复方血栓通胶囊基于原料药材与药效相关联的组方规律研究

基于灰色关联分析方法,研究复方血栓通胶囊组方中各味药材与药效间的关联性,科学解释其组方配伍规律。在复方血栓通胶囊原有配方比例的基础上,利用均匀设计调整组方中各味药材含量比例,获得复方血栓通差异样品;并进行动物药效实验考察诸差异样品活血化瘀的药效,获得其药效学数据。在此基础上运用灰色关联分析方法,分析差异样品与药效的关联性。研究表明:三七为复方血栓通活血化瘀药效的主要贡献者,对改善微循环障碍、调节凝血功能、缓解毛细血管及微小静脉堵塞起到重要作用;黄芪、丹参、玄参三味药材可显著降低血液中红细胞间的聚集性,从而使血液运行顺畅,防止血液高凝状态出现。四味药材作用各有特点又相互补充,合理发挥了其多靶点、多途径的调控作用。     

加味四妙胶囊抗痛风性关节炎实验研究

目的探讨加味四妙胶囊抗痛风性关节炎的作用.方法小鼠腹腔一次性注射氧嗪酸钾混悬液,制备小鼠高尿酸血症模型,检测血尿酸水平;采用尿酸钠诱导的小鼠痛风性关节炎模型,观察加味四妙胶囊对小鼠血尿酸及关节肿胀度的影响.结果与模型组比较,加味四妙胶囊对氧嗪酸钾引起的小鼠血尿酸升高有一定的抑制作用,可显著抑制尿酸钠诱导的小鼠关节肿大.结论加味四妙胶囊在小鼠动物实验中可降低血尿酸水平,对痛风性关节炎有一定的治疗作用.     

Smart Image Sensor with Integrated Low Complexity Image Processing for Wireless Endoscope Capsules

A smart image sensor was developed which integrates a digital pixel image sensor array with an image processor designed for wireless endoscope capsules. The camera-on-a-chip architecture and its on-chip functionality facilitate the design of the packaging and power consumption of the integrated capsule. The power reduction techniques were carried out at both the architectural and circuit level. Gray coding and power gating in the sensor array to eliminate almost 50% of the switch activity on the data bus and more than 99% of the power dissipation in each pixel at a transmitting rate of 2 frames per second. Filtering and compression in the processor reduces the data transmission by more than 2/3. A parallel fully pipelined architecture with a dedicated clock management scheme was implemented in the JPEG-LS engine to reduce the power consumption by 15.7%. The smart sensor has been implemented in 0.18 μm CMOS technology.     

手法配合痹祺胶囊治疗腰椎间盘突出症临床研究

为观察手法加痹祺胶囊治疗腰椎间盘突出症的临床疗效,对160例腰椎间盘突出症患者随机分为两组:治疗组病人80例,采用手法加痹祺胶囊治疗; 对照组病人80例, 只行痹祺胶囊治疗.经临床治疗显示: 治疗组总有效率为98.75%, 对照组为88.75%, 两组比较有显著性差异 (P＜0.05).临床治疗证明:手法配合痹祺胶囊治疗腰椎间盘突出症见效快,治愈率高.     

蓖麻蒴果剥壳力学特性的试验

为了实现蒴果壳与蓖麻籽成功剥离,载荷的大小以及载荷来自的方位相当重要.在蓖麻蒴果壳的物理特性测定分析基础上,运用接触力学对蓖麻蒴果脐部与顶部和腰部受到压载荷时,进行力学特性的试验分析与研究.结果显示蒴果在脐部与顶部受到压载荷作用时,果壳破裂的位置在蒴果顶部中缝处,中果皮内面产生裂纹而使蓖麻籽在果壳中脱出;蒴果在腰部受到压载荷作用时,果壳破裂的位置出现在蒴果中果皮中缝的两端,蒴果四周角靠近直线处也有裂纹而使蓖麻籽在果壳中脱出,蓖麻蒴果脐部与顶部受力大于腰部受力.     

潜空导弹运载器控制系统设计与仿真

变深度水平发射垂直出水是潜空导弹运载器的一项关键技术.针对垂直出水的弹道控制,建立了运载器仿真的数学模型;并在控制理论和经验数据的基础上,分析了潜空导弹运载器水弹道控制的特点,设计了PID控制器和模糊控制器.结果表明:设计的两种控制器,能够满足指标要求,模糊控制器具有更强的适应能力.     

复方红豆杉胶囊治疗老年中晚期肺癌24例临床观察

为观察复方红豆杉胶囊治疗老年中晚期肺癌的临床疗效,对24例无法行手术切除,且无法耐受或拒绝全身化疗及局部放疗老年中晚期肺癌患者,均给予复方红豆杉胶囊治疗3周期,观察肿瘤客观疗效,生存质量改善情况及不良反应。结果表明,①有效(CR+PR)18例,总有效率为75%;②治疗后平均KPS评分(80.35±6.81),较治疗前(62±7.14)显著升高,差异具有统计学意义(P0.05);③治疗后患者骨髓抑制最高为Ⅱ度,发生率仅为16.7%,仅1例患者发生轻度肝损伤。复方红豆杉胶囊能抑制肿瘤生长,提高患者生存质量。     

脑栓通胶囊对动脉粥样硬化小鼠血脂水平的影响

目的 观察脑栓通胶囊对动脉粥样硬化小鼠血脂水平的影响,探讨脑栓通胶囊治疗脑卒中的机制。方法 6周龄雄性Apo E -/- 小鼠,采用高脂饮食法建立动脉粥样硬化模型,造模成功后随机分为模型组、脑栓通胶囊低剂量组、脑栓通胶囊高剂量组。低剂量组给予脑栓通胶囊0. 5 g/kg体质量,高剂量组给予脑栓通胶囊1. 0 g/kg体质量,对照组给予等量的蒸馏水。连续给药12周后腹主动脉取血,分离血清。酶偶联比色法测定血清总胆固醇（total cholesterol,TC）、甘油三酯（triglyceride,TG）、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol,LDL-C）、高密度脂蛋白胆固醇（high density lipoprotein-cholesterol,HDL-C）水平。结果 与模型组相比,脑栓通胶囊低剂量组和高剂量组均显著降低血清中TC、TG和LDL-C的含量,但对HDL-C含量无影响。结论 脑栓通胶囊可以调节血脂水平,其治疗脑卒中的作用机制很可能与该途径有关。     

Dynamic characteristics of an intestine capsule robot with variable diameter

This paper proposes an intestine capsule robot with variable diameter. It is driven by external rotating magnetic field and has the function of automatic radial clearance compensation. An external magnetic field generating device and a capsule robot with variable diameter are developed. Radial dynamic balance equation and kinematics equation of the capsule robot traveling inside flexible elasto-wall environment are established, and dynamic characteristics of the capsule robot inside flexible elasto-wall pipe and rigid wall pipe environments are analyzed and compared. Simulations and experiment results show that its dynamic characteristics in both pipes are almost the same. Under the action of radial clearance compensation, fluid dynamic pressure around outer surface of the capsule robot and its propulsion, as well as its adaptability to diameter change range, are significantly improved. Its propulsion and moving speed are controlled by adjusting rotating angular speed of the rotating magnetic field. This innovative capsule robot with radial clearance compensation has a promising prospect for inside intricate gastrointestinal (GI) tract in non-invasive therapy applications.     

体内无线式内窥镜胶囊视频图像采集系统的设计

提出了一种新的数字无线式内窥镜胶囊视频图像采集系统。在对系统工作原理及其特点介绍的基础上,对微型成像系统中的图像采集和数据转换传输部分和无线发射部分进行了设计与改进,从而降低发射功耗,并减小电路尺寸。对所设计线路的实验测试表明:方案中的各系统部件调试工作正常,满足设计要求。