Coordinate Properties of Nitric Oxide in Hemoglobin Solution Containing a Minimal Amount of Nitric Oxide

ＩｎｔｒｏｄｕｃｔｉｏｎＮｉｔｒｉｃｏｘｉｄｅ(ＮＯ)ｕｓｅｄｔｏｂｅｒｅｇａｒｄｅｄｏｎｌｙａｓａｔｏｘｉｃｇａｓｍｏｌｅｃｕｌｅ .Ｎｏｗｉｔ ｐｒｏｖｅｓｔｈａｔＮＯｉｓａｍｅｓｓｅｎｇｅｒｉｎｂｉｏｌｏｇｉｃａｌｓｙｓｔｅｍａｔｉｃｓｉｇｎａｌｔｒａｎｓｄｕｃｔｉｏｎｃａｓｃａｄｅｓａｎｄｉｔｉｓｔｈｅｕｎｉｑｕｅ ｇａｓｓｉｇｎａｌｍｏｌｅｃｕｌｅ ,ｌｅａｄｉｎｇｔｏｎｕｍｅｒｏｕｓｂｉｏｃｈｅｍｉｃａｌ,ｃｅｌｌｕｌａｒ ,ａｎｄｐｈｙｓｉｏｌｏｇｉｃａｌｒｅｓｐｏｎｓｅｓ .Ｅｓｐｅｃｉａｌ…     

我国运输质量的总体评价

建立了评价运输质量的指标体系,并以世界主要国家为标准,评价了目前我国运输质量已达到的水平及在国际上所处的位次,为提高我国运输质量提供了依据。     

骆驼蓬属主分量及模糊聚类分析

应用主分量和模糊聚类方法对国产骆驼蓬属进行了分类,验证其经典分类结果,并揭示其主要性状之间的内在联系及各性状所占有信息比例     

KPCA与LTSA融合的转子故障数据集降维算法

针对核主成分分析(kernel principal component analysis,KPCA)和局部切空间排列算法(local tangent space,LTSA)在降维过程中无法兼顾保持数据全局结构特性和局部结构特性的问题,利用核函数的可线性叠加性质,提出一种将KPCA算法与LTSA算法融合的非线性降维算法....     

SPR生物传感系统研究

对自行研制的SPR生物传感系统各部分给出了详细描述.系统采用独特的角向会聚光路代替传统的角度机械扫描方式,采用CCD作为光电检测器件,避免了机械扫描可能带来的误差,可一次完成样品响应曲线的采集分析,提高了检测精度和速度.此外,利用M ATLAB软件对信号进行了F IR滤波分析处理,提高了信噪比.测试表明,系统的分辨率为3.59×1-0 5R IU,灵敏度为98.61度/R IU,检测范围为1.00~1.47 R IU.     

具共振条件的二阶四点边值问题解的存在性

考虑一类二阶边值问题．应用Mawhin重合度理论,在适当条件下,给出了共振情况的解的存在性结果．     

EEG动力学模型中随机共振现象的仿真研究

脑电图(electroencephalogram,EEG)中随机共振现象的研究对于分析大脑系统的行为具有重要理论意义和应用价值.为了模拟大脑系统中检测信号的机制,提出使用信噪比、互相关系数、互信息率对比评价方法,对EEG动力学模型中随机共振现象进行了研究.实验结果表明,EEG动力学模型不但存在着周期随机共振现象,同时也存在着非周期随机共振现象.此研究为大脑系统中存在着随机共振现象的观点提供了一种新的证据.     

Structural biology of protein tyrosine kinases

Our current understanding of the structure, mechanism of action and modes of regulation of the protein tyrosine kinase family owes a great deal to structural biology. Structures are now available for more than 20 different tyrosine kinase domains, many of these in multiple conformational states. They form the basis for the design of experiments to further investigate the role of different structural elements in the normal function and regulation of the protein and in the pathogenesis of many human diseases. Once thought to be too similar to be specifically inhibited by a small molecule, structural differences between kinases allow the design of compounds which inhibit only an acceptable few. This review gives a general overview of protein tyrosine kinase structural biology, including a discussion of the strengths and limitations of the investigative methods involved. Received 2 May 2006; received after revision 21 June 2006; accepted 9 August 2006     

Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects

Using surface plasmon resonance (SPR) and electrospray mass spectrometry (ESI-MS), proinsulin C-peptide was found to influence insulin-insulin interactions. In SPR with chip-bound insulin, C-peptide mixed with analyte insulin increased the binding, while alone C-peptide did not. A control peptide with the same residues in random sequence had little effect. In ESI-MS, C-peptide lowered the presence of insulin hexamer. The data suggest that C-peptide promotes insulin disaggregation. Insulin/insulin oligomer μM dissociation constants were determined. Compatible with these findings, type 1 diabetic patients receiving insulin and C-peptide developed 66% more stimulation of glucose metabolism than when given insulin alone. A role of C-peptide in promoting insulin disaggregation may be important physiologically during exocytosis of pancreatic β-cell secretory granulae and pharmacologically at insulin injection sites. It is compatible with the normal co-release of C-peptide and insulin and may contribute to the beneficial effect of C-peptide and insulin replacement in type 1 diabetics. Received 3 May 2006; received after revision 9 June 2006; accepted 12 June 2006 Free Online Access     

道德风险与基于委托-代理理论的最优保险契约模型

分别针对事后信息对称和存在道德风险的情况 ,使用委托—代理理论建立了相应的保险契约分析模型 ,对两种情况下的最优保险契约的性质进行了研究 .我们证明了信息对称时 ,最优保险契约要求完全保险 ,从而可以达到帕累托最优的风险分担 ,而且此时最优保险费等于意外事件造成损失的期望值 ;存在道德风险时 ,出于激励的目的 ,最优保险契约要求只提供部分保险 ,最优保险费小于意外事件造成的期望损失 ,而且随着意外事件造成损失的增大 ,投保人所遭受的实际损失也应该增大 .在两种情况下 ,最优保险费都与投保财产成反比.