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41.
Summary Bacterial mutagenicity assay to detect potential chronic toxicity of a potent, new, benzoyl urea insect growth regulator (CGA-112913 or IKI-7899, formerly UC-62644) was conducted using 5 histidine auxotrophs ofSalmonella typhimurium. Tests within the concentration range of 0.9–500 g (saturating)/plate of the compound with and without the 5–9 mammalian metabolic activation system showed no mutagenic effects clearing the way for long-term chronic toxicology studies.The authors thank Professor Bruce N. Ames for supplying the tester strains together with all the relevant information for conducting the bioassays and Ms. Norma Charlebois for her meticulous technical assistance. 相似文献
42.
M. Kashimata M. Hiramatsu N. Minami Jr N. Minami 《Cellular and molecular life sciences : CMLS》1987,43(2):191-192
Summary An enzyme immunoassay for mouse epidermal growth factor (EGF) involving a liquid phase double-antibody system was developed. The EGF--galactosidase conjugate prepared was stable for at least 8 months. By this method, EGF was detectable at a concentration as low as 20 pg per tube. The concentrations of EGF in various tissues of mice are also presented.This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. 相似文献
43.
研究带有均值回复Ornstein-Uhlenbeck过程的随机logistic种群模型的动力学行为。证明收获努力E*可以控制随机微分方程模型的随机灭绝和持续:若E≥E*并且满足一些其他条件,则种群灭绝;若E 相似文献
44.
含铝高速钢中奥氏体非均匀长大的机制 总被引:2,自引:0,他引:2
M2AI和M2高速钢经一次和二次淬火后,奥氏体晶粒和未溶碳化物的定量研究表明,在高温r/f比值相同的条件下,由于淬火前原始组织的差别,可发生正常(均匀)和异常(非均匀)两类长大。根据异常粗晶形成初期的组织观察,提出了“连续-非连续”再结晶模式和“合并—推移”式的生长机制。提出了减轻或消除M2AI钢混晶的工艺原则。 相似文献
45.
刘金河 《厦门大学学报(自然科学版)》1990,29(4):472-474
不同组合巴西橡胶三合树在福建南部的生态条件下,其生长强度,生理代谢和抗逆能力都存在差异。本文中主要研究比较了几种橡胶三合树的生长强度,光合作用强度及其变化。研究结果表明,三合树的生长强度和光合强度明显比对照树高,不同组合三合树的生长强度和光合强度与它们的抗寒力成正相关。 相似文献
46.
H. Tsuchiya M. Sato M. Iinuma J. Yokoyama M. Ohyama T. Tanaka I. Takase I. Namikawa 《Cellular and molecular life sciences : CMLS》1994,50(9):846-849
Phytoalexins, defensive compounds produced by plants against microbial infections, were purified fromSophora exigua (Leguminosae) and their growth inhibitory effects on oral cariogenic bacteria were determined in vitro. Among three isolated compounds, 5,7,2,4-tetrahydroxy-8-lavandulylflavanone completely inhibited the growth of oral bacteria including primary cariogenic mutans streptococci, other oral streptococci, actinomycetes, and lactobacilli, at concentrations of 1.56 to 6.25 g/ml. 相似文献
47.
A. M. Fenyves M. Saxer K. Spanel-Borowski 《Cellular and molecular life sciences : CMLS》1994,50(2):99-104
Five cell types recently isolated from the bovine corpus luteum differed in their epithelioid morphology and their cytoskeleton, but shared common criteria of microvascular endothelial cells1,2. To give strong evidence for the separate entity, the growth rate of the 5 phenotypically different cells was studied. They were seeded at low density on day 0. Most of these cells were treated with 200 to 1000 U recombinant bovine interferon- (IFN-) for 3 days. The untreated remainder served as controls. Cell counts were made for all cultures on days 4, 7, 10 and 13. morphology: 13 d after treatment with IFN- senescent cells as well as intact cells occurred in cultures of cell types 1 to 4. Cultures of cell type 5 were apparently unchanged and resembled their untreated counterparts. Desminpositive cells in cultures of cell type 2 developed cell processes. Growth rate: In the absence of IFN-, the growth rate was high for cell types 3 and 4, moderate for cell type 1, and low for cell types 2 and 5. The presence of IFN- caused anti-proliferative effects. These were higher for cell types 3 and 4 than for cell types 1 and 2. IFN- could be cytotoxic on cell type 3. In contrast, the cytokine tended to support the cell growth of cell type 5. These findings substantiate the postulate that endothelial cells exhibiting separate morphology in culture also function differently. 相似文献
48.
Bryozoans are common, often abundant, sessile, colonial invertebrates of freshwaters. By reviewing what is known of their general ecology and considering in further detail the population biology of specific groups, we provide evidence that 1) populations are locally ephemeral and regional persistence is attained via a dynamic equilibrium between dispersal and colonization, and 2) sex may often be infrequent and a high degree of clonality obtains at both local and regional scales. On the basis of these characteristics we discuss how the group offers exceptional opportunities for investigating a number of fundamentally important ecological and evolutionary questions.The highly curious modification of the Molluscan type which the Polyzoa [=Bryozoa] present... the great beauty of their forms, and the facility with which they can in general be observed in a living state, cannot but render them special favorites for every lover of Nature; and for the more profound student must confer on them a peculiar significance, and invest their study with a scientific interest which is scarcely surpassed by that of any other group of animals.... (Allman 1856) 相似文献
49.
Thrombospondin (TSP) is a multifunctional glycoprotein which is synthesised by several cell types including osteoblasts, and incorporated into the extracellular matrix (ECM) of these cells. The function and regulation of TSP in bone is not clear. In this study, using a long term culture model of human osteoblast-like cells, we examined the distribution of TSP in the ECM and its modulation by added estradiol. In this model the osteoblast-like cells form a regular multilayer which continues to increase in depth up to 50 days post confluence. In the ECM of these cultures and in 19-week fetal bone, the bone markers osteocalcin and alkaline phosphatase were diffusely distributed in the matrix. In contrast, labelling for TSP was concentrated, confined to the banded collagen and its immediately adjacent ECM. This pattern of labelling resembled that of the growth factors transforming growth factor-I (TGF), and insulin-like growth factor-I (IGF-I), with which TSP label co-localised. Labelling intensities were comparable between fetal bone and the in vitro material for TSP, TGF and IGF-I. TSP label was present by 10 days post confluence, reached a maximum by 20 days, and declined slowly thereafter, a time course which was similar to that of IGF-I. Incubation of osteoblast-like cell cultures with 17 estradiol resulted in an increase in multilayer depth and a maximal 3-fold increase in TSP labeling at 30 days as well as approximately 2-fold increases for TGF and IGF-I. The dose-response relationship for these responses to estradiol treatment was biphasic with maximal increases at 10–10 M–10–11 M of added estradiol. Treatment with 17 estradiol produced labelling intensities that were not significantly different from controls. Studies with other cell types have suggested that TSP may be involved in modulation of growth factor activity. The similarities between TSP, TGF and IGF-I, in terms of their distribution and regulation by 17 estradiol treatment, may indicate a role for TSP in modulating bone cell proliferation and function through interaction with local growth factors. 相似文献
50.