PTC转移非解离型中性分子的研究 Ⅰ.催化剂结构与氰化亚铜分子的萃取

研究了相转移催化剂（ＰＴＣ）在液固相体系中，转移萃取非解离型中性分子氰 化亚铜的过租。研究表明各类催化剂对氰化亚铜的萃取主要决定于各自所提供的配 位原子，其萃取转移能力可用平均络合数衡量。     

N,N-二甲基- N,N-二苯基-3,6-二氧杂辛二酰胺氯化稀土配合物的合成及表征

在非水介质中合成了六种轻稀土氯化物与配体 N,N′-二甲基 - N,N′-二苯基 - 3,6 -二氧杂辛二酰胺 (DMDD)形成的固体配合物 ,通式为 [L n(DMDD) Cl2 (H2 O) 2 ]Cl(Ln =L a～ Eu,不包括Pm) .用元素分析、摩尔电导、红外光谱、核磁共振和 TG- DTA分析对这些配合物进行了表征 .结果表明 ,在这些新配合物中 ,配体 DMDD表现为四齿配位行为     

钒刚玉光学和磁学性质的理论研究

根据完全对角化方法和一种类晶体场模型 ,统一地解释了α- Al_2 O_3:V~(3 ) 的光谱、电子顺磁共振g因子和零场分裂D值 .理论计算值与实验符合得很好 .此外 ,导出的V~(3 ) 位置的位移量 0 .0 0 86nm与浓缩红宝石中Cr3 位置的位移量 0 .0 0 6nm相接近 .     

Schiff碱H2TTAen,H2TTAdien,H2TTApn的合成和螯合性能的研究

以ＨＴＴＡ为端基与乙二胺、二乙三胺及丙二胺缩合制得Ｈ２ＴＴＡｅｎ，Ｈ２ＴＴＡｄｉｅｎ，Ｈ２ＴＴＡＰｎ３种Ｓｃｈｉｆｆ碱．它们既类似于聚酸可作多齿螯合配体，又与ｐ－二酮类似，其羰其可以异构成烯醇式，为一个二元酸．用多种近代分析测试方法对其组成和基本性质进行了表征，用ＰＨ电位法和光度法测定了酸离解常数．     

Strategies for the design of inhibitors of aldose reductase, an enzyme showing pronounced induced-fit adaptations

Aldose reductase is involved in the polyol pathway, catalyzing the reduction of glucose to sorbitol. However, due to pronounced binding site adaptations, the enzyme can operate on a broad palette of structurally diverse substrates ranging from small aliphatic and aromatic aldehydes up to steroid-type ligands. A comparative analysis of the presently accessible crystal structures of aldose reductase complexes reveals four binding-competent protein conformations. Additional relevant conformers are detected through molecular dynamics simulations. They indicate an equilibrium of several conformers which is shifted towards the binding-competent geometries upon ligand binding. Such a manifold system with several alternative binding site conformers requires some tailored concepts in virtual screening. We followed two strategies, both successfully suggesting new micromolar inhibitors. In a first attempt, we concentrated on one preferred conformer and performed a virtual screening, assuming that the binding pocket of aldose reductase adopts only this conformation. In a second approach, we followed a ligand superpositioning method. Ligands were extracted in their bound conformations from three different crystal structures, all accommodating the ligands with different active site conformations. After merging these ligands into one supermolecule, mutual alignments were computed, taking candidate ligands from a screening database. The latter strategy also retrieved several structurally new inhibitors of micromolar potency.     

Enhancing Phosphorous Recovery in a Novel Biofilter System

Developing new techniques to remove and recover phosphorous simultaneously from wastewaters is very important for sustainable utilization of phosphorous resource and prevention of eutrophication. The feasibility of phosphorus bioaccumulation in a novel continuous alternating anaerobic /aerobic biofilter and benefits of such accumulation for its further recovery as magnesium ammonia phosphate （MAP） were studied. The system was operated for seven months and employed the atomic absorption spectrophotometer （AAS） method to analyze the distribution change of magnesium and calcium with phosphate in the biofilter during that period. The benefits of utilizing the biofilter system to accumulate phosphorous ＆ magnesium and suppress calcium simultaneously to phosphorous recovery as MAP were explained with the aid of chemical equilibrium models. The improved phosphorus recovery from 42% to 82% was approved in the recovery experiments and the recovery products mainly as MAP were evidenced and characterized with scanning electron microscopy （SEM） . The study provides references for designing and operating the novel alternating anaerobic /aerobic biofilter for phosphorus bioaccumulation and recovery.     

几个有关磷的实验装置及方法的改进

本文将“无机化学实验”中几个有关磷的实验装置及方法进行了改进 ,采用封闭装置 ,避免了原实验过程污染环境的缺点 ,并可对实验产物进行鉴定与利用 ,经多次重复实验 ,效果较好 ,达到了教学目的。     

新的NS配体CYCA的合成、~(99m)Tc标记及动物分布的研究

为了探索结构与生物分布性质的关系，合成了一种新的ＮＳ配体Ｌ－半胱氨酸酞－对氯苯胺盐酸盐（ＣＹＣＡ）．以ＳｎＣｌ２为还原剂，制备了放化纯大于９３％的９９ｍＴｃＯ－ＣＹＣＡ．探讨了ｐＨ值和反应温度对９９ｍＴｃＯ—ＣＹＣＡ标记率的影响，并对其小鼠生物分布进行了研究．结果表明，９９ｍＴｃｄ－ＣＹＣＡ在脑和心肌中具有一定的浓集，在肝脏中有较高浓集，并且清除速度较慢．这些结果对于探索结构与生物分布性质的关系提供了参考．     

混配配合物的极谱研究

综述了近年来混配配合物的极谱研究概况． 讨论了混配配合物的组成及稳定常数的测定、不可逆过程的研究方法及变价离子混配配合物的极谱研究． 给出了部分混配配合物的组成和稳定常数