玻璃电极作为内导的PVC膜苯海索离子电极研制

以玻璃电极为内参比电极直接涂覆活性材料研制成功PVC膜盐酸苯海索离子选择性电极,盐酸苯海索含量在10^-5～10^-2mol／L时电极有能斯特响应,电极有较好的稳定性与重现性,用校准曲线法测得药片中盐酸苯海索含量为每片1．730mg(n=5),相对标准偏差为4．0％,并以苯海索电极为指示电极,四苯硼钠电位滴定法对同一样品进行了测定,得到了一致的分析结果。     

盐酸西替利嗪在CDMPC手性柱上的对映体分离

盐酸西替利嗪是第二代抗组胺药,具有旋光性,其中右旋西替立嗪无抗组胺作用.利用CDMPC手性固定相,在高效液相色谱上对盐酸西替利嗪进行了对映体分离研究,考察了醇类添加剂种类及含量对其对映体分离的影响.     

青防肿痛外敷散局部组织药动学研究

研究外用给药制剂盐酸青藤外敷散多次给药后有效成分盐酸青藤碱在实验大鼠局部组织的药代动力学,探索其在局部给药系统中的药动学行为.对实验大鼠后足造模并贴敷给药后,测定大鼠给药足组织内盐酸青藤碱的吸收量,并用PKSolver药动学软件进行药动学参数的计算与曲线的拟合.药动学参数Lambda_z、Vz/F_obs、Tmax、Css、DF%值分别为0.14 d-1、5.64 m L/mg、2 d、0.24 mg/m L、75%.从药动学数据可知药物在局部组织中含量较高,局部患处在高质量浓度的药物作用下,可达到较好的治疗效果,且外用局部给药可减少全身用药的不良反应,耐受性良好.     

黄连中盐酸小檗碱不同提取工艺的比较研究

以黄连中盐酸小檗碱的提取效率和纯度为指标,对乙醇回流浸提法、硫酸常温浸提法和超声波辅助萃取法进行比较．结果发现乙醇回流浸提法、硫酸常温浸提法及分别以乙醇、硫酸为溶剂的超声波辅助萃取法的提取率为2．7％、2．6％、3．1％和3．5％,产品纯度为79．01％、89．81％、85．21％和95．91％．超声波辅助萃取法具有简便快速和节能高效的优点,是一种值得在工业上推广的提取新工艺．     

Rheological Behavior of the Guanidio Polyelectrolytes

The rheological behavior of polyhexamethylene guanidine hydrochloride (PHGC) and polyhexamethylene guanidine stearate (PHGS) has been investigated using the capillary rheometer. It is shown that the polyelectrolyte melts are non-Newtonian of shear-thinning fluid. The melt viscosity, die flow activation energy and the flow temperature are high even if the molecular weight is not high. The melting viscosity of PHGC is higher than that of PHGS at the same experimental conditions. By comparison with the case of PHGS the non-Newtonian index of PHGC is smaller, the flow activation energy and die flow temperature of PHGC are higher, which was caused by the difference in their molecular structure.     

荧光分光光度法测定小檗碱的含量

用荧光分光光度法测定药品中小檗碱含量,荧光检测波长,Ex=360nm,Em=414nm,工作曲线线性范围0.832~3.328mg/mL.实验选用两种药品测定其含量,在盐酸小檗碱片中回收率为98.37%(RSD=0.3%),在复方黄连素片为98.04%(RSD=0.5%).     

Enhanced photocatalytic degradation of tetracycline hydrochloride by molecular imprinted film modified TiO<Subscript>2</Subscript> nanotubes

To enhance the photocatalytic activity of TiO2 nanotubes,tetracycline hydrochloride(TC) molecularly imprinted titania modified TiO2 nanotubes(MIP-TiO2) was prepared by liquid phase deposition,which improved the molecular recognition ability of the photocatalyst toward template molecules.This MIP-TiO2 photocatalyst was characterized by ESEM and XRD,which showed that the imprinted titania was deposited on the nanotube uniformly and was of well-crystalized anatase-type.In the adsorption experiments,MIP-TiO2 exhibited a high adsorption capacity(about 1.6 times higher than that of TiO2 nanotubes) for TC mainly because of its imprinted sites and high surface area.Under UV irradiation MIP-TiO2 showed enhanced photocatalytic activity with an apparent first-order rate constant 1.9-fold that of TiO 2 nanotubes.     

苯三甲酸和盐酸胍为主体晶格管状包合物的晶体结构

合成了苯三甲酸和盐酸胍共同构建主体晶格的正四丁基铵阳离子管状包合物(C4H9)4N+·2C(NH2)+3·1,3,5-C6H3(COO-)3·3H2O,并通过单晶X射线衍射法对其进行了晶体结构测定。结果表明:包合物中苯三甲酸阴离子和盐酸胍阳离子氢键连接形成的宽链借助水分子氢键连接在一起,形成沿bc平面无限延伸的二维氢键褶皱层,构成类长方形管道的一对管壁,另一盐酸胍阳离子穿插在氢键层中,构成管道的另一对管壁,每个管道内包含两列规则排列的正四丁基铵阳离子(n-C4H9)4N+。     

盐酸沙格雷酯有机溶剂残留量的GC法测定

为了建立气相色谱法测定盐酸沙格雷酯中丙酮、乙醇、四氢呋喃、乙腈、甲苯5种有机溶剂残留的方法,采用内壁涂有PEG-20M的毛细管柱为色谱柱,氢火焰离子化(FID)检测器为检测器,载气为氮气,柱温70℃,汽化室150℃,检测器250℃.在以上色谱条件下,丙酮、乙醇、四氢呋喃、乙腈、甲苯均能得到良好的分离,溶剂对测定无影响,在测试浓度范围内,峰面积与浓度线性关系良好(r>0.991),进样精密度实验的RSD值均小于5.0%,丙酮、乙醇、四氢呋喃、乙腈、甲苯最低检测限分别为0.3μg/mL、0.4μg/mL、0.2μg/mL、0.4μg/mL、0.9μg/mL.本方法简单、准确、灵敏度高,重现性好,可用于该药的有机溶剂残留的测定.     

盐酸吗啡片含量的荷移光谱法测定

研究了吗啡与7,7,8,8 四氰基对二次甲基苯醌(TCNQ)的荷移反应,对反应条件进行了优化.在丙酮介质中,二者在30℃中30min即可形成荷移络合物,分别在743和840nm处有较强光吸收,吗啡浓度在0.5～9和0.6～9μg·mL-1范围内符合比尔定律,其表观摩尔吸光系数分别在1.1×104及1.4×104,方法的相对标准偏差为1.8%(n=9).