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排序方式: 共有830条查询结果,搜索用时 15 毫秒
11.
为更准确地评估大跨径悬索桥的伸缩功能,及时发现病害,在现阶段基于监测数据的伸缩缝、支座状态评估通用方法的基础上,将伸缩缝和支座状态评估相结合,提出了基于监测数据的悬索桥关键约束装置状态评估方法.该方法采用小波分离法对位移数据进行波形分离,通过温度位移一致性分析并根据数据细节变化幅度分析桥梁伸缩异常阻力及其对应的病害,对... 相似文献
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刘仁国 《重庆邮电学院学报(自然科学版)》2000,12(4):46-48,82
新一代的国际海底光缆网络采用SDH的自愈环,具更高的可靠性,能更好地满足国际通信大容量业务传输的要求,本文对其网络配置和保护原理进行讨论。 相似文献
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大跨度刚构桥箱梁抗剪承载力影响参数分析 总被引:2,自引:0,他引:2
以大跨度连续刚构桥箱梁的中墩附近节段和跨中弯矩变号附近节段为研究对象,建立相关分析模型,开展包括多种剪跨比与不同配箍率、不同腹板纵向普通钢筋配筋率及不同竖向预应力的组合共54种组合分析,得出各参数对抗剪承载力的影响,分析各项因素的抗剪作用和箱梁截面抗剪机理,为桥梁抗剪设计和计算方法提供依据. 相似文献
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Dreschers S Dumitru CA Adams C Gulbins E 《Cellular and molecular life sciences : CMLS》2007,64(2):181-191
Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen. 相似文献
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Scherthan H 《Cellular and molecular life sciences : CMLS》2007,64(2):117-124
Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis. 相似文献
18.
From endoderm to pancreas: a multistep journey 总被引:2,自引:0,他引:2
Spagnoli FM 《Cellular and molecular life sciences : CMLS》2007,64(18):2378-2390
The formation of the vertebrate pancreas is a complex process that typifies the basic steps of embryonic development. It involves the establishment of competence, specification, signaling from neighboring tissues, morphogenesis, and the elaboration of tissue-specific genetic networks. A full analysis of this multistep process will help us to understand classic principles of embryonic development. Furthermore, this will provide the blueprint for experimental programming of pancreas formation from embryonic stem cells in the context of diabetes cell-therapy. Although in the past decade many studies have contributed to a solid foundation for understanding pancreatogenesis, important gaps persist in our knowledge of early pancreas formation. This review will summarize the current understanding of the early mechanisms coming into play to pattern the "pre-pancreatic" region within the endoderm and, gradually, specify the pancreatic tissue. 相似文献
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Huntington’s disease: from huntingtin function and dysfunction to therapeutic strategies 总被引:3,自引:0,他引:3
Borrell-Pagès M Zala D Humbert S Saudou F 《Cellular and molecular life sciences : CMLS》2006,63(22):2642-2660
Huntington’s disease (HD) is a neurodegenerative disorder that usually starts in middle age and is characterized by involuntary
movements (chorea), personality changes and dementia, leading to death within 10–20 years. The defective gene in HD contains
a trinucleotide CAG repeat expansion within its coding region that expresses a polyglutamine repeat in the protein huntingtin.
Together with the characteristic formation of aggregates in HD, aberrant protein interactions and several post-translational
modifications affect huntingtin during disease progression and lead to the dysfunction and death of selective neurons in the
brains of patients. The exact molecular mechanisms by which mutant huntingtin induces cell death are not completely understood
but may involve the gain of new toxic functions and the loss of the beneficial properties of huntingtin. This review focuses
on the cellular functions in which huntingtin is involved and how a better understanding of pathogenic pathways can lead to
new therapeutic approaches.
Received 24 May 2006; received after revision 5 July 2006; accepted 23 August 2006 相似文献