高密度电法的延时性勘探研究

描述了高密度电阻率法延时性勘探的基本思想,对矿山排土场进行高密度电阻率法延时性的实际勘探.对比高密度电阻率法延时性勘探的成果资料,对电阻率随时间的变化进行工程与环境解释.结果表明高密度电阻率法延时性勘探对于解决未饱和区域水的流动、水位的变化、化学污染物的扩张和堤坝的渗漏等具有较高的准确性.     

平滑算子在地震叠前深度域成像中的应用

对波动方程叠前深度偏移的成像条件和平滑算子进行了概述,推导了用平滑算子对成像条件进行平滑的公式,给出了同一平滑函数在不同平滑参数控制下以及不同平滑函数在相同平滑参数控制下的成像结果.模型试算结果表明:在合适的平滑参数控制下,平滑后的成像结果得到了明显改善;在相同的平滑参数控制下,Gaussian窗平滑算子平滑后得到的成像结果要好.     

阿贝成像原理中"分频、合频"的实验演示

在阿贝成像原理的教学过程中,通过实验演示物体成像的分频和合频过程,使学生更容易理解阿贝成像的本质就是两次傅里叶变换,同时对空间频谱、分频、合频等概念更容易掌握,也为空间滤波的学习打下基础.     

SAR实时成像系统的快速定点仿真验证技术

SAR实时成像处理系统的定点化优化能够减小系统存储规模、提高系统运算速度,是降低系统功耗、减小系统规模、提高实时性的有效方法.本文以CS成像算法为例,分析并统计了算法的运算量,针对其核心运算--FFT进行了定点化优化,选择基-22FFT算法,设计了合理的定标策略.采用SystemC语言对整个SAR成像系统进行了系统级快速仿真和验证,真实模拟了FPGA系统的实现结果.对16 384×16 384大小的点阵数据和面目标数据采用24 bits的字长进行了成像仿真,仿真结果满足系统指标要求.      

纳米稀土金属有机框架材料的合成及其生物医学应用研究进展

近年来,纳米稀土金属有机框架(MOF)材料的合成及其在生物医学,特别是在肿瘤诊断和治疗方面的应用研究引起了科学家们广泛的关注.一方面,纳米稀土MOF具有独特的光学和磁学性质,可用于生物成像(如荧光成像和磁共振成像等);另一方面,纳米稀土MOF的组成和结构多样,且具有高的比表面和大的孔容,是具有潜力的药物控释载体.这种集多种功能于一身的纳米稀土MOF为开发新型的诊疗一体化试剂提供了一个新的平台.介绍了近年来纳米稀土MOF的合成及其在生物医学方面的应用的研究进展.     

基于计算机图形学的干涉SAR成像几何仿真

为了提高干涉sAR成像几何经典仿真算法的精度和效率,把计算机图形学引入干涉SAR成像几何仿真中,利用OpenGL图形库和Z缓冲算法来完成目标的阴影区计算,利用像素操作和图形变换法完成目标采样点的插值和坐标计算.最后,利用典型几何体和不同大小场景进行干涉成像几何仿真精度和效率的分析,结果表明该方法具有高精度、高效率的特点.     

Destruction geodynamics of the North China craton and its Paleoproterozoic plate tectonics

Much attention has been paid in the last two decades to the physical and chemical processes as well as temporal-spatial variations of the lithospheric mantle beneath the North China Craton. In order to provide insights into the geodynamics of this variation, it is necessary to thoroughly study the state and structure of the lithospheric crust and mantle of the North China Craton and its adjacent regions as an integrated unit. Based on the velocity structure of the crust and upper mantle constrained from seismological studies, this paper presents various available geophysical results regarding the lithosphere thickness, the nature of crust-mantle boundary, the upper mantle structure and deformation characteristics as well as their tectonic features and evolution systematics. Combined with the obtained data from petrology and geochemistry, a mantle flow model is proposed for the tectonic evolution of the North China Craton during the Mesozoic-Cenozoic. We suggest that subduction of the Pacific plate made the mantle underneath the eastern Asian continent unstable and able to flow faster. Such a regional mantle flow system would cause an elevation of melt/fluid content in the upper mantle of the North China Craton and the lithospheric softening, which, subsequently resulted in destruction of the North China Craton in different ways of delamination and thermal erosion in Yanshan, Taihang Mountains and the Tan-Lu Fault zone. Multiple lines of evidence recorded in the crust of the North China Craton, such as the amalgamation of the Archean eastern and western blocks, the subduction of Paleo-oceanic crust and Paleo-continental residue, indicate that the Earth in the Paleoproterozoic had already evolved into the plate tectonic system similar to the present plate tectonics.     

mRNA detection in living cell using phosphorothioate-modified molecular beacon

In this study, GFP mRNA in COS-7 cell and GFP-transfected COS-7 cell was detected in real time using phosphorothioate-modified molecular beacon based on living cell imaging method. Results showed that phosphorothioate-modified molecular beacon still kept the advantages of molecular beacon, such as, excellent selectivity, high sensitivity, and no separation detection. In addition, this modification could significantly increase the nuclease resistance of molecular beacon. Phosphorothioate-modified molecular beacon can efficiently reduce the false positive signal and improve the accuracy of living cell mRNA detection. Supported by the National Key Basic Research Program (Grant No. 2002CB513110), International Technologies Collaboration Program of China (Grant No. 2003DF000039), and National Natural Science Foundation of China (Grant Nos. 90606003 and 20620120107)     

The preparation and application of microbubble contrast agent combining ultrasound imaging and magnetic resonance imaging

Encapsulated gas microbubbles are well known as ultrasound contrast agents （UCAs） for medical ultrasound （US） imaging. With the development of shell materials and preparation technologies, the application of microbubbles has been enormously popular in molecular imaging, drug delivery and targeted therapy, etc. The objective of this study is to develop Fe3O4 nanoparticle-inclusion microbubble construct. The in vitro US imaging experiment indicates that the Fe3O4 nanoparticle-inclusion microbubbles have higher US enhancement than those without Fe3O4 nanoparticle-inclusion. According to the microbubble dynamic theory, the acoustic scattering properties can be quantified by scattering cross-section of the shell. The scattering study on Fe3O4 nanoparticle-inclusion microbubbles of different concentration shows that within a certain range of concentration, the scattering cross-section of microbubble increases with the addition of Fe3O4 nanoparticles. When exceeding the concentration range, the ultrasonic characteristic of microbubbles is damped. On the other hand, since Fe3O4 nanoparticles can also serve as the Magnetic Resonance Imaging （MRI） contrast agent, they can be potentially used as contrast agents for the double-modality （MRI and US） clinical studies. However, it is important to control the concentration of Fe3O4 nanoparticles in the shell in order to realize the combined functions of US and MRI.     

MRIgHIFU治疗的热损伤阈值研究

研究基于磁共振T-Map的等效热剂量积分法监控高强度聚焦超声治疗的可行性.并筛选出高强度聚焦超声损伤组织的热剂量阈值.运用磁共振导航高强度聚焦超声治疗系统,使用1 MHz、焦距为150 mm、直径150 mm的聚焦超声换能器,用不同辐照声功率和辐照时间定点辐照深度为20 mm的新鲜离体牛肝脏,辐照过程中用磁共振的测温序列采集各体素随时间变化的温度值并计算各体素的Eq43值,比较计算结果与发生凝固性坏死的Eq43参考阈值,判断该体素是否发生坏死,得到发生凝固性坏死的热剂量区域轮廓和面积.辐照结束后沿凝固性坏死最大面剖开牛肝组织,测量凝固性坏死的面积.选择不同的Eq43参考阈值,并将热剂量计算得到的坏死面积与实际坏死面积进行比较.筛选出离体牛肝组织发生凝固性坏死的最佳热剂量参考阈值.结果表明,基于磁共振T-Map的等效热剂量积分法得到的凝固性坏死的面积值能很好地反应实际发生凝固性坏死的情况,当Eq43参考阈值选为31.2 min时,各辐照声功率和辐照时间下两者大小均无统计学差异.热剂量法为HIFU治疗提供了一种新的判断凝固性坏死发生的方法,这种方法可以实时地反馈控制超声辐照剂量,提高了治疗的安全性和有效性.