Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

This review discusses the state-of-the-art in molecular research on the most prominent and widely applied lantibiotic, i.e., nisin. The developments in understanding its complex biosynthesis and mode of action are highlighted. Moreover, novel applications arising from engineering either nisin itself, or from the construction of totally novel dehydrated and/or lanthionine-containing peptides with desired bioactivities are described. Several challenges still exist in understanding the immunity system and the unique multiple reactions occurring on a single substrate molecule, carried out by the dehydratase NisB and the cyclization enzyme NisC. The recent elucidation of the 3-D structure of NisC forms the exciting beginning of further 3-D-structure determinations of the other biosynthetic enzymes, transporters and immunity proteins. Advances in achieving in vitro activities of lanthionine-forming enzymes will greatly enhance our understanding of the molecular characteristics of the biosynthesis process, opening up new avenues for developing unique and novel biocatalytic processes. Received 9 April 2007; received after revision 31 August 2007; accepted 28 September 2007     

Molecular mechanisms in therapy of acid-related diseases

Inhibition of gastric acid secretion is the mainstay of the treatment of gastroesophageal reflux disease and peptic ulceration; therapies to inhibit acid are among the best-selling drugs worldwide. Highly effective agents targeting the histamine H2 receptor were first identified in the 1970s. These were followed by the development of irreversible inhibitors of the parietal cell hydrogen-potassium ATPase (the proton pump inhibitors) that inhibit acid secretion much more effectively. Reviewed here are the chemistry, biological targets and pharmacology of these drugs, with reference to their current and evolving clinical utilities. Future directions in the development of acid inhibitory drugs include modifications of current agents and the emergence of a novel class of agents, the acid pump antagonists. Received 30 May 2007; received after revision 15 August 2007; accepted 13 September 2007     

具有常余维数2k+2l不动点集的(Z2)k作用

设(Z₂)^k作用作用于光滑闭流形Mⁿ, 其不动点集具有常余维数r, J^r_n,k是具有上述性质的未定向n维上协边类［Mⁿ］构成的 集合.J^r_*,k为未定向上协边环MO_*的理想. 通过构造MO_*的一组生成元证明由所有维数大于2^k+2^l的上协边类及分解式中每个因子的维数都小于2^k的2^k+2^l维可分解上协边类构成.     

头花蓼的化学成分及药理研究进展

头花蓼是少数民族地区的常用药,主要用于肾盂肾炎、尿道感染、利尿通淋等症。对它的研究始于二十世纪八十年代,已开发了热淋清系列制剂,为了更好地开发和利用其资源,本文就头花蓼的化学成分和药理研究的进展进行了综述。     

协同虚拟维修过程中的虚拟人体维修操作控制

针对操作人员难以在有限的光学运动捕捉设备捕捉范围内自由运动的问题,开展了协同虚拟维修过程中的虚拟人体维修操作控制研究。基于光学运动捕捉设备对操作人员的下肢动作进行捕捉,根据实时识别结果控制虚拟人体进行大范围运动。针对维修操作过程中的虚拟人体手部运动控制,分析了虚拟人体的手部交互过程,提出了一种基于动态贝叶斯网络的维修操作智能辅助方法。以某液压缸协同式虚拟维修操作仿真平台为例验证了方法的有效性。该方法实现了对虚拟人体维修操作过程的有效控制,具有实时性好、交互性与感知性强等优点。     

神经营养素的生物学作用及临床应用前景

神经营养素是一类神经营养因子，目前已被用于神经萎缩、神经变性、外伤修复等疾病的治疗中．它的研究极大地推动了神经生物学和细胞生物学的发展，本文拟就神经营养素的生物学作用及临床应用前景作一简要的介绍．     

带电粒子在均匀电磁场中的运动

带电粒子在纯电场、纯磁场中运动时,其运动轨迹分别是抛物线和螺旋线.当电磁场并存时,根据相对论基本原理,带电粒子的运动并不是两种情况的简单叠加,运动轨迹与场的大小、方向有关.     

新疆雪莲的化学成分、药理作用及其临床应用

综述新疆雪莲在化学成分、药理学及临床方面的研究．通过对其多糖、黄酮、生物碱以及黄酮苷，愈创内酯、挥发油、微量元素、氨基酸等主要成分对应的药理作用的综述，介绍其在临床上作为民族药在抗炎镇痛、抗旱孕、抗衰老及抑制癌细胞增生等方面的应用前景．     

过硫酸钾在织物一浴前处理过程中分解反应动力学的研究

过硫酸钾已较为广泛的应用于织物的前处理过程中.在织物的退/煮/漂一浴前处理过程中加入少量过硫酸钾,不但可以提高处理效果,还能使纤维的强力得到有效的保护.为了更充分了解过硫酸钾在织物退/煮/漂一浴前处理过程中的分解行为,本文对过硫酸钾在该处理过程中的分解动力学进行了研究.研究结果表明,其分解反应为一级反应,并得到了其动力学参数和建立了动力学方程.结合电子顺磁共振波谱(EPR)测定结果,推定出了过硫酸钾的分解反应机理以及分解产物与浆料及纤维作用的机理.     

任务型教学对高职英语教师能力的要求

任务型教学是一种基于行动导向的、以学生为中心、以任务为驱动的教学模式.在高职英语教学中采用任务型教学具有现实意义,同时也对高职英语教师的能力提出了更高的要求.高职英语教师应具有良好的专业能力、行动能力、社会能力、反思性教学及科研能力等.