Effects of a new cholecystokinin antagonist (GE 410) on the smooth muscle of the guinea pig ileum

Summary Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp--phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA₂=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [³H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [³H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons.     

Influence of bistramide A on the twitch tension in rat atrial heart muscle

Bistramide A, a new toxin isolated from the UrochordateLissoclinum bistratum Sluiter, was applied to rat auricular heart muscle bundles. At a stimulation frequency of 0.2 Hz, the toxin induces a dose-dependent reduction of the stimulated twitch tension force; it decreases and shortens the duration of the plateau and the slow repolarizing phase of the action potential. In the control solution, switching from a stimulation frequency of 0.2 Hz to 1 Hz decreases the force with which a positive potentiation develops either at a maintained high frequency or after switching from 1 Hz to 0.2 Hz. Bistramide A reduces both the force evoked at 1 Hz and the potentiation. The data suggest that Bistramide A blocks Na⁺ conductance; inhibits Ca⁺⁺ channels in a time-and frequency-dependent manner; reduces Na⁺–Ca⁺⁺ exchange activity; but does not modify the ability of the sarcoplasmic reticulum to be refilled although the rate of Ca⁺⁺ accumulation is decreased.     

海浪统计资料对船舶波浪弯矩设计值的影响

对船舶特别是超规范船舶进行结构的直接计算设计时,设计人员应合理选择船舶航行海域的海浪长期统计资料,根据船舶的装载工况及实际可能达到的航速,借用线性理论或非线性理论进行波浪弯矩的长期预报来确定设计值．文中就一艘大型集装箱船舶,按五个典型海域的海浪统计资料,对波浪弯矩及波浪合成弯矩作了长期预报计算,并与ＩＡＣＳ的统一纵强度要求ＵＲ－Ｓ１１的结果作比较和分析,给出了对船舶结构直接计算设计有指导意义的几点结论．     

广义块Pick型矩阵和带导数的Nevanlinna-Pick矩阵插值问题

建立了广义块Pick型矩阵和块Toeplitz矩阵之间的一种等价关系,并将其用于求解一类带导数的Nevanlinna-Pick矩阵插值问题     

Triphasic vascular effects of thiol compounds and their oxidized forms on dog coronary arteries

The vascular effects of 2-mercaptoethanol, cysteamine, L-cysteine, glutathione (GSH), cystamine and oxidized GSH (GSSG) on the isometric tension of isolated dog coronary arterial strips were examined, and these effects were compared with the triphasic response induced by dithiothreitol (DTT); a rapid and weak contraction (phase A), an intervening slow relaxation (phase B) and a slowly-developing strong contraction (phase C) which we previously reported. The responses of the arteries induced by 2-mercaptoethanol, cysteamine and L-cysteine consisted of phases A, B and C. The order of contractile potency (ED₅₀ of phase C) was DTTL-cysteine>2-mercaptoethanolcysteamine, while the order of relaxant potency (ED₅₀ of phase B) was DTT>cysteamine2-mercaptoethanol. GSSG and cystamine mainly produced relaxation, which corresponded to phase B. The phase C contraction was specific to the reduced forms of thiols, except for GSH, which produced only relaxation. The participation of endothelial cells was not essential for the contracting or relaxing effects of the thiol compounds. The phase C contraction was depressed by W-7, a calmodulin antagonist, while phase A was not. Therefore calmodulin-dependent protein kinases may participate in phase C, not in phase A.     

基于融合特征和LS-SVM的脱机手写体汉字识别

提出的脱机手写体汉字识别系统主要研究特征提取和分类识别两个模块.特征提取模块主要包括采用基于不变矩和弹性网格技术的串行特征融合方法,所得到的特征向量不仅充分反映了手写体汉字的全局和局部特征,而且具有很强的区分表达能力.分类识别模块将神经网络多类分类策略与最小二乘支持向量机相结合,所得到的分类器不仅识别率高、泛化能力强,而且有效地解决了多类分类问题.实验证明本文提出的识别系统能够取得很好的识别效果.     

板柱结构的应用研究

通过对国内外板柱结构研究成果的总结与分析,得出结论:国内外对板柱节点的静力性能研究较多,对其动力性能,尤其是板柱结构体系的动力性能研究较少;认为有必要对其进行动力性能的实验研究;并提出了钢筋混凝土板柱结构抗震设计建议方法。     

关于污染线性回归模型参数估计的注记

文[1] 、[2] 研究了简单回归模型中响应变量受到另一随机变量序列污染时，模型参数和污染系数的估计方法，但在 利用误差的不同阶矩估计给出污染系数的估计时发生了错误。我们证明了这种方法是行不通的。     

期权在公司激励中的应用

通过将相关企业的信息引入对本企业经理人的期权激励和约,建立了合理的期权激励 模型．并利用委托代理模型给出了此模型合理性的论证．     

电偶极辐射的计算方法

本文讨论了在宏观情形下,真空中分布于一个小区域内的电流,在远区所产生的电偶极辐射的计算问题.指出了文献[1]中的欠妥之处,明确了电偶极辐射的物理含义.