大跨度斜拉索输油管桥模型固有振动的实验研究

建立了大跨度斜拉索输油管桥模型实验的相似条件，并以某大跨度管桥为例，采用两种不同的边界条件，对某大跨度斜拉索输油管桥固有振动进行了模型实验，通过实验，测得到了管桥的前几阶自振频率并与有关计算结果进行了比较，比较结果验证了文中的实验方法的可靠性，提出的实验方法可以用于预报类似柔性结构体系的固有振动频率。     

游泳馆钢-木混合结构的体系选型和关键设计问题

崇明游泳馆采用钢-胶合木混合网壳结构.通过对胶合木力学特性和游泳馆结构静力的分析,计算屋面网壳结构钢和胶合木的合理应用范围.讨论了钢夹板木结构连接节点刚度对结构整体刚度的影响,并通过节点试验得到了节点的实际刚度.参考《空间网格结构技术规程》中关于网壳结构的稳定性分析和极限承载力的计算方法,考虑木材的材质缺陷和无塑性发展...     

大跨度刚构桥箱梁抗剪承载力影响参数分析

以大跨度连续刚构桥箱梁的中墩附近节段和跨中弯矩变号附近节段为研究对象,建立相关分析模型,开展包括多种剪跨比与不同配箍率、不同腹板纵向普通钢筋配筋率及不同竖向预应力的组合共54种组合分析,得出各参数对抗剪承载力的影响,分析各项因素的抗剪作用和箱梁截面抗剪机理,为桥梁抗剪设计和计算方法提供依据.     

装配式T梁桥汽车荷载效应的空间分布特征

为探讨汽车荷载作用下跨径、桥宽对装配式预应力混凝土简支T梁桥汽车荷载效应的影响,以交通部2008年T梁桥通用设计图为背景,利用实体有限元模型对比分析了25m、30m、35m三种跨径和9.0m、11.25m、13.5m、15.75m和18m五种桥宽下的竖/横向位移、竖/横向弯矩、纵向应力和扭转角,并与T梁桥实用空间解析解进行了对比分析。通过分析发现：汽车荷载作用下装配式T梁会同时出现竖向和横向挠曲变形,竖向荷载效应随桥梁宽度的增加而近似线性减小,但其横向形变效应会受桥梁跨径、宽度、布载形式等多种因素影响;当装配式T梁桥的所有T梁均使用边梁的设计活载效应时,T梁最大应力的解析结果能包络T梁的活载横向挠曲效应,但当跨径超过30m后中梁活载应力最大值可能会超过刚性横梁法的计算结果;T梁的侧向弯曲会显著增加截面中性轴附近的拉应力,且随着跨径的增大梁体侧向弯曲引起的中性轴位置处应力越大,T梁腹板外侧的分布钢筋最好能按照T梁腹板承受的横向弯矩大小设计为受力钢筋,并减小钢筋间距以更好地防止T梁腹板的竖向开裂。     

The cold case: Are rhinoviruses perfectly adapted pathogens?

Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen.     

Telomeres and meiosis in health and disease

Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis.     

From endoderm to pancreas: a multistep journey

The formation of the vertebrate pancreas is a complex process that typifies the basic steps of embryonic development. It involves the establishment of competence, specification, signaling from neighboring tissues, morphogenesis, and the elaboration of tissue-specific genetic networks. A full analysis of this multistep process will help us to understand classic principles of embryonic development. Furthermore, this will provide the blueprint for experimental programming of pancreas formation from embryonic stem cells in the context of diabetes cell-therapy. Although in the past decade many studies have contributed to a solid foundation for understanding pancreatogenesis, important gaps persist in our knowledge of early pancreas formation. This review will summarize the current understanding of the early mechanisms coming into play to pattern the "pre-pancreatic" region within the endoderm and, gradually, specify the pancreatic tissue.