Molecular mechanisms in therapy of acid-related diseases

Inhibition of gastric acid secretion is the mainstay of the treatment of gastroesophageal reflux disease and peptic ulceration; therapies to inhibit acid are among the best-selling drugs worldwide. Highly effective agents targeting the histamine H2 receptor were first identified in the 1970s. These were followed by the development of irreversible inhibitors of the parietal cell hydrogen-potassium ATPase (the proton pump inhibitors) that inhibit acid secretion much more effectively. Reviewed here are the chemistry, biological targets and pharmacology of these drugs, with reference to their current and evolving clinical utilities. Future directions in the development of acid inhibitory drugs include modifications of current agents and the emergence of a novel class of agents, the acid pump antagonists. Received 30 May 2007; received after revision 15 August 2007; accepted 13 September 2007     

嫦娥三号“玉兔号”巡视器遥操作中的关键技术

2013年12月14日,"嫦娥三号"成功地将月面着陆器和"玉兔号"巡视器送抵月球,这标志着我国已完成了探月工程中"落"月的重要阶段.嫦娥三号任务的一个关键组成部分是由地面遥操作中心控制"玉兔号"巡视器在月面非结构化环境中进行巡视和科学探测,而遥操作技术正是该组成部分成功实施的关键."玉兔号"巡视器遥操作技术主要包括巡视器的导航定位、月面地形重构、行驶路径规划和机械臂探测等关键步骤,这些步骤相互支撑与融合,保证了嫦娥三号任务的顺利实施.本文在对上述4个方面关键技术的发展和应用现状进行总结的基础上,阐述了相关的主要技术途径及其应用特点,分析了各种技术在"玉兔号"月面巡视与科学探测任务实施中的发挥的重要作用,并评述了它们的发展潜力和应用前景,对中国探月工程以及后续火星探测工程中的遥操作具有一定的指导意义.     

基于多尺度光流融合特征点视觉-惯性SLAM方法

为提高视觉-惯性导航系统在弱纹理环境下的鲁棒性和精度,结合特征点法精度高和光流法速度快的特点以及惯性信息,提出一种多尺度均匀化光流融合特征点法的视觉-惯性同时定位与地图(simultaneous localization and mapping, SLAM)构建方法。首先,改进快速特征点提取和描述(oriented fast and rotated brief, ORB)特征提取过程,采用多尺度网格化的方法提取ORB特征点并利用四叉树均匀分配特征点,提高特征分布离散性。其次,在帧间采用LK(Lucas and Kanade)光流法追踪特征点进行帧间的数据关联,在关键帧对特征点进行描述子的计算和匹配从而实现关键帧间的数据关联,保证算法速度的同时提高定位精度和鲁棒性。最后,基于光流法建立的数据关联得到的初始位姿为后端优化提供初始值,整合ORB特征点重投影误差、惯性测量单元(inertial measurement unit, IMU)预积分误差以及滑动窗口先验误差构建最小化目标函数采用滑动窗口非线性优化进行求解。实验表明,所提方法相比单目视觉惯性系统具有更高的定位精度和鲁棒性,定位精度平均...     

极值分析下基于位置矩阵的质心定位方法

为以使星敏感器在复杂工况下依旧能获得高精度的星点质心位置,提出一种极值分析下基于位置矩阵的质心定位方法。首先, 提出极值分析下的星点弥散区域粗提取算法, 对去噪后的星图进行星点局部区域限定。接着, 提出基于位置矩阵的线段编码标记法对星点弥散区域进行精提取。最后, 利用星点区域像素信息估计出高斯曲面参数以得到星点精确的质心坐标。仿真结果表明, 星图噪声标准差处于2的水平时, 所提方法可以使星点质心定位精度达到0.070 4 pixel, 且在星图噪声标准差处于12的水平时, 仍具有90.03%的高星点提取成功率。     

浅析太原市滨河西路快速化改造工程的设计

结合太原市滨河西路快速化改造的设计方案和实践经验,重点介绍了以人为本的设计思路和交通规划理念,指出道路改造只有系统规划、综合改善,才能促进城市的可持续发展.     

Modeling and Experimental Study of PEM Fuel Cell Transient Response for Automotive Applications

This paper presents an analysis of the dynamic response of a low pressure proton exchange membrane (PEM) fuel cell stack to step changes in load, which are characteristic of automotive fuel cell system applications. The goal is a better understanding of the electrical and electrochemical processes when accounting for the characteristic cell voltage response during transients. The analysis and experiment are based on a low pressure 5 kW proton exchange membrane fuel cell (PEMFC) stack, which is similar to those used in several of Tsinghua's fuel cell buses. The experimental results provide an effective improvement reference for the power train control scheme of the fuel cell buses in Olympic demonstration in Beijing 2008.     

氢链中的质子孤波

研究了在非谐近似下.氢链中质子运动的动力学方程,并得到扭结孤波的解析解.与谐振近似相比较,结型孤波的对称性破坏,而离子型孤波的对称性基本上不受影响。     

The plasma membrane proton-translocating ATPase

Living cells require membranes and membrane transporters for the maintenance of life. After decades of biochemical scrutiny, the structures and molecular mechanisms by which membrane transporters catalyze transmembrane solute movements are beginning to be understood. The plasma membrane proton-translocating adenosine triphosphatase (ATPase) is an archetype of the P-type ATPase family of membrane transporters, which are important in a wide variety of cellular processes. The H+-ATPase has been crystallized and its structure determined to a resolution of 8 angstrom in the membrane plane. When considered together with the large body of biochemical information that has been accumulated for this transporter, and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by this enzyme.     

Localization for the Non-Invasive Detecting Capsule in GI Tract Utilizing Permanent Magnet and Magnetoresistive Sensors

The paper reports the localization principle and method for the capsule in the non-invasive detecting system of gastrointestinal (GI) tract utilizing one permanent and three magnetoresistive sensors. When the capsule is localized in practice, the permanent magnet is fixed inside the capsule, and the four magnetoresistive sensors are installed outside body. The permanent magnet's coordinate values can be solved by the magnetic dipole theory and optimum iterated method. The experiment shows the localization distance can reach 300 mm by employing the HMCI023 magnetoresistive sensors and the NdFeB45 φ9 mm × 5 mm permanent magnet, and the errors of single coordinate direction and radius vector are 0 - 58 mm and 0.1-62.9 mm respectively. The localization precision is acceptable basically, and it has some possibilities improving the precision and distance in the future. Moreover, the localization system makes the localization be reality because of decreasing the number of sensors, and it economizes the capsule's volume because of decreasing the permanent magnet's dimension, too.