutyric acid: its chemical synthesis and biological activity

Summary A new potent antiauxin, -(5,7-dichloroindole-3-)isobutyric acid has been synthesized and shown to inhibit auxin-mediated elongation ofAvena coleoptiles and to stimulate root growth of rice seedlings. Its activity is stronger than -(p-chlorophenoxy)isobutyric acid and is comparable to that of 2,3,5-triiodobenzoic acid, which are typical antiauxins.     

滇东牛头山地区早震旦世沉积相及大地构造环境

野外调查和室内分析表明,牛头山地区陆良组、牛头山组应属下震旦统,其沉积相类型自下而上可划分为辫状河相、河口湾相、浅海相、滨海相、浅海相及三角洲相。“牛头山古陆”在早震旦世是不存在的。牛头山地区当时为被动大陆边缘。     

城市化途径及其相关

对城市化途径有关各要素作了综合的叙述,并且指出研究的手段──自人口的聚集至城镇形成发展这一历史的纵剖面及地域、产业结构等横向有关要素作整体系统的分析与比较,并指出应重点研究人口指标分析、产业可比关系、城市化和城市化设施,以及城市体系的研究问题。     

华佗再造丸治疗脑血管病疗效评估

用华佗再造丸治疗脑血栓、脑出血及其后遗症52例,其有效率达90.5％,对照组20例,10例脑出血用20％Mannitol及止血剂治疗,10例脑血栓用低分子右旋糖酐及脑络通治疗,有效率为70％,有高度显著性差异,P<0.001,笔者认为该药是治疗脑血管病较理想的中成药,具有镇静神经,滋阴强心,舒经活络,活血化瘀等作用。对病程短的年纪青的病人的疗效更为显著,脑出血性与脑缺血性疾病均有疗效,正是中药一药多用、一药多治的微妙体现。推测对脑血管病后遗症有效可能与该药能促进神经再生因子(NGF)的合成和利用有关。     

Proopiomelanocortin expression in the skin during induced hair growth in mice

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti -endorphin in late but not early anagen or telogen skin. By immunocytochemistry, -endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.     

Purification of platelet-derived endothelial cell growth inhibitor and its characterization as transforming growth factor-β type 1

In 1986, Brown and Clemmons (Proc. natl Acad. Sci. USA83 (1986) 3321) showed that platelets contain a substance, platelet-derived growth inhibitor (PDGI), that inhibits in vitro endothelial cell replication. Although platelets are rich in transforming grwoth factor (TGF-), PDGI was considered not to be related to TGF-, on the basis of its reported properties (extraction from platelets at neutral pH, binding to heparin-Sepharose). However, we purified PDGI to near homogeneity and showed that on the basis of HPLC retention behavior, in vitro growth inhibitory activities with several cell types, receptor binding, and immunoneutralization of growth inhibitory activity with specific anti-TGF- type 1 antibodies, PDGI is most probably identical with TGF- type 1.     

In vitro mutagenicity testing of a potent,new, benzoyl urea insect growth regulator

Summary Bacterial mutagenicity assay to detect potential chronic toxicity of a potent, new, benzoyl urea insect growth regulator (CGA-112913 or IKI-7899, formerly UC-62644) was conducted using 5 histidine auxotrophs ofSalmonella typhimurium. Tests within the concentration range of 0.9–500 g (saturating)/plate of the compound with and without the 5–9 mammalian metabolic activation system showed no mutagenic effects clearing the way for long-term chronic toxicology studies.The authors thank Professor Bruce N. Ames for supplying the tester strains together with all the relevant information for conducting the bioassays and Ms. Norma Charlebois for her meticulous technical assistance.     

An enzyme immunoassay for mouse epidermal growth factor utilizing a liquid phase double-antibody system

Summary An enzyme immunoassay for mouse epidermal growth factor (EGF) involving a liquid phase double-antibody system was developed. The EGF--galactosidase conjugate prepared was stable for at least 8 months. By this method, EGF was detectable at a concentration as low as 20 pg per tube. The concentrations of EGF in various tissues of mice are also presented.This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.     

华北克拉通恒山地区晚太古代变质火山岩的地球化学特征及构造意义

对恒山地区出露的变质火山岩开展岩相学、地球化学、锆石U-Pb年代学和Hf同位素研究,旨在确定其形成时代,探讨岩石成因及地球动力学意义。锆石U-Pb定年结果表明,这些变质火山岩喷发于新太古代晚期(2508±20Ma)。地球化学分析结果显示,恒山变质火山岩由变质玄武岩和变质玄武安山岩组成,SiO₂(45.51%～62.67%)、FeO_T (4.43%～15.72%)和MgO (3.75%～8.14%)含量变化幅度大,是幔源岩浆经单斜辉石、角闪石和磁铁矿分离结晶的产物。这些变质火山岩富集轻稀土(LREE)和大离子亲石元素(LILE),亏损重稀土(HREE)和高场强元素(HFSE),具有相对高的Th含量和Th/Yb比值,呈现钙碱性岛弧火山岩的特征。结合不相容元素比值Nb/Yb,Zr/Yb和(Nb/La)_N的特点,推测其来源于俯冲带具流体交代特征的富集地幔源区。结合区域构造背景,推断恒山变质火山岩形成于新太古晚期大陆弧环境。     

胶东-辽东-朝鲜巨型金矿集中区的分离

胶东、辽东、朝鲜北部三区在地质上表现出了极大的相似性和稳定性。它们不但在元古代地层上可以相互对比,而且还有着一个统一的硼的地球化学省,在大地构造单元上也可以相互衔接。三区可以拼合为一个整体,使辽东的丹东金矿区、朝北的平安北道金矿区和胶东的招掖金矿区正好合成一个完整的整体,构成了一个巨大的金矿集中区。这个巨型金矿集中区是在统一的古陆块上由同一成因作用形成的,后因大陆的张裂和离散被分离。文中对它的分离机制和过程进行了探讨。