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61.
62.
Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of α-lactalbumin 总被引:1,自引:0,他引:1
Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human -lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice for 3 days. Exposure of mammary tissue to HAMLET resulted in morphological changes typical for apoptosis and in a stimulation of caspase-3 activity in alveolar epithelial cells near the HAMLET pellets but not more distant to the pellet or in contralateral glands. The effect was specific for HAMLET and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone. HAMLET also induced cell death in vitro in a mouse mammary epithelial cell line. The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissue.Received 30 January 2004; received after revision 5 March 2004; accepted 16 March 2004 相似文献
63.
64.
柳飞 《江苏技术师范学院学报》2004,10(3):85-87,94
由探索“素质”的词义人手论述“音乐素质”的内涵,针对音乐学习与教育中的某些现实问题进行探讨,强调后天的教育和学习对于提高音乐素质的意义和作用;尝试提出适合于普通高校学生实际的音乐素质评估最低标准;提出强化学生音乐素质的若干措施。 相似文献
65.
Davoli C Marconi A Serafino A Iannoni C Marcheggiano A Ravagnan G 《Cellular and molecular life sciences : CMLS》2002,59(3):527-539
Nerve growth factor (NGF) belongs by sequence homology to the neurotrophins, a family of proteins binding the same p75 receptor
and closely related members of the Trk family of receptor tyrosine kinases. Fundamental in the vertebrate nervous system,
neurotrophin signals have also been suggested as essential for relatively complex nervous systems occurring in invertebrate
species that live longer than Caenorhabditis elegans and Drosophila melanogaster. Mammalian neurotrophins have been found to influence invertebrate neuronal growth. However, there are only a few data on
the presence of molecules related to neurotrophin signalling components in invertebrates. Our studies provide evidence that
analogues of neurotrophins and neurotrophin receptors are expressed in Eisenia foetida earthworms. In particular, NGF-like and Trk-like immunoreactive proteins are both expressed in the nervous system, whereas
p75-like positivity identifies tubular structures associated with dorsal pores that are involved in the earthworm response
to mechanical irritation or stress.
Received 12 November 2001; received after revision 8 January 2002; accepted 8 January 2002 相似文献
66.
Recombinant expression of perchloric acid-soluble protein reduces cell proliferation 总被引:3,自引:0,他引:3
Kanouchi H Tachibana H Oka T Yamada K 《Cellular and molecular life sciences : CMLS》2001,58(9):1340-1343
Perchloric acid-soluble protein (PSP) may play an important role in the regulation of cellular physiological functions because
it has been highly conserved throughout evolution; however, this role has not been well elucidated. In previous reports, we
suggested that PSP regulates cell proliferation. In this study, we examined the effect of PSP expression on proliferation
of the normal rat kidney cell line NRK-52E, the rat hepatocyte cell line RLN-10, and the rat hepatoma cell line dRLh-84. Cells
transfected with pcDNA-sense-PSP (pcDNA-S-PSP) over-expressed PSP mRNA and protein, and cell proliferation of the transfected
cells was suppressed compared with that of cells transfected with pcDNA-empty (pcDNA-E). Cell viability of pcDNA-S-PSP-transfected
cells was similar to that of pcDNA-E-transfected cells. Thus, over-expression of PSP suppresses cell proliferation without
any influence on cell viability. These findings are the first to report an inhibitory activity of PSP on cell proliferation.
Received 27 April 2001; received after revision 8 June 2001; accepted 8 June 2001 相似文献
67.
68.
焦合华 《云南民族大学学报(自然科学版)》2007,16(2):95-99
首先在半预不变凸函数和(p,r)-预不变凸函数的基础上,定义了一类新的广义凸函数半(p,r)-预不变凸函数,它既是半预不变凸函数又是(p,r)-预不变凸函数的推广形式,从而是熟知的凸函数和不变凸函数的推广形式.接着,讨论了半(p,r)-预不变凸函数的一些有用性质.最后利用半(p,r)-预不变凸(凹)函数讨论了目标函数和约束函数均不可微的多目标规划问题,从而获得两个最优性条件. 相似文献
69.
正交试验优化基因工程菌(E.Coli/p WSY)产黑色素培养基的组成 总被引:5,自引:0,他引:5
宁华 《华中师范大学学报(自然科学版)》2000,34(2):220-222
用正交试验优化了基因工程菌(E.coli/p WSY)产黑色素培养基的组成。配方为:蛋白胨1%、葡萄糖0.2%、硫酸铵0.5%、磷酸氢二钾0.7%、磷酸二氢钾0.3%、氯化钠0.5%,硫酸镁0.01%,为实现微生物发酵法大规模生产黑色素提供了重要数据。 相似文献
70.
杨绍光 《南京大学学报(自然科学版)》2000,36(4):403-406
解决广义半内积空间中的Berberian技巧,并利用该技巧得到自反、严格凸的Banach空间中广义p自共轭算子的谱的性质。 相似文献