胎盘早剥13例临床分析

目的：探讨胎盘早剥的发生规律，诊治特点及预后。方法；对延安大学医学院附属医院1997－2001年6月间13例胎盘早剥进行研究。结果：胎盘早剥起病急，发展快，如果诊断处理不及时会严重母婴生命。结论：胎盘早剥诊断的迟早，处理及否及时与母婴预后密切相关。     

过期妊娠胎盘绒毛的初步体视学研究

用英国Ｃａｍｂｒｉｄｇｅｑｕａｎｔｉｍｅｔ５２０（＋）［Ｑ５２０（＋）］图像分析仪分别对４０、４１、４２周各８例胎盘绒毛进行初步体视学研究，测定其结构参数并计算其密度参数，形状参数及分布参数，所得各组结果虽然不同，但其组间差异并无显著性（Ｐ＞０．０５），提示过期妊娠与足月妊娠相比．胎盘绒毛本身形态定量变化只是程度不同，无明显界线。在观察了３组胎盘绒毛内部结构的病理变化基础上，发现过期妊娠并发症与绒毛本身定量的形态改变并无直接关系，而可能与绒毛内部结构的形态变化有关。     

以人为本和与自然共生的医院建筑设计

针对医疗设施的载体当代医院建筑空间环境设计，从以人为本和与自然共生的设计思想出发，详细论述了医院空间环境的人性化与家庭化的设计；积极应用高新技术。注重医院空间环境创造中的高技术与高情感的平衡；满足高品质、高效率的服务；以及医院建筑空间与自然结合；达到节能、节地与可持续发展。     

Morphofunctional changes in the mitochondrial subpopulations of conceptus tissues during the placentation process

To establish the role of mitochondrial subpopulations in the mitochondrial maturation process, we studied morphological and functional changes in the mitochondria of different mammalian conceptus tissues during the organogenic and the placentation processes. Mitochondrial subpopulations of three different conceptus tissues, embryo and visceral yolk sac placenta on gestational days 11, 12 and 13 and placenta on days 12 and 13, were examined morphologically by transmission electron microscopy. Cytochrome oxidase activity and protein levels were also measured in each mitochondrial subpopulation. The results indicate two different mitochondrial subpopulation profiles: a homogeneous one, which corresponds to immature mitochondria, and a heterogeneous one, which represents the mature mitochondria. The three tissues studied show different morphologic and metabolic patterns of mitochondrial maturation during the placentation process, rendering them suitable as experimental models to establish the p ossible relationship between mitochondrial maturation and the mitochondrial subpopulations. Received 5 August 2002; received after revision 23 September 2002; accepted 8 October 2002 RID="*" ID="*"Corresponding author.     

Localization and possible role of membrane type metallo-proteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation

Human placental tissues from the first and second trimesters of gestation have been investigated using riboprobein situ hybridisation of mRNA sequences coding for membrane type metalloproteinase (MT-1-MMP) and tissue inhibitors of metalloproteinase-1 (TIMP-1). Results show that (i) both mRNAs express at a relatively high level in the chorion laeve trophoblast cells and the adjacent decidual cells of fetal membrane; (ii) the most abundant expression of the two mRNAs was found in the extravillous trophoblast between Rohrs and Nitabuch striae of basal plate, trophoblast shell and gland cells of the decidua; (iii) isolated or small groups of cytotrophoblast cells in the chorionic villi and in the cells lining arterioles in decidua and stem villi also expressed both MT-1-MMP and TIMP-1 at defferent extents. The data suggest that the coordinated expression of the MT-MMP and its inhibitor TIMP in defferent cells of the placental tissue may play an essential role in trophoblast invasion and angiogenesis related to placentation in the first two trimesters of gestation. They may also have an ability to effect separation of fetal from material tissue at a favorable junctional site during parturition.     

核糖核酸酶抑制因子的制备及急性毒性实验

对新鲜人胎盘进行硫酸铁分级沉淀，透析，DEAE-纤维素-23离子交换层析，制取初步纯化的核糖核酸酶抑制因子（RI）．小鼠急性毒性实验结果表明，RI对小鼠没有急性毒性．     

一种判别雌蕊结构中胎座类型的方法

在鉴别被子植物种类的过程中,准确地书写植物花程式和判别胎座类型是学生必须掌握的基本实验技能。文章从胎座类型、雌蕊类型及其子房结构组成之间的相互关系入手,介绍了一种快速、简便、准确判别雌蕊结构中胎座类型的实验方法和操作流程。     

胎盘促肾上腺皮质激素释放激素研究进展

回顾了关于胎盘促肾上腺皮质激素释放激素研究的最新进展，其内容包括ｐＣＲＨ的合成与分泌、ｐＣＲＨ释放的调节、孕妇血浆ＣＲＨ水平的变化及其对ＨＰＡ轴活动的影响以及ｐＣＲＨ的生物学作用等。作者认为，进一步阐明ｐＣＲＨ的旁分泌，自分泌和长距分泌作用将助于理解妊娠维持，胎儿发育和分娩启动等生理机制。     

乙醇对人工流产新鲜绒毛雌二醇分泌的影响

本工作利用体外灌输技术,观察了三种不同浓度的乙醇(1％,2.5％、5％)对妊娠早期人工流产新鲜胎盘绒毛分泌雌二醇的影响。结果表明,乙醇具有促进雌二醇分泌的作用,但在乙醇剂量和雌二醇水平之间不存在正相关性。提示妊娠妇女经常饮酒或酗酒可能通过破坏胎盘激素内分泌的平衡,从而影响胎儿的正常生长和发育。     

活化羊胎素的提取与应用开发

以健康羊胎盘为原料,采用现代生物工程技术制备活化羊胎素制备工艺简单,无需特殊提纯手段。研究表明,其活性成分能显著地机体免疫能力。