矿井通风系统评价指标向量及其应用研究

采用层次分析的方法建立了矿井通风系统评价指标体系的多层次结构框图．构造了评价指标的判断矩阵．这种方法构造的评价指标向量更为科学．具有一定的可信度．为改善矿井的通风状况提供必要的决策依据。     

阳离子管式聚合反应过程的实验研究与数学描述（Ⅰ）模型与求解

从典型的阳离子管式聚合反应过程出发，以反应度法和生成函数为工具，建立了描述此类反应过程的反应动力学。热力学及产品分子量分布的数学模型．并介绍了求解此类以偏微分方程为特征的数学模型的方法。     

鲤亚目几种名优鱼的随机扩增多态性DNA分析

采用OPA、OPC和OPM三组共60条随机引物对鲤亚目的七种名优鱼和一种杂交品种进行了随机扩增多态性DNA(m)分析,对其中35个引物的扩增条带进行了统计,计算了它们之间的遗传相似率和遗传距离,在此基础上,利用UPGMA聚类分析建立了它们之间的亲缘关系,结果与传统分类是一致的,并且将杂交品种与纯种区分开来,实验还初步筛选了7种鱼的RAPD分子标记,探讨了用R6PD技术来鉴定名优鱼应用的可行性。     

废水处理系统中功能菌株特异分子标记

用40条10碱基随机引物对油脂化工废水处理系统中分离到的降解脂肪酸和脂肪胺功能菌株FA-2。FA-3及对照菌株进行RAPD分析。筛选出长度为700bp的FA-2的特异性片段,并克隆到pMD 18-T载体上．根据测序结果,设计了1对SCAR(sequence characterized anlplfied region)引物,通过SCAR-PCR反应,获得SCAR标记,并通过对20个培养样品进行PCR扩增,验证了标记特异性．结果表明该标记可作为特异的分子标记用于污水处理系统中功能菌株FA-2的监测．     

Strategies for the design of inhibitors of aldose reductase, an enzyme showing pronounced induced-fit adaptations

Aldose reductase is involved in the polyol pathway, catalyzing the reduction of glucose to sorbitol. However, due to pronounced binding site adaptations, the enzyme can operate on a broad palette of structurally diverse substrates ranging from small aliphatic and aromatic aldehydes up to steroid-type ligands. A comparative analysis of the presently accessible crystal structures of aldose reductase complexes reveals four binding-competent protein conformations. Additional relevant conformers are detected through molecular dynamics simulations. They indicate an equilibrium of several conformers which is shifted towards the binding-competent geometries upon ligand binding. Such a manifold system with several alternative binding site conformers requires some tailored concepts in virtual screening. We followed two strategies, both successfully suggesting new micromolar inhibitors. In a first attempt, we concentrated on one preferred conformer and performed a virtual screening, assuming that the binding pocket of aldose reductase adopts only this conformation. In a second approach, we followed a ligand superpositioning method. Ligands were extracted in their bound conformations from three different crystal structures, all accommodating the ligands with different active site conformations. After merging these ligands into one supermolecule, mutual alignments were computed, taking candidate ligands from a screening database. The latter strategy also retrieved several structurally new inhibitors of micromolar potency.     

西安地区空间结构协调度综合评价

西安要参与21世纪的城市竞争,必须明确自身的空间发展战略。针对这一目标,对区域空间结构优化指标体系进行改进,增选产业空间协调度这一复合指标以及修改判断矩阵的权值。西安空间结构协调度的计算结果表明:西安空间结构正逐步趋于协调,但空间结构仍需要优化;应调整区域内城镇的区位分布,构造集中与分散相协调的空间结构体系;继续加强中心城市的辐射作用,协调各区县的产业趋同化现象,通过公路交通网络的建设,带动城市化进程和城镇密度的提高等。     

"奖优罚劣"的动态多指标灰色关联度模型研究

针对动态多指标系统决策特点 ,利用灰色关联分析方法提出了一种新的“奖优罚劣”的动态多指标决策模型。该模型不仅对指标进行初始化处理时使用了“奖优罚劣”原则 ,而且通过构造相关矩阵 ,利用特征根、特征向量的性质 ,构造最优指标体系 ,并由此确定最优指标体系中各指标的权重。通过计算决策对象与理想矩阵、负理想矩阵的关联度 ,进而得到决策对象的排序结果。模型中充分考虑了指标的成长特性 ,将其整个系统的成长特性进行比较 ,作为关联度的一部分。在经济决策的实际问题中应用该模型 ,取得较好的效果     

从分子电流观点推导"点磁荷"生磁公式

按照载流细长螺线管和细长磁铁表面分子电流具有相同的生磁作用,推导出“点磁荷“生磁的公式,并同时揭示了磁极上“磁荷“产生的磁场,实质上是细长磁铁表面分子电流的合磁场.     

The generalized inverse of singular integral operators on an open arc and its applications

After choosing weight functions suitably, we define a Banach spaceH _ω ^μ (L) and discuss the generalized inverse of singular integral operators on an open arc. Using the generalized inverse, we obtain the solutions for the following singular integral equation

道德、法律与公民意识

自改革开放以来,我国在一直大力加强法制建设的同时却忽视了道德秩序的建立。面对社会现在的“道德危机”和“法律纸面化”问题,我们必须提高道德与法律的内化力－公民意识。采取灵活多样的有效形式,推进中国法治现代化进程。