多通道电化学基因传感阵列用于同时检测AML相关多药耐药基因的新方法研究

本研究筛选并制备高特异性 DNA 探针,与纳米粒子标记技术相结合,设计多通道电化学基因传感阵列检测模式,建立灵敏、快速、简便、经济的AML相关多药耐药基因(MDR1和MRP)检测新方法。该方法具有较好的特异性、灵敏度和重现性,能够在1.0×10-14 ~ 1.0×10-12 M和5.0×10-14 ~ 5.0×10-12 M范围内,分别实现对AML 相关多药耐药基因序列MDR1和MRP的定量检测。该方法有望为预测肿瘤治疗效果和临床制定治疗方案提供参考依据。     

互耦效应下低复杂度的二维DOA估计算法

互耦效应会对阵列流型产生扰动并改变子阵间的旋转不变关系, 导致二维子空间类算法性能急剧下降甚至失效。传统二维波达方向(two-dimension direction of arrival, 2D-DOA)估计和互耦校正算法存在二维谱峰搜索困难、迭代寻优慢和计算量大等问题。利用均匀矩形阵列的特殊结构以及互耦系数矩阵的特点, 提出了一种互耦效应影响下能实现完全解互耦的二维旋转不变子空间算法。该算法通过合理选取3个在互耦影响下仍具备旋转不变关系的子阵列, 构建扩展的协方差矩阵, 通过一次特征分解, 即可实现2D-DOA估计和互耦抑制。从理论上证明了ESPRIT算法应用于互耦效应影响下2D-DOA估计的可行性。算法无需二维谱峰搜索和阵列互耦任何信息, 计算量得到有效降低。仿真验证了该算法能够实现稳健的2D-DOA估计, 并抑制互耦效应影响, 估计性能与无误差时的标准ESPRIT算法接近。     

Single-particle 3D reconstruction on specialized stream architecture and comparison with GPGPUs

The wide acceptance and data deluge in medical imaging processing require faster and more efficient systems to be built.Due to the advances in heterogeneous architectures recently,there has been a resurgence in the first research aimed at FPGA-based as well as GPGPU-based accelerator design.This paper quantitatively analyzes the workload,computational intensity and memory performance of a single-particle 3D reconstruction application,called EMAN,and parallelizes it on CU-DA GPGPU architectures and decouples the memory operations from the computing flow and orches-trates the thread-data mapping to reduce the overhead of off-chip memory operations.Then it exploits the trend towards FPGA-based accelerator design,which is achieved by offloading computingintensive kernels to dedicated hardware modules.Furthermore,a customized memory subsystem is also designed to facilitate the decoupling and optimization of computing dominated data access patterns.This paper evaluates the proposed accelerator design strategies by comparing it with a parallelized program on a 4-cores CPU.The CUDA version on a GTX480 shows a speedup of about 6 times.The performance of the stream architecture implemented on a Xilinx Virtex LX330 FPGA is justified by the reported speedup of 2.54 times.Meanwhile,measured in terms of power efficiency,the FPGA-based accelerator outperforms a 4-cores CPU and a GTX480 by 7.3 times and 3.4 times,respectively.     

Robust adaptive beamforming for constant modulus signal of interest

It is required in the diagonally loaded robust adaptive beamforming the automatic determination of the loading level which is practically a challenging problem.A constant modulus restoral method is herein presented to choose the diagonal loading level adaptively for the extraction of a desired sig-nal with constant modulus ( a common feature of the phase modulation signals) .By introducing the temporal smoothing technique, the proposed constant modulus restoral diagonally loaded robust adaptive beamformer provides increased capability compared with some existing robust adaptive beamformers in rejecting interferences and noise while protecting the signal-of-interest.Simulation results are included to illustrate the performance of the proposed beamformer.     

两维数字阵列雷达的数字单脉冲测角方法

研究了两维数字阵列雷达的数字单脉冲测角方法,分析了基本单脉冲测角过程中存在的问题,提出了改进的数字单脉冲测角方法。该方法在差波束形成过程中考虑了不同工作频率、不同波位的天线等效孔径的变化。针对测角误差信号的非线性特征,在根据误差信号计算目标角度时采用了多阶多项式拟合的方法,给出了数字阵列雷达中数字单脉冲测角的详细过程。计算机仿真和实测结果表明,此方法具有良好的测角性能,减少了对单脉冲测量误差曲线的存储要求,适合于工程实际应用。     

基于蚁群算法的最大似然方位估计快速算法

针对最大似然(maximum likelihood, ML)方位估计方法多维非线性搜索计算量大的问题,将连续空间蚁群算法与最大似然算法相结合,提出基于蚁群算法的最大似然 (ant colony optimization based maximum likelihood, ACOML) 估计新方法。该方法将传统蚁群算法中的信息量留存过程拓展为连续空间的信息量高斯核概率密度函数,得到最大似然方位估计的非线性全局最优解。仿真结果表明,ACOML方法保持了原最大似然方位估计方法算法的优良估计性能,而计算量只是最大似然方法的1/15。     

基于LPI的相控阵雷达辐射控制方法

相控阵雷达可通过合理配置工作参数优化其性能。针对雷达在电子对抗环境中需要具备低截获概率（low probability of intercept, LPI）的要求,从低截获原理出发,对两种辐射能量控制策略：最小功率策略和最小驻留策略的实现方法进行了理论推导。在此基础上,建立以检测概率为目标的探测性能优化模型,并给出了两种能量控制策略下的最优辐射控制方案。     

基于三线交点球麦克风阵列的远场多声源定位

设计一种三线交点球麦克风阵列,利用该阵列进行球面声压采样,实现了基于平面波分解的三维空间远场多声源定位.声源定位对比实验结果表明,采用98元的三线交点球麦克风阵列进行远场多声源定位,可以提高声源定位的精度和空间分辨率,且对环境噪声具有良好的鲁棒性.     

Color reproduction for noisy CFA data using directional cycle-spinning

This paper addresses color filter array(CFA) color reproduction problem where the aim is to utilize an image captured by the CFA to produce an image with full color information.First,conventional subband synthesis based color reproduction techniques do not consider the noise during image acquisition and assume that the CFA data are noiseless.To tackle the noisy CFA data,a novel approach is proposed by inserting a subband denoising scheme into the conventional subband synthesis framework.Second,conventional subband synthesis based techniques exploit the decimated wavelet transform that is not shift-invariant and could result in ringing artifacts in the result.To alleviate these artifacts,the directional cycle-spinning(DCS) technique is exploited.Furthermore,a new cycle-spinning pattern is proposed according to the sampling pattern of the Bayer CFA data.Extensive experiments are conducted to demonstrate that the proposed approach outperforms several approaches.     

阵列信号处理中多重信号分类算法的仿真研究

波达方向（DOA）估计是阵列信号处理研究的重要内容之一,多重信号分类（MUSIC）算法是一种经典有效的DOA方法。概述了阵列信号处理研究的主要内容,详细介绍了多重信号分类算法的原理,并用MATLAB进行仿真实现该算法,研究了MUSIC算法的性能。