笠贝幼虫变态相关基因筛选及分子网络构建

利用NCBI在线数字化差异显示工具（Digital Differential Display）对笠贝(Lottia gigantea)EST数据库进行筛选,获得笠贝幼虫时期显著差异表达基因203个,其中124个基因有Blast2Go注释结果,这124个基因可以归类成细胞组分、分子功能和生物学过程三大类;参与MAPK、Ras、PI3K-Akt、Rap1、cAMP等信号通路;涉及能量代谢、免疫应激、细胞分化、神经发育、细胞骨架、信号传递等生物学过程.将获得的转录子运用Cytoscape软件构建分子相互作用网络,最终获得7个核心转录子.涉及到神经发育、次生壳形成等相关基因调控关系.     

一种基于CUDA的局部敏感哈希算法

传统的局部敏感哈希算法建立哈希表时往往需要较大的内存空间以及较长的建立时间. 在查询阶段,查询样本K个最近邻数据项的所需时间超过整个运行时间的95%. 针对这些问题,运用计算设备架构将局部敏感哈希算法移植至图形处理器,并用多线程并行计算数据项的哈希值来建立哈希表. 查询阶段在全局内存中引入基于工作队列的多样本查询,以提高算法的运行效率. 实验结果表明,所提出的算法与传统的局部敏感哈希算法相比,能在不降低运算精度的情况下将运算速度提高近12倍.     

癌症基因表达数据的熵度量分类方法

基因芯片技术的出现和发展为生物医学领域带来了深远影响,运用分类方法研究其产生的海量数据对癌症的分类及治疗有重要意义.该文提出一种利用熵度量作为指标进行癌症基因表达数据特征提取的方法.首先对基因表达数据进行筛选并计算各个基因的熵,然后提取出熵最大的若干基因作为特征基因,并用支持向量机进行分类.对前列腺癌基因表达数据的留一法以及分组法实验都证明了该方法的有效性.     

电磁干扰下的电爆装置射频敏感频率研究

针对电爆装置在电磁辐射干扰下的射频敏感频率,提出采用场线耦合理论进行分析.建立了电爆装置的传输线模型,推导得到电爆装置吸收功率与入射频率之间的数学表达式,通过数值仿真的方法研究了敏感频率的影响因素.仿真结果表明,电爆装置的脚线长度决定敏感频率;脚线等长而连接方式不同的电爆装置射频敏感频率相同.研究结果可以为电爆装置的射频危害分析提供理论参考.     

拟南芥温敏雄性不育突变体atms1的获得及表型分析

从甲基磺酸乙酯（ethylmethane sulfonate,EMS）化学诱变建立的野生型拟南芥（Col-0）突变体文库中筛选到1株突变体.在低温16 ℃时,该突变体的雄性育性与野生型没有显著差异,花粉染色呈现100%可育.随着培养环境温度的升高,突变体花粉育性逐渐下降,因此,该突变体为一温敏雄性不育突变体,并被命名为atms1（ambient temperature-sensory male sterility 1,即环境温度敏感雄性不育1）.花药切片结果显示,在23 ℃以下,该突变体花药各个发育时期的形态与野生型花药没有显著的差异;而27 ℃处理1周后的突变体花药呈现多种表型：同一朵花中各个花药的发育时期出现显著分化,花粉母细胞胼胝体单薄,绒毡层发育滞后于同时期的野生型花药.遗传分析确定,atms1的不育表型是由单个隐性核基因控制的.     

不同体育选项课对大学男生体质健康指数影响的比较分析

根据教育部、国家体育总局制定的《学生体质健康标准和实施办法》,对大庆石油学院和黑龙江八一农垦大学不同体育选项课大学男生体质健康指数变化进行比较研究,为解决体育自主选项课存在的问题提供数据支持与理论方法。     

Immunological determinants of the outcomes from primary hepatitis C infection

Individuals infected with hepatitis C virus (HCV) have two possible outcomes of infection, clearance or persistent infection, determined by a complex set of virus-host interactions. The focus of this review is the host mechanisms that facilitate clearance. Strong evidence points to characteristics of the cellular immune response as the key determinants of outcome, with evidence for the coordinated effects of the timing, magnitude, and breadth, as well as the intra-hepatic localisation of CD4+ and CD8+ T cell responses being critical. The recent discovery of viral evasion strategies targeting innate immunity suggests that interferon-stimulated gene products are also important. A growing body of evidence has implicated polymorphisms in both innate and adaptive immune response genes as determinants of viral clearance in individuals with acute HCV. Received 16 May 2008; received after revision 07 September 2008; accepted 30 September 2008     

The Alpha Thalassaemias

Recent work in the α thalassaemia field has started to provide some indication of the mechanisms involved in the very high frequency of the different forms of α thalassaemia among the populations of tropical countries, and, at the same time, is starting to define at least some of the mechanisms for its remarkable phenotypic heterogeneity. These diseases continue to provide extremely valuable models for the better understanding of the regulation of the α globin genes, and for human molecular pathology in general. The much less common disorders, ATR-16 and ATR-X are also providing valuable information about the spectrum of molecular lesions associated with different forms of mental retardation and about the molecular mechanisms involved in their varying phenotypes. Received 29 August 2008; received after revision 07 October 2008; accepted 14 October 2008     

WO3基燃气敏感元件的研制

在三氧化钨粉体材料中加入4 wt%瓷粉,以恒温600℃烧结1 h制成旁热式厚膜可燃性气体敏感元件.采用静态电压测量法,研究了元件的加热功率与元件灵敏度的关系,讨论了元件的响应与恢复特性.实验结果显示:WO3基元件在加热功率为600 mW时能开发成理想的乙醇、丙酮和汽油敏感元件.