美施康定对癌症疼痛的镇痛效果

本组５４例重度癌痛晚期病人,给予口服美施康定３０～９０ｍｇ每１２ｈ一次治疗,有效率达９６３％（５２／５４）,完全缓解率达８７％（４７／５４）,主要副作用为便秘、恶心、呕吐、嗜睡等     

人非小细胞肺癌rasP^21和CD44的表达及意义

用免疫组化ＬＳＡＢ法检测４６例非小细胞肺癌ｒａｓＰ２１和ＣＤ４４的表达。结果：ｒａｓＰ２１的阳性率鳞癌为５９％,腺癌６３％;ＣＤ４４的阳性率鳞癌为４１％,腺癌６３％。统计学分析证明：不同临床分期的ｒａｓＰ２１表达强度有显著性差异（Ｐ＜００１）;有淋巴结转移与无淋巴结转移的ＣＤ４４表达程度有显著性差异（鳞癌Ｐ＜００１,腺癌Ｐ＜００２５）;ｒａｓＰ２１与ＣＤ４４表达强度两者无相关性（Ｐ＜００５）。结论：ｒａｓＰ２１的表达与预后不良有关,ＣＤ４４的表达与淋巴结转移有关。     

急性纯氧对SD大鼠损伤的研究

SD大鼠暴露于1ATA100％的急性纯氧中,对其血细胞和肺脏进行研究,以阐明急性纯氧对机体的损伤机制．结果表明：SD大鼠暴露于100％急性纯氧中不同时间,血液中红细胞的浓度（RBC）,红细胞压积（HCT）,血红蛋白浓度（HGB）,平均红细胞血红蛋白含量（MCH）,平均红细胞体积（MCV）,平均红细胞血红蛋白浓度（MCHC）,白细胞浓度（WBC）等无显著变化（P＞0．05）;但是,白细胞的分类变化显著（P＜0．05）或非常显著（P＜0.01或P＜0．001）,淋巴细胞随SD大鼠在急性纯氧中暴露的时间延长不断下降,中性粒细胞和单核细胞的总数不断升高．急性氧中暴露65小时后,20％的大鼠死亡,存活的大鼠解剖,发现肺部出现严重的炎症,肺的湿重．脂质过氧化（LPO）产物显著增加（P＜0．001）,超氧化物歧化酶（SOD）活力明显下降（P＜0．001）．     

硒水平对食管癌发病率影响的初步研究

对比研究显示食管癌高发区磁县土壤,粮食,水和正常人发硒的质量分数「分别为０．４２＊１０＾－９,０．０８＊１０＾－９,１．２４＊１０＾－９,１．１６＊１０＾－６」最高,中发区临漳县次之「分别为０．１７４＊１０＾－９,０．０４９＊１０＾－９,０．６８＊１０＾－９,０．９７＊１０＾－６」,低发区魏县最低「分别为０．１４８＊１０＾－９,０．０２６＊１０＾－９,０．２４＊１０＾－９,０．９１＊１０＾－６」,     

直肠腔内超声检查对直肠癌的诊断价值

通过腔内超声估价直肠癌浸润情况。方法;疑有直肠癌患者２１例,术前行直肠腔内超声检查。结果;经手术和是证实为直肠癌患者２１例,直肠腔内超声癌灶检出率为９０．５％,超声判断癌灶浸润深度与病理诊断符合率为９４．７％。结论：直肠腔内超声检查是判断直肠癌浸润深度,侵及肠壁周径,纵长长度的理想手段。     

羟基喜树碱诱导肺癌细胞凋亡的实验研究

通过设计不同浓度的羟基喜树碱（HCPT）处理体外培养的肺癌细胞,采用形态学与生化特征的观察及流式细胞仪进行检测.实验结果显示：羟基喜树碱（HCPT）能诱导肺癌细胞发生凋亡,且这种凋亡的作用与HCPT的浓度和作用时间有关.     

Diagnosis of prostate cancer by quantitative analysis of 3DMRSI data: A new model

Three-dimensional magnetic resonance spectroscopic imaging (3DMRSI) is helpful to identify prostate cancer (PC)from benign prostate hyperplasia (BPH) and to show the distribution of tumor infiltration. Combined with the (Cho + Cre)/Cit ratio, the z-score model can effectively discriminate prostate cancer from stromal benign prostate hyperplasia (sBPH) and detect small malignant lesions (SML).     

鸡冠花提高S180荷瘤鼠免疫功能及抑瘤作用的研究

目的研究鸡冠花对S180荷瘤鼠免疫器官的影响．方法随机将小鼠分为鸡冠花水煎液高、低剂量组，鸡冠花搅碎液高、低剂量组和对照组．每组10只，雌雄各半．用s180建立肿瘤模型，同时喂以鸡冠花制剂．结果鸡冠花液各实验组的荷瘤重均明显低于对照组(P＜0．05)．鸡冠花液各实验组胸腺和脾脏重量均明显高于对照组(P＜0．05)．以高浓度组增重明显．     

Mechanical Studies on Treatment of Malignant Tumour by Ultralow Frequency Pulsed-Gradient Magnetic Fields

Ultralow frequency (ULF) pulsed-gradient magnetic field (with the maximum intensity of 0.6-2.0 T, gradient of 10-100 T·m-1, pulse width of 20-200 ms and frequency of 0. 16-1. 34 Hz) treatment of mice can inhibit murine malignant tumour growth and can induce apoptosis of cancer cell. The apoptotic cancer cell contracted, became rounder and divorced from adjacent cells; the heterochromatin condensed and coagulated together along the inner side of the nuclear membrane; the endoplasmic reticulums expanded and fused with the cellular membrane; many apoptotic bodies which were packed by the cellular membrane appeared and were devoured by some lymphocytes and plasma. By Lorentz force the magnetic field keeps the moving ions within bounds of Larmor radius. Thus, penetrating capability of the positive and negative ions through the cell membrane was affected, even the role on the cell membrane formed.